A5105189940- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Neurological Complications and Syndromes
- Hematopoietic Stem Cell Transplantation
- Herpesvirus Infections and Treatments
- Renal Diseases and Glomerulopathies
- Pharmacological Effects and Toxicity Studies
- Healthcare Policy and Management
- Adolescent and Pediatric Healthcare
- Viral-associated cancers and disorders
- Parathyroid Disorders and Treatments
- Healthcare professionals’ stress and burnout
- Muscle and Compartmental Disorders
- Chronic Kidney Disease and Diabetes
- Bone health and treatments
- Complement system in diseases
- Cell death mechanisms and regulation
- Neuroendocrine Tumor Research Advances
- Nuclear Receptors and Signaling
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adrenal and Paraganglionic Tumors
Midwest Therapeutic Endoscopy
2023
Singer (United States)
2014
Barnes-Jewish Hospital
1998-2011
St Peter's Hospital
2011
Washington University in St. Louis
1995-2000
American College of Surgeons
2000
Mallinckrodt (United States)
1998
University of Missouri–St. Louis
1998
Harvard University
1994
Brigham and Women's Hospital
1994
Abstract. Many complications after renal transplantation can be prevented if they are detected early. Guidelines have been developed for the prevention of diseases in general population, but there no comprehensive guidelines and transplantation. Therefore, Clinical Practice Committee American Society Transplantation these to help physicians other health care workers provide optimal transplant recipients. The also intended indirectly patients receive access that need ensure long-term...
Kidney failure is common in patients with Coronavirus Disease-19 (COVID-19), resulting increased morbidity and mortality. In an international collaboration, 284 kidney biopsies were evaluated to improve understanding of disease COVID-19. Diagnoses compared five years 63,575 native prior the pandemic 13,955 allograft identify diseases that have Genotyping for APOL1 G1 G2 alleles was performed 107 African American Hispanic patients. Immunohistochemistry SARS-CoV-2 utilized assess direct viral...
Background. The aim of this study was to compare the efficacy and safety Thymoglobulin (a rabbit-derived polyclonal antibody) Atgam horse-derived for induction in adult renal transplant recipients. Methods. Transplant recipients (n=72) were randomized 2:1 a double-blinded fashion receive (n=48) at 1.5 mg/kg intravenously or (n=24) 15 intravenously, intraoperatively, then daily least 6 days. Recipients observed 1 year follow-up. Results. By after transplantation, 4% Thymoglobulin-treated...
Background: Medical students experience a high burden of stress and suffer elevated rates depression, burnout, suicide compared to the general population, yet there is no consensus on how address student wellness. Purposes: The purpose this study was determine whether an abridged mindfulness based reduction (MBSR) intervention can improve measures wellness in randomized sample 1st-year medical students. Methods: Fifty-eight participants were control or 8-week MBSR then invited participate...
Background. The aim of this study was to demonstrate that 3-days induction immunosuppression with thymoglobulin as effective and safe a 7-day course reduced initial hospitalization after transplantation. Methods. This prospective, nonrandomized trial 40 consecutive patients receiving for 3 days followed 1 year. An historical group 48 received 7 served controls. Results. At year, acute rejection (5 vs. 4%), graft survival (95vs. 98%) patient were similar; composite end point freedom from...
Cytomegalovirus (CMV) DNA levels were measured by quantitative-competitive polymerase chain reaction (PCR) in weekly leukocyte samples from 50 renal transplant recipients, including 23 with symptomatic and 27 asymptomatic CMV infection. Peak week 4 higher subjects (P = .07 .02, respectively). In a logistic regression model, the logarithm of level independently predicted infection (odds ratio, 1.78 for 1 log10 increase; 95% confidence interval, 1.14–2.78; P .01). All whose exceeded 1000...
Background. Preliminary results from clinical trials suggest that 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitors may help prevent acute renal allograft rejection. However, the mechanism for this putative effect of inhibitors, and whether it is independent lipid-lowering per SE are unknown. Methods. Immediately after transplantation we randomly allocated (proportioned 2:1:2) patients to: 1) simvastatin (10 mg/day, n=53), 2) placebo plus gemfibrozil (dose adjusted function, n=36),...
The use of expanded criteria donors (ECDs) in cadaveric renal transplantation is increasing the US. We assess economic impact ECDs to Medicare end stage disease program.The United Nations for Organ Sharing transplant registry was merged claims data 42,868 transplants performed between 1991-1996 using USRDS identifiers. Only recipients whom primary payer were considered, leaving 34,534 transplants. An ECD defined as (1) age < or =5 > =55 years, (2) nonheart-beating donors, donor history (3)...
Background. We found previously that the clinical advantages of living donor (LD) renal transplantation lead to financial cost savings compared either cadaveric donation (CAD) or dialysis. Here, we analyze sources LD versus CAD kidney transplantation. Methods. used United States Renal Data System data merge Network for Organ Sharing registry information with Medicare claims 1991–1996. Information was available 42,868 and 13,754 transplants. More than 5 million payment records were analyzed....
The potential economic effects of the allocation cadaveric kidneys on basis tissue-matching criteria are controversial. We analyzed costs associated with transplantation various numbers HLA mismatches and examined benefits a local, as compared national, system designed to minimize between donor recipient in first renal transplantations.
The purpose of this study was to compare the prevalence human herpesvirus (HHV)—7 and cytomegalovirus (CMV) viremia effects oral intravenous (iv) ganciclovir in renal transplant recipients at risk for CMV. Stored lysates from peripheral blood leukocytes 92 patients, who had been previously analyzed CMV by polymerase chain reaction (PCR) 12 weeks after transplantation, were HHV-7 viremia. Baseline peak prevalences 22% 54%, respectively (P < .0001). Eightytwo (89%) patients least 1 positive...
We conducted a national survey to assess the opinions and experiences of transplant center staff related processes care graduation.
Acute rejection of renal allografts is mediated by infiltrating alloreactive T cells. The goals this study were to correlate cell proliferation with and determine whether in the absence would predict future episodes. Toward this, kidney biopsies (n=100) cultured presence interleukin-2. Cultures examined at 4, 24, 48 hr for proliferation. A strong correlation was observed between any time point rejection. There not a significant no occurrence episode within 2 months. However, after 4 better...
<b><i>Introduction:</i></b> Fibrillary glomerulonephritis (FGN) is a rare glomerular disease with poor prognosis, characterized by deposition of randomly arranged fibrillar material measuring 10–30 nm in diameter. This diagnosis confirmed DNAJB9 immunohistochemistry as well ultrastructural examination. Ultrastructurally, the fibrillary seen this entity may be confused diabetic fibrillosis occurring nephropathy. <b><i>Case Presentation:</i></b>...
Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively merits of an allocation cadaveric kidneys based on broader classes HLA antigens, called cross-reactive groups (CREG). The objectives consider patient outcomes, but not potential economic impact CREG-based allocation. This predicts local 3-year Medicare payments and graft survival.The UNOS renal transplant registry was merged claims data 1991-1997 by States Renal Data System. Average accumulated...