A5036649202- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Pericarditis and Cardiac Tamponade
- Biomarkers in Disease Mechanisms
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Myasthenia Gravis and Thymoma
- Infective Endocarditis Diagnosis and Management
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- Cardiovascular Disease and Adiposity
- Kawasaki Disease and Coronary Complications
- Renal and Vascular Pathologies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Contact Dermatitis and Allergies
- Autoimmune and Inflammatory Disorders Research
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Hematological disorders and diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral Infections and Immunology Research
- Retinal and Optic Conditions
- Pregnancy and Medication Impact
University of Milan
2019-2025
ASST Fatebenefratelli Sacco
2019-2025
Azienda Ospedaliera Fatebenefratelli e Oftalmico
2024
Fatebenefratelli Hospital
2020-2024
Luigi Sacco Hospital
2019-2023
Vita-Salute San Raffaele University
2013-2023
WinnMed
2023
Jacksonville College
2023
Mayo Clinic in Florida
2023
University of British Columbia
2023
Abstract The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a density comparable to that observed in infection, an dose just 3.7 mJ/cm 2 was sufficient achieve more than 3-log inactivation without any sign viral replication. Moreover, complete at all with 16.9 . These results could explain the epidemiological trends COVID-19 are important development novel...
Platelet microparticles from patients with systemic sclerosis prompt endothelial cell activation, neutrophil recruitment, and lung fibrosis.
Abstract Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health 1 . This is compounded by the limited efficacy available treatments high failure during drug development 2 , highlighting an urgent need better understand mechanisms. Here we show how functional genomics could address this challenge. By investigating intergenic haplotype on chr21q22—which has been independently linked bowel disease, ankylosing spondylitis, primary sclerosing...
Aims Novel therapies are needed for recurrent pericarditis, particularly when corticosteroid dependent and colchicine resistant. Based on limited data, interleukin-1 blockade with anakinra may be beneficial. The aim of this multicentre registry was to evaluate the broader effectiveness safety in a ‘real world’ population. Methods results This enrolled consecutive patients pericarditis who were resistant treated anakinra. primary outcome recurrence rate after treatment. Secondary outcomes...
The aim of our study was to evaluate the safety and efficacy tocilizumab (TCZ) for refractory Takayasu arteritis (TA).We retrospectively assessed outcome blocking interleukin (IL)-6 with TCZ in 7 consecutive patients TA using a combination clinical imaging assessment.During median followup visit at 14 months, 4 taking [including 2 nonresponders tumor necrosis factor (TNF) inhibitors] achieved response, suggesting nonredundant role IL-6 TA. Inflammatory markers normalized all treated TCZ....
Abstract Introduction Progression of arterial involvement is often observed in patients with Takayasu arteritis (TA) thought to be remission. This reflects the failure currently used biomarkers and activity criteria detect smouldering inflammation occurring within wall. Pentraxin-3 (PTX3) a soluble pattern recognition receptor produced at sites could reveal systemic as well localized inflammatory processes. We verified whether blood concentrations PTX3 C-reactive protein (CRP) might reflect...
The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a density comparable to that observed in infection, an dose just 3.7 mJ/cm 2 was sufficient achieve more than 3-log inactivation without any sign viral replication. Moreover, complete at all with 16.9 . These results could explain the epidemiological trends COVID-19 are important development novel sterilizing methods...
PTX3 is a prototypic soluble pattern recognition receptor, expressed at sites of inflammation and involved in regulation the tissue homeostasis. systemic levels increase many (but not all) immune-mediated inflammatory conditions. Research on as biomarker has so far focused single diseases. Here, we performed multi-group comparative study with aim identifying clinical pathophysiological phenotypes associated release. concentration was measured by ELISA plasma 366 subjects, including 96...
Objectives The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due part to small cohort sizes, a consequence the low prevalence vasculitides. This study aimed identify new genetic risk for main systemic vasculitides through comprehensive analysis their overlap. Methods Genome-wide data from 8467 patients any forms and 29 795 healthy controls were meta-analysed using ASSET. Pleiotropic variants functionally annotated linked...
Abstract Arterial involvement is the cardinal feature of large-vessel vasculitis (LVV) and prevention disease progression principal therapeutic goal. However, development tools for its evaluation represents a major unmet need. To address this, widely-applicable imaging tool LVV, analysing arterial in 17 territories, has been developed validated. Individual stenosis dilation scores were generated combined composite score. The methodology was validated cross-sectionally longitudinally 131...
Following influenza infection, rs2248374-G ERAP2 expressing cells may transcribe an alternative spliced isoform: ERAP2/Iso3. This variant, unlike ERAP2-wt, is unable to trim peptides be loaded on MHC class I molecules, but it can still dimerize with both ERAP2-wt and ERAP1-wt, thus contributing profiling cellular immune-peptidome. In order verify if the expression of ERAP2/Iso3 induced by other pathogens, PBMCs MDMs isolated from 20 healthy subjects were stimulated flu, LPS, CMV, HIV-AT-2,...
Biochemical and cytological pericardial fluid (PF) analysis is essentially based on the knowledge of pleural composition. The aim present study to identify reference intervals (RIs) for PF according state-of-art methodological standards.We prospectively collected analysed venous blood consecutive subjects undergoing elective open-heart surgery from July 2017 October 2018. Exclusion criteria enrolment were evidence diseases at preoperatory workup or intraoperatory assessment, any other...
Background and objectives ANCA-associated vasculitis is extremely rare in children. We report the clinicopathologic features, long-term outcomes, prognostic factors of a large pediatric cohort patients with kidney vasculitis. Design, setting, participants, & measurements This retrospective study included 85 consecutive biopsy specimen–proven from tertiary referral centers Italy Canada. Kidney specimens were categorized as focal, crescentic, sclerotic, or mixed, according to Berden...
To examine pericoronary adipose tissue (PCAT) and periaortic (PAAT) density on coronary computed tomography angiography for assessing arterial inflammation in Takayasu arteritis (TAK) atherosclerosis.PCAT PAAT was measured (n = 1016) aortic 108) segments from 108 subjects [TAK + artery disease (CAD), n 36; TAK, 18; atherosclerotic CAD, 32; matched controls, 22]. Median PCAT densities varied between groups (mPCAT: P < 0.0001; PAAT: 0.0002). 7.01 ± standard error of the mean (SEM) 1.78...
Takayasu arteritis (TA) is a rare and idiopathic large-vessel typically affecting young women which has important morbidity mortality. There are no animal models of TA pathogenesis still mysterious. Clinical assessment lacks accurate activity indexes based on the integration clinical, laboratory radiological data. rarity hampered randomized clinical trials achievement high-quality evidence to guide activity. Prevention vascular progression, with progressive vessel wall remodelling...