A5008801653- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Pancreatic and Hepatic Oncology Research
- Childhood Cancer Survivors' Quality of Life
- Global Cancer Incidence and Screening
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Intraperitoneal and Appendiceal Malignancies
- Pancreatitis Pathology and Treatment
- Economic and Financial Impacts of Cancer
- Family Support in Illness
- CAR-T cell therapy research
- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Patient-Provider Communication in Healthcare
- Appendicitis Diagnosis and Management
- Cancer Treatment and Pharmacology
- Clinical practice guidelines implementation
- Cancer Immunotherapy and Biomarkers
- Advances in Oncology and Radiotherapy
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Multiple Myeloma Research and Treatments
McMaster University
2016-2025
University of Pennsylvania
2004-2025
UPMC Hillman Cancer Center
2023-2025
Children's Hospital of Philadelphia
2024-2025
Penn Center for AIDS Research
2024-2025
University of Pennsylvania Health System
2005-2025
University of Cincinnati Medical Center
2015-2024
Cancer Research Institute
2023-2024
Juravinski Cancer Centre
2014-2024
University of Cincinnati
2015-2024
Purpose For patients with relapsed or refractory aggressive lymphoma, we hypothesized that gemcitabine-based therapy before autologous stem-cell transplantation (ASCT) is as effective and less toxic than standard treatment. Patients Methods We randomly assigned 619 relapsed/refractory lymphoma to treatment gemcitabine, dexamethasone, cisplatin (GDP) cytarabine, (DHAP). B-cell also received rituximab. Responding proceeded collection ASCT. Coprimary end points were response rate after two...
Purpose Ontario's cancer system is unique because it has implemented two standardized assessment tools population-wide to improve care: the Edmonton Symptom Assessment System (ESAS) measures severity of nine symptoms (scale 0 10; 10 indicates worst) and Palliative Performance Scale (PPS) performance status 100; death). This article describes trajectory ESAS PPS scores 6 months before death. Patients Methods Observational cohort study decedents between 2007 2009. Decedents required ≥1 or in...
An Institute of Medicine report recommends that patients with cancer receive a survivorship care plan (SCP). The trial objective was to determine if an SCP for breast survivors improves patient-reported outcomes.Women early-stage who completed primary treatment at least 3 months previously were eligible. Consenting allocated within two strata: less than 24 and ≥ since diagnosis. All transferred their own physician (PCP) follow-up. In addition discharge visit, the intervention group received...
<b>Objective</b> To determine the pooled effect of exposure to one 11 specialist palliative care teams providing services in patients’ homes. <b>Design</b> Pooled analysis a retrospective cohort study. <b>Setting</b> Ontario, Canada. <b>Participants</b> 3109 patients who received from 2009-11 (exposed) matched by propensity score usual (unexposed). <b>Intervention</b> The studied served different geographies and varied team composition size but had same core members role: group physicians,...
Asthma in children and young adults is strongly associated with immediate hypersensitivity to indoor allergens, notably those derived from the house dust mite. In addition, outdoor air pollution considered aggravate existing asthma. We investigated prevalence of asthma pattern allergen sensitization a mite-free environment low levels pollution. A total 567 aged between 12 14 attending Los Alamos Middle School, NM (altitude 7,200 feet) were screened using respiratory questionnaire; 120 (53...
Abstract The Sunbelt Melanoma Trial is an ongoing multicenter prospective randomized trial that involves 79 centers and over 3600 patients from across the United States Canada. This one of first large studies to incorporate molecular staging using reverse transcriptase polymerase chain reaction (RT‐PCR). While results related primary endpoints study are not yet available, several analyses have shed light on many aspects sentinel lymph node (SLN) biopsy melanoma prognostic factors. In...
To determine in a randomized prospective multi-institutional trial whether the addition of tumor necrosis factor alpha (TNF-alpha) to melphalan-based hyperthermic isolated limb perfusion (HILP) treatment would improve complete response rate for locally advanced extremity melanoma.Patients with melanoma were randomly assigned receive melphalan or plus TNF-alpha during standard HILP. Patient randomization was stratified according disease/treatment status and regional nodal disease status.The...
Abstract BACKGROUND. For ambulatory cancer patients, Ontario has standardized symptom and performance status assessment population‐wide, using the Edmonton Symptom Assessment System (ESAS) Palliative Performance Scale (PPS). In a broad cross‐section of outpatients, authors describe ESAS PPS scores their relation to patient characteristics. METHODS. This is descriptive study administrative healthcare data. RESULTS. The cohort included 45,118 23,802 patients' first PPS, respectively. Fatigue...
The initial biopsy specimens from 50 patients with high-grade invasive transitional cell carcinoma of the urinary bladder were evaluated for depth invasion. Stages assigned according to following system: T1A, invasion connective tissue superficial level muscularis mucosae; T1B, T1C, through mucosae but propria; and B, into propria. Follow-up Yale Tumor Registry at a median time 4.6 years showed that tumors levels T1A T1B had 75% 5-year survival, apparently propria (level T1C) an 11% which...
To better understand the factors associated with well-established gender difference in survival for patients melanoma.Gender is an important factor cutaneous melanoma. Male have a worse outcome when compared females. The reasons this are poorly understood.This prospective multi-institutional study included aged 18 to 70 years melanomas > or =1.0 mm Breslow thickness. Wide excision and sentinel lymph node (SLN) biopsy was performed all patients. Clinicopathologic factors, including gender,...
To evaluate the effect of balloon size and inflation pressure on acute subsequent outcome following angioplasty (BA), 70 New Zealand White rabbits with bilateral femoral atherosclerosis were assigned to four groups: group 1, oversized balloon, low (n = 35 vessels; size, 3.0 mm/inflation pressure, 5 atm); 2, high 36; mm/10 3, appropriate 17; 2.5 mm/5 4, 19; atm). Angiograms obtained before, 10 minutes after, 28 days after BA read by two blinded observers using electronic calipers. The in vivo...
Total pancreatectomy and islet cell autotransplantation (TPIAT) has been increasingly utilized for the management of chronic pancreatitis (CP) with early success. However, long-term durability this operation remains unclear.All patients undergoing TPIAT treatment CP 5-year or greater follow-up were identified inclusion in single-center observational study. End points included narcotic requirements, glycemic control, function, quality life (QOL), survival.Between 2000 2013, 166 underwent...
Background Virtual follow-up (VFU) has the potential to enhance cancer survivorship care. However, a greater understanding is needed of how VFU can be optimized. Objective This study aims examine how, for whom, and in what contexts works Methods We conducted realist evaluation among patients with breast prostate at an urban center during COVID-19 pandemic. Realist evaluations underlying causal processes intervention (mechanisms) specific circumstances (contexts) interact produce results...
To evaluate the prognostic significance of molecular staging using reverse transcriptase polymerase chain reaction (RT-PCR) in detecting occult melanoma cells sentinel lymph nodes (SLNs) and circulating bloodstream.In this multicenter study, eligibility criteria included patient age 18 to 71 years, invasive > or = 1.0 mm Breslow thickness, no clinical evidence metastasis. SLN biopsy wide excision primary tumor were performed. SLNs examined by serial-section histopathology S-100...