A5048894757- MicroRNA in disease regulation
- Nutrition and Health in Aging
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Failure Treatment and Management
- Microfluidic and Bio-sensing Technologies
- Parathyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Tissue Engineering and Regenerative Medicine
- Bone health and osteoporosis research
- Antiplatelet Therapy and Cardiovascular Diseases
- Biomarkers in Disease Mechanisms
- Analytical Chemistry and Sensors
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- GDF15 and Related Biomarkers
- Thyroid Disorders and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Congenital heart defects research
- Nonmelanoma Skin Cancer Studies
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Cutaneous Melanoma Detection and Management
- Ion Transport and Channel Regulation
Magna Graecia University
2015-2025
Azienda Ospedaliero Universitario Mater Domini
2021-2023
Ca' Foscari University of Venice
2020
University of Turin
2020
Hôpital Laennec
2006
UNSW Sydney
2002
New York University
1982-1990
Columbia University Irving Medical Center
1990
Bellevue Hospital Center
1982
Non-alcoholic fatty liver disease (NAFLD) is the most common worldwide, characterized by acid accumulation and fibrosis, not due to excessive alcohol consumption. Notably, nutritional habits have been reported be implicated in onset severity of hepatic damage, while Mediterranean diet has shown beneficial effects on NAFLD. Free radicals oxidative stress were suggested involved pathogenesis progression NAFLD, several data highlighted efficacy antioxidant supplementation its treatment. The aim...
Calorie restriction is a common strategy for weight loss in obese individuals. However, little known about the impact of moderate hypocaloric diets on obesity-related laboratory parameters short-term period. Aim this study was to evaluate variation biomarkers individuals following Mediterranean, (1400–1600 Kcal/die) diet. 23 obese, pharmacologically untreated patients were enrolled and subjected determination anthropometric variables blood collection at baseline, 1 4 months after diet...
Circulating oxidative stress and pro-inflammatory markers change after regular physical exercise; however, how a short session of acute activity affects the inflammatory status redox balance in sedentary individuals is still unclear. Aim this study to assess antioxidant parameters, both at rest exercise, young men with or without obesity. Thirty male volunteers, aged 20–45 (mean age 32 ± 7 years), were recruited, divided into 3 groups (normal weight: BMI < 25 kg/m2; overweight moderate...
Diabetes mellitus (DM) affects the biology of multipotent cardiac stem/progenitor cells (CSCs) and adult myocardial regeneration. We assessed hypothesis that senescence senescence-associated secretory phenotype (SASP) are main mechanisms degenerative defect in DM. Accordingly, we tested whether ablation senescent CSCs would rescue regenerative/reparative imposed by obtained tissue from nonaged (50- to 64-year-old) patients with type 2 diabetes (T2DM) without DM (NDM) postinfarct...
Introduction—The purpose of this study was to determine the relative impact modifiable and non-modifiable risk factors in development gestational diabetes mellitus (GDM), with a particular focus on maternal preconception body mass index (BMI) age, two important determinants insulin resistance. Understanding that contribute most current escalation GDM rates pregnant women could help inform prevention intervention strategies, particularly areas where female endocrine disorder has an elevated...
Background: Non-alcoholic fatty liver disease is the most common worldwide. Aim: The aim of this study to compare metabolic effects Mediterranean diet versus associated with silybin, phosphatidylcholine and vitamin E complex in overweight patients non-alcoholic disease. Methods: Thirty Caucasian were randomized into three groups 10 (Groups A, B C). A personalized was started Group patients. In association diet, given Realsil complex, daily, for 6 months. C refused any treatment. Results: We...
Abstract Introduction Progression of arterial involvement is often observed in patients with Takayasu arteritis (TA) thought to be remission. This reflects the failure currently used biomarkers and activity criteria detect smouldering inflammation occurring within wall. Pentraxin-3 (PTX3) a soluble pattern recognition receptor produced at sites could reveal systemic as well localized inflammatory processes. We verified whether blood concentrations PTX3 C-reactive protein (CRP) might reflect...
Oleuropein (OLE) is the major phenolic secoiridoid of olive tree leaves, and its antioxidant anti-inflammatory activities have been demonstrated in vitro vivo animal models. The aim this study was to investigate activity OLE colonic mucosa from patients with ulcerative colitis (UC). Biopsies obtained during colonoscopy 14 active UC were immediately placed an organ culture chamber challenged lipopolysaccharide Escherichia coli (EC-LPS) at 1 μg/mL presence or absence 3 mM OLE. expression...
