A5074732072- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Urinary Tract Infections Management
- Metabolism and Genetic Disorders
- Ion Transport and Channel Regulation
- Neonatal Health and Biochemistry
- Electrolyte and hormonal disorders
- Complement system in diseases
- Biomedical Research and Pathophysiology
- Celiac Disease Research and Management
- Dialysis and Renal Disease Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Kidney Stones and Urolithiasis Treatments
- Chronic Kidney Disease and Diabetes
- Nitric Oxide and Endothelin Effects
- Platelet Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ureteral procedures and complications
- Blood groups and transfusion
- Renal Transplantation Outcomes and Treatments
- Ion channel regulation and function
- Erythropoietin and Anemia Treatment
- Vasculitis and related conditions
- Acute Kidney Injury Research
Meyer Children's Hospital
2023-2025
Meyer Children's Hospital
2011-2024
Ospedale Maggiore
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2021
University of Florence
1992-2017
RELX Group (United States)
2017
Boston Children's Hospital
2014
Meyer (China)
2009
Chronic kidney disease (CKD) is a major health problem worldwide. Although relatively uncommon in children, it can be devastating illness with many long-term consequences. CKD presents unique features childhood and may considered, at least part, as stand-alone nosologic entity. Moreover, some typical of paediatric CKD, such the aetiology or cardiovascular complications, will not only influence child's health, but also have impact on life adult that they become. In this review we focus issues...
The efficacy of continuous antibiotic prophylaxis in preventing urinary tract infection (UTI) infants with grade III, IV, or V vesicoureteral reflux is controversial. Download a PDF the Research Summary. In this investigator-initiated, randomized, open-label trial performed 39 European centers, we randomly assigned 1 to 5 months age and no previous UTIs receive (prophylaxis group) treatment (untreated for 24 months. primary outcome was occurrence first UTI during period. Secondary outcomes...
We report the recommendations for diagnosis, treatment, imaging evaluation and use of antibiotic prophylaxis in children with first febrile urinary tract infection, aged 2 months to 3 years. They were prepared by a working group Italian Society Pediatric Nephrology after careful review available literature consensus decision, when clear evidence was not available.These are endorsed Nephrology. can also be tool comparison other existing guidelines issues which much controversy still exists.
Visual Abstract Export Background and objectives Nephrotic syndrome is a typical presentation of genetic podocytopathies but occasionally other nephropathies can present as clinically indistinguishable phenocopies. We hypothesized that extended testing followed by reverse phenotyping would increase the diagnostic rate for these patients. Design, setting, participants, & measurements All patients diagnosed with nephrotic referred to our center between 2000 2018 were assessed in this...
Nephritis is a common manifestation of IgA vasculitis and morphologically indistinguishable from nephropathy. While MEST-C scores are predictive kidney outcomes in nephropathy, their value nephritis has not been investigated large multiethnic cohorts.
In children, sporadic nephrotic syndrome can be related to a genetic cause, but what extent alterations associate with resistance immunosuppression is unknown. this study, we designed custom array for next-generation sequencing analysis of 19 target genes, reported as possible causes syndrome, in cohort 31 children affected by steroid-resistant and 38 patients who exhibited similar steroid-sensitive clinical phenotype. Patients extrarenal symptoms, had familial history the disease or...
The critical role of genetic and epigenetic factors in the pathogenesis kidney disorders is gradually becoming clear, need for disease models that recapitulate human a personalized manner paramount. In this study, we describe method to select amplify renal progenitor cultures from urine patients with disorders. Urine-derived progenitors exhibited phenotype functional properties identical those purified tissue, including capacity differentiate into tubular cells podocytes, as demonstrated by...
Background and objectives ANCA-associated vasculitis is extremely rare in children. We report the clinicopathologic features, long-term outcomes, prognostic factors of a large pediatric cohort patients with kidney vasculitis. Design, setting, participants, & measurements This retrospective study included 85 consecutive biopsy specimen–proven from tertiary referral centers Italy Canada. Kidney specimens were categorized as focal, crescentic, sclerotic, or mixed, according to Berden...
Abstract Time to remission (TTR) has been largely considered one of the predictive factors for risk relapse and steroid dependency in childhood steroid-sensitive nephrotic syndrome, yet conflicting opinions exist. However, influencing TTR have never studied. We performed a post-hoc analysis prospective pediatric cohort enrolled previous multicenter study (ClinicalTrials.gov Id: NCT01386957) evaluate possible influence some clinical laboratory parameters at INS onset on timing TTR. A total...
The optimal therapeutic regimen for managing childhood idiopathic nephrotic syndrome (INS) is still under debate. We have evaluated the choice of steroid and symptomatic treatment adopted by pediatricians pediatric nephrologists in a large number centers as first step towards establishing shared protocolThis was multicenter, retrospective study. A total 231 children (132 admitted to units) aged 6 months <15 years who presented with onset 54 units six nephrology Italy between 2007 2009 were...
The incidence of gemcitabine-induced hemolytic uremic syndrome has already been described in adults. Several approaches have employed the treatment with different outcomes. One most promising agents is eculizumab, which a monoclonal antibody directed against C5 complement protein. We reported case 3-year-old white boy medulloblastoma who underwent high-dose chemotherapy and craniospinal irradiation. Afterwards he started maintenance gemcitabine oxaliplatin. After five courses presented...
Aim: of the study was to analyse impact SXR rs3842689 polymorphism on response corticosteroids in pediatric idiopathic nephrotic syndrome. Patients & methods: 66 children (56 steroid-sensitive, ten steroid-resistant) were studied for gene distribution. Results: Steroid sensitive patients accounted 96% cases with In/In polymorphism, but only 53% Del/Del At odds ratio analysis, represented a clear risk factor steroid resistance (OR: 20.57; p = 0.009), while favourable prognostic sensitivity....
We retrospectively analyzed etiological, pathological and clinical features of the patients with hemolytic uremic syndrome (HUS) observed in Pediatric Nephrology Unit at AOU Meyer Florence. From January 1997 to December 2008, 22 cases were identified, an annual incidence 0.05 per 100,000 inhabitants, 0.34 children <15 years old. 60% D+ 40% D-, age distribution from 12 days 13 years. Twenty (90%) had oligoanuria, lasting 6.4 ± 4 for versus 11.8 D- patients. The development chronic kidney...
No AccessJournal of UrologyPediatric Urology1 Jun 1996Alternative Approaches to the Prognostic Stratification Mild Moderate Primary Vesicoureteral Reflux in Children Roberto Sciagra, Marco Materassi, Vania Rossi, Rita Ienuso, Alfredo Danti, and Guiseppe La Cava SciagraRoberto Sciagra More articles by this author , MaterassiMarco Materassi RossiVania Rossi IenusoRita Ienuso DantiAlfredo Danti CavaGuiseppe View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66104-4AboutFull...