A5006746196- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Autoimmune Bullous Skin Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- Renal cell carcinoma treatment
- Renal and related cancers
- Pancreatitis Pathology and Treatment
- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Metabolism and Genetic Disorders
- Platelet Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Pediatric Urology and Nephrology Studies
- Retinal and Optic Conditions
- Chronic Lymphocytic Leukemia Research
- Renal and Vascular Pathologies
- Tuberous Sclerosis Complex Research
- Explainable Artificial Intelligence (XAI)
- IgG4-Related and Inflammatory Diseases
- Functional Brain Connectivity Studies
- Abdominal vascular conditions and treatments
- Mental Health Treatment and Access
- Acute Lymphoblastic Leukemia research
Washington University in St. Louis
2022-2024
Arkana Laboratories
2012-2023
Augusta University
2009
Hospital Haroldo Juaçaba
2008
University of Maryland, Baltimore
2001-2003
University of Maryland Medical Center
2001
Johns Hopkins Hospital
2001
Universidade Federal do Ceará
2000
Kidney failure is common in patients with Coronavirus Disease-19 (COVID-19), resulting increased morbidity and mortality. In an international collaboration, 284 kidney biopsies were evaluated to improve understanding of disease COVID-19. Diagnoses compared five years 63,575 native prior the pandemic 13,955 allograft identify diseases that have Genotyping for APOL1 G1 G2 alleles was performed 107 African American Hispanic patients. Immunohistochemistry SARS-CoV-2 utilized assess direct viral...
The diagnosis of membranoproliferative glomerulonephritis (MPGN) has recently undergone change from an electron microscopy-based classification scheme to one based largely on immunofluorescence findings. This is due the recognition that many these cases are driven by abnormalities alternative complement cascade, resulting in concept C3 glomerulopathy. Here we reviewed our case files identify those with MPGN pattern show false negative staining for monoclonal immunoglobulins routine...
Immune responses to vaccination are a known trigger for new onset of glomerular disease or flare in susceptible individuals. Mass immunization against SARS-CoV-2 the COVID-19 pandemic provides unique opportunity study vaccination-associated autoimmune kidney diseases. In recent literature, there several patient reports demonstrating temporal association and
Nephritis is a common manifestation of IgA vasculitis and morphologically indistinguishable from nephropathy. While MEST-C scores are predictive kidney outcomes in nephropathy, their value nephritis has not been investigated large multiethnic cohorts.
Export Primary renal tubulointerstitial disease resulting from proximal tubule antigen–specific antibodies and immune complex formation has not been well characterized in humans. We report a cohort of patients with distinct, underappreciated kidney by antibrush border failure (ABBA disease). identified ten ABBA who had combination damage, IgG-positive deposits the tubular basement membrane, circulating reactive normal human brush border. All but one also segmental glomerular on biopsy...
Kidney tubules use fatty acid oxidation (FAO) to support their high energetic requirements. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO, and it necessary transport long-chain acids into mitochondria. To define role of tubular CPT1A in aging injury, we generated mice with tubule-specific deletion Cpt1a (Cpt1aCKO mice), were either aged 2 years or injured by aristolochic unilateral ureteral obstruction. Surprisingly, Cpt1aCKO had no significant differences...
Androgen receptor (AR) signaling regulates the development and homeostasis of male reproductive organs, including prostate. Deregulation AR coregulators, expression, or activity is involved in initiation prostate cancer contributes to transition disease hormone-refractory stage. The ubiquitous betaArrestin proteins are now recognized as bona fide adapters signal transducers with target effectors found both cytosol nucleus. Here, we provide evidence that betaArrestin2 forms a complex acts an...
The effects of nephropathy risk variants in the apolipoprotein L1 gene (APOL1) on renal histopathology African Americans with arterionephrosclerosis or putative 'hypertension-associated' are unknown. APOL1 genotype-phenotype correlations were performed a blinded manner from biopsies 196 self-reported kidney biopsy at large national nephropathology practice. Subjects had chronic disease without nephrotic syndrome. A discovery analysis compared histopathologic changes glomerular and...
Intravascular hemolysis is relatively rare but can lead to acute kidney injury (AKI), from increased destruction of erythrocytes and release free hemoglobin. Since hemoglobinuria are known causes we sought define clinicopathologic findings outcomes patients with hemolysis-associated hemoglobin cast nephropathy through a retrospective analysis 27 cases. The mean patient age was 47 years (range 19-79) the female-to-male ratio 1.3:1. All presented AKI serum creatinine 8.0 2.9-17.0) mg/dL....
An increased density of neurons in the white matter neocortex has been found schizophrenia, and original reports suggested this abnormality was restricted to a subgroup patients. In study inferior parietal cortex, we that deficit schizophrenia subjects, but not nondeficit had an ICWMs. We extended finding by comparing microtubule-associated protein 2-immunoreactive ICWMs (N = 3), 4), control 5) using postmortem tissue from dorsolateral prefrontal cortex (Brodmann area 46). The group differed...
Xp11.2 translocation renal cell carcinomas (TRCCs) are a rare family of tumors newly recognized by the World Health Organization (WHO) in 2004. These result fusion partner genes to TFE3 gene located on Xp11.2. They most common pediatric population, but have been recently implicated adult carcinoma (RCC) presenting at an early age. TFE3-mediated direct transcriptional upregulation Met tyrosine kinase receptor triggers dramatic activation downstream signaling pathways including protein B...
Clear cell stromal tumour of the lung (CCST-L) is a rare, recently recognised neoplasm which has been found to express TFE3 and harbour YAP1::TFE3 fusions. Initial data suggested benign process; however, single reported case gave rise distant metastases. We sought describe clinicopathological molecular features additional cases CCST-L.Pathology archives were searched for CCST-L or tumours with Clinical noted. Available slides, including immunohistochemical studies, re-reviewed diagnosis...
Background. Acute transplant glomerulitis is a unique lesion in renal allografts, the prognostic significance of which controversial. We conducted this retrospective cohort study to examine independent moderate-to-severe acute rejection. Methods. Renal allograft survival for patients with rejection were studied, comparing one group significant (G, n=28) those no (NG, n=35). Clinical, biopsy, and demographic data graft compared, association G failure was examined. Results. In versus NG group,...
Gene expression profiling (GEP) from formalin-fixed paraffin-embedded (FFPE) renal allograft biopsies is a promising approach for feasibly providing molecular diagnosis of rejection. However, large-scale studies evaluating the performance models using NanoString platform data to define archetypes rejection are lacking. We tested diverse retrospective cohort over 1400 FFPE biopsy specimens, rescored according Banff 2019 criteria and representing ten 11 UNOS regions, Human Organ Transplant...
Messias, Erick M.D.; Sampaio, Jose Jackson M.D., Ph.D.; Nidia Cordeiro Kirkpatrick, Brian M.D. Author Information