A5077564004- Cardiac Arrhythmias and Treatments
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Ion Transport and Channel Regulation
- Atrial Fibrillation Management and Outcomes
- Biomedical