In the last few years, bone has been recognized as an endocrine organ that modulates glucose metabolism by secretion of osteocalcin, osteoblast-specific hormone, influences fat deposition and blood sugar levels. To date, however, very in vitro models have developed to investigate, at molecular levels, relationship between glucose, insulin osteocalcin. This study aims covering this gap. We studied osteogenic differentiation, osteocalcin gene expression, osteblast-mediated secretion, using...
Alterations of the immune system are known in eating disorders (EDs), however importance cytokine balance this context has not been clarified. We compared cytokines and growth factors at opposite ends BMI ranges, 90 patients classified relation to BMI, depressive EDs comorbidities. Serum concentrations interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), vascular endothelial...
To assess the reliability of CXR and to describe findings clinical laboratory characteristics associated with positive negative CXR.Retrospective two-center study on consecutive patients admitted emergency department two north-western Italian hospitals in March 2020 suspicion COVID-19 confirmed by RT-PCR who underwent within 24 h swab execution. 260 (61% male, 62.8 ± 15.8 year) were enrolled. CXRs rated as (CXR+) or (CXR-), features reported included presence distribution airspace opacities,...
Objective: Recently, the role of circulating miRNAs as noninvasive biomarkers for identification and monitoring diabetes microvascular complications has emerged. Herein, we aimed to: identify differentially expressed in patients with without diabetic retinopathy (DR); examine their predictive value; understand pathogenic impact. Methods: Pooled serum samples from randomly selected matched type 2 diabetes, either or DR, were used initial plasma miRNA profiling. Validation most relevant was...
Background: Type 2 diabetes mellitus (T2DM) is characterized by a prothrombotic state, predisposing to vascular complications. Some related markers, linking thrombophilia hemostasis and inflammation, however, have been poorly explored in relation patients’ glycemia. We therefore investigated the association of laboratory hemostatic parameters, circulating adhesion molecules (ADMs), white blood cell (WBC) count, neutrophil/lymphocyte ratio (NLR) with T2DM glycemic control. Research design: In...
Abstract Recently, it has been shown that some well-known pathogenic mediators in rheumatoid arthritis (RA), such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), could play a role insulin resistance (IR) type 2 diabetes (T2D). In this 6-month longitudinal study, we aimed at investigating if the inhibition of IL-1 or TNF is associated with an improvement IR RA patients comorbid T2D possible effects on selected serum adipokines. were recruited among those undergoing treatment...
Nesfatin-1 is a new anorexigenic neuropeptide involved in the regulation of hunger/satiety, eating, and affective disorders. We aimed to investigate nesfatin-1 secretion vitro, murine adipose cells, human fat samples, as well assess link between circulating levels, NUCB2 Fat Mass Obesity Gene (FTO) polymorphisms, BMI, Eating Disorders (EDs), pathological behaviors. was evaluated both normoxic fully differentiated 3T3-L1 mouse adipocytes after incubation under hypoxic conditions for 24 h....
Numerous studies have investigated the role of dietary factors in prevention cognitive decline but short-term effects foods choice on performances elderly are poorly explored. Our aim was to investigate among Italian individuals and association with function. In this longitudinal study, participants were 214 aged ≥65 years a score >20 at Mini Mental State Examination. The sub-test ADAScale used detect progression over 12 months. Food choices measured by combination 24-h recall seven-day diet...
Aims: Heart failure is a clinical syndrome characterized by subclinical systemic inflammation and immune system activation associated with iron deficiency. No data exist on the various activations of immune-mediated mechanisms in heart patients reduced/preserved ejection fraction. We aimed to (1) investigate possible differences inflammatory parameters oxidative stress, (2) detect different status between groups. Materials Methods: enrolled 50 consecutive Caucasian outpatients failure. All...
Background and aim-Alterations in circulating microRNA (miRNA) expression patterns are thought to be involved the early stages of prediabetes, as well progression overt type 2 diabetes mellitus (T2D) its vascular complications. However, most research findings conflicting, part due differences miRNA extraction normalization methods, study populations their selection. This cross-sectional seeks find new potentially useful biomarkers predict and/or diagnose T2D by investigating differential...