A5025399289- Systemic Lupus Erythematosus Research
- Renin-Angiotensin System Studies
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Rheumatoid Arthritis Research and Therapies
- interferon and immune responses
- Genetic Associations and Epidemiology
- Amyotrophic Lateral Sclerosis Research
- Hepatitis C virus research
- Renal Diseases and Glomerulopathies
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Fractal and DNA sequence analysis
- Monoclonal and Polyclonal Antibodies Research
- Chronic Kidney Disease and Diabetes
- Paraoxonase enzyme and polymorphisms
- Spine and Intervertebral Disc Pathology
- Bone and Joint Diseases
- Genomics and Phylogenetic Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Machine Learning in Bioinformatics
- Spondyloarthritis Studies and Treatments
- RNA Research and Splicing
- Autoimmune Bullous Skin Diseases
University of Arkansas for Medical Sciences
2011-2022
Aga Khan University
2003-2022
Mashhad University of Medical Sciences
2018
Baqai Institute of Diabetology and Endocrinology
2018
Arkana Laboratories
2013-2017
Salford Royal NHS Foundation Trust
2014-2016
Salford Royal Hospital
2016
University of Arkansas at Little Rock
2014
Northwestern University
2006-2009
Umeå University
2009
Twenty percent of the familial form amyotrophic lateral sclerosis (ALS) is caused by mutations in Cu, Zn-superoxide dismutase gene (SOD1) through gain a toxic function. The nature this function mutant SOD1 has remained largely unknown. Here we show that WT not only hastens onset ALS phenotype but can also convert an unaffected to transgenic mouse models. Further analyses single- and double-transgenic mice revealed conversion from soluble aggregated detergent-insoluble was associated with...
Collapsing glomerulopathy is a devastating renal disease that primarily affects African Americans and associates with numerous etiologies, such as HIV autoimmune disease. The presence of APOL1 risk alleles HIV-associated collapsing glomerulopathy, but it unknown whether these also associate systemic lupus erythematosus (SLE) -associated glomerulopathy. Here, re-examination 546 biopsies from African-American patients SLE identified 26 cases which we genotyped for using DNA extracted archived...
Abstract The effect of an aqueous extract Nigella sativa seeds was studied on candidiasis in mice. An intravenous inoculum Candida albicans produced colonies the organism liver, spleen and kidneys. Treatment mice with plant (6.6 mL/kg equivalent to 5 mg estimated protein, once daily for 3 days) 24 h after inoculation caused a considerable inhibitory growth all organs studied. A 5‐fold decrease kidneys, 8‐fold liver 11‐fold observed groups animals post‐treated extract. Histopathological...
Paraoxonases (PONs) are involved in the detoxification of organophosphate pesticides and chemical nerve agents. Due to a reported possible twofold increased risk ALS Gulf War veterans associations PON1 polymorphisms with neurologic symptom complex syndrome, authors investigated association between sporadic (SALS) PON gene cluster variants large North American Caucasian family-based case-control cohort (N = 1,891).Clinically definite probable was diagnosed according revised El Escorial...
The alanine to valine mutation at codon 4 (A4V) of SOD1 causes a rapidly progressive dominant form amyotrophic lateral sclerosis (ALS) with exclusively lower motor neuron disease and is responsible for 50% mutations associated familial ALS in North America. This rare Europe. authors investigated the origin (geographic time) A4V mutation.Several cohorts were genotyped: American patients confirmed (n = 54), Swedish 3) Italian 6) patients, non-A4V 66) sporadic 96), healthy white African 17),...
The effects of nephropathy risk variants in the apolipoprotein L1 gene (APOL1) on renal histopathology African Americans with arterionephrosclerosis or putative 'hypertension-associated' are unknown. APOL1 genotype-phenotype correlations were performed a blinded manner from biopsies 196 self-reported kidney biopsy at large national nephropathology practice. Subjects had chronic disease without nephrotic syndrome. A discovery analysis compared histopathologic changes glomerular and...
<title>Abstract</title> <italic>Objective:</italic> Axial spondyloarthritis (AxSpA) and Behçet's disease (BD) have clinical HLA locus overlap been grouped under MHC-I-opathy. This study aimed to identify overlapping loci between AxSpA BD help elucidate MHC-I-opathy pathogenesis. <italic>Methods:</italic> Association clustering methods, such as OASIS, reduce the multiple-testing burden are more powerful than single variant analysis for identifying modest genetic effects. Two large publically...
The in vitro effect of aqueous extract Nigella sativa seeds on nitric oxide (NO) production by murine macrophages was studied. Murine peritoneal were pre-incubated with the and then activated Escherichia coli lipopolysaccharride. NO measured after 24 hours spectrophotometry. plant caused a dose-dependent decrease production. Dialyzed preparation did not affect However, boiled fraction resulted inhibition apparently comparable to that whole extract. These results indicate N. exhibits an...
The authors tested the association of three vascular endothelial growth factor (VEGF) promoter polymorphisms with sporadic ALS (SALS) to verify results a previous study and investigate their modifier effects on subphenotypes SALS in large family-based case-control cohort North American white subjects (N = 1,603). They did not find any VEGF or its subphenotypes, suggesting that they do have direct causal role ALS.
Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads damage in dopaminergic and serotonergic axons of selected brain regions. Previous studies showed cinnamaldehyde improved memory impairment animals. In present study, we aimed elucidate effects on methamphetamine-induced rats.Male Wistar rats received (10 mg/kg, intraperitoneally) for 7 days. Thirty minutes before each injection, animals were given (20,...
Polymorphisms of paraoxonase gene (PON) cluster have been investigated in numerous studies for their association with myocardial infarction (MI) but the results conflicting. Epistasis and gene-environment interactions at this locus could possibly modulate susceptibility toward MI account discrepancies. We carried out a case-control study (211 patients 370 control subjects) to test PON polymorphisms MI, each other smoking. Genotyping was performed by PCR-restriction fragment length...
Riluzole is the only FDA approved drug for treatment of amyotrophic lateral sclerosis. assumed to be mainly metabolized by liver cytochrome CYP1A2 and extra‐hepatic CYP1A1. CYP1A1 genetic polymorphisms are known, but their relationship riluzole metabolism in ALS patients has not been investigated. The aim this study was determine whether genes associated with metabolic profiles. Thirty‐two a diagnosis probable or definite who were on riluzole, participated study. Trough peak plasma levels...