A5051555467- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- AI in cancer detection
- Autoimmune Bullous Skin Diseases
- Renal Transplantation Outcomes and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Complement system in diseases
- Machine Learning in Healthcare
- SARS-CoV-2 and COVID-19 Research
- Renal and related cancers
- Colorectal Cancer Screening and Detection
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- COVID-19 and healthcare impacts
- T-cell and B-cell Immunology
- Fibroblast Growth Factor Research
- Renal and Vascular Pathologies
Arkana Laboratories
2020-2024
The Ohio State University
2019-2024
The Ohio State University Wexner Medical Center
2018-2021
Cerebral Palsy Research Network
2020
Research Network (United States)
2020
University of Toronto
2010-2019
University Health Network
2010-2018
SUNY Upstate Medical University
2018
Kidney Research UK
2018
Ontario Institute for Cancer Research
2012-2018
The application of deep learning for automated segmentation (delineation boundaries) histologic primitives (structures) from whole slide images can facilitate the establishment novel protocols kidney biopsy assessment. Here, we developed and validated networks structures on biopsies nephrectomies. For development, examined 125 Minimal Change Disease collected across 29 NEPTUNE enrolling centers along with 459 stained Hematoxylin & Eosin (125), Periodic Acid Schiff Silver (102), Trichrome...
Kidney failure is common in patients with Coronavirus Disease-19 (COVID-19), resulting increased morbidity and mortality. In an international collaboration, 284 kidney biopsies were evaluated to improve understanding of disease COVID-19. Diagnoses compared five years 63,575 native prior the pandemic 13,955 allograft identify diseases that have Genotyping for APOL1 G1 G2 alleles was performed 107 African American Hispanic patients. Immunohistochemistry SARS-CoV-2 utilized assess direct viral...
Immune responses to vaccination are a known trigger for new onset of glomerular disease or flare in susceptible individuals. Mass immunization against SARS-CoV-2 the COVID-19 pandemic provides unique opportunity study vaccination-associated autoimmune kidney diseases. In recent literature, there several patient reports demonstrating temporal association and
Abstract Aim Allograft rejection is a serious concern in heart transplant medicine. Though endomyocardial biopsy with histological grading the diagnostic standard for rejection, poor inter-pathologist agreement creates significant clinical uncertainty. The aim of this investigation to demonstrate that cellular grades generated via computational analysis are on-par those provided by expert pathologists Methods and results study cohort consisted 2472 slides originating from three major US...
Novel anticancer therapies include anti-programmed cell death protein-1 (PD-1) and ligand-1 (PD-L1) drugs. These novel medications have side effects in different organs, including the kidney. The most common adverse effect kidney is acute interstitial nephritis (AIN). No diagnostic criteria are available to distinguish AIN associated with anti-PD-1 therapy from other AINs.Kidney biopsy specimens patients on were stained antibodies PD-1 PD-L1. Herein we report morphologic immunohistochemical...
Inconsistencies in the preparation of histology slides and whole-slide images (WSIs) may lead to challenges with subsequent image analysis machine learning approaches for interrogating WSI. These variabilities are especially pronounced multicenter cohorts, where batch effects (i.e. systematic technical artifacts unrelated biological variability) introduce biases algorithms. To date, manual quality control (QC) has been de facto standard dataset curation, but remains highly subjective is too...
Abstract Background Primary immunoglobulin A nephropathy (IgAN) is characterized by IgA1-dominant or codominant glomerular deposits, postulated to be galactose deficient (Gd). However, IgA deposition can also occur in nonrenal diseases such as liver cirrhosis, psoriasis and inflammatory bowel disease (‘secondary IgAN’) an incidental finding biopsies with other pathologies. glomerulonephritis resembling IgAN develop patients bacterial, mainly staphylococcal infections [staphylococcal...
Abstract Aims Immune checkpoint inhibitors (ICIs) have revolutionised the treatment of advanced malignancies by boosting immune‐mediated destruction neoplastic cells, but are associated with side effects stemming from generalised immune system activation against normal tissues. Checkpoint ligand expression in non‐tumoral cells tissues affected immune‐related adverse has been described ICI‐associated hypophysitis, myocarditis, and acute interstitial nephritis. We aimed to investigate tissue...
Fibroblast growth factor (FGF) receptor 2 (FGFR2) has been identified in genome-wide association studies to be associated with increased breast cancer risk; however, its mechanism of action remains unclear. Here we show that the two major FGFR2 alternatively spliced isoforms, FGFR2-IIIb and FGFR2-IIIc, interact IκB kinase β downstream target, NF-κB. inhibits nuclear RelA/p65 NF-κB translocation activity reduces expression dependent transcripts, including interleukin-6. These interactions...
Since the discovery of causative agent for novel severe acute respiratory syndrome (SARS)–like pneumonia pandemic that started in China 2019 (1,2), a coronavirus named SARS 2 (SARS-CoV-2), electron microscopy images have populated medical literature (2) and media outlets alike displaying characteristic 60–140 nm round particles surrounded by "corona" 9–12 distinctive spikes (2). Although many these were obtained after "in vitro" infection cultured cells with SARS-CoV-2 are thus likely true...
CCR5 KO kidney transplant (KTx) recipients are extraordinarily high alloantibody producers and develop pathology that mimics human antibody-mediated rejection (AMR). C57BL/6 mice (H-2b) were transplanted with A/J kidneys (H-2a); select cohorts received adoptive cell therapy (ACT) alloprimed CXCR5+CD8+ T cells (or control cells) on day 5 after KTx. ACT efficacy was evaluated by measuring posttransplant alloantibody, pathology, allograft survival. Recipients assessed for the quantity of...
COVID-19 associated nephropathy (COVAN) is the most common cause of acute kidney injury (AKI) in Black patients with SARS-CoV-2 infection undergoing biopsy. It presents AKI and proteinuria, often nephrotic-range. The histopathology COVAN collapsing glomerulopathy (CG), severe form focal segmental glomerulosclerosis.1 pattern CG also seen setting other infections (including human immunodeficiency virus, T-cell lymphotrophic virus-1, filariasis, leishmaniasis, parvovirus B19, cytomegalovirus,...
Differential diagnosis of primary IgA nephropathy (IgAN) and IgA-dominant infection-related glomerulonephritis, particularly Staphylococcus infection−associated glomerulonephritis (SAGN), on a kidney biopsy sample can be challenging because similar morphologic findings by light microscopy, immunofluorescence, electron microscopy.1Spector D.A. Millan J. Zauber N. et al.Glomerulonephritis Staphylococcal aureus infections.Clin Nephrol. 1980; 14: 256-261PubMed Google Scholar, 2Yamashita Y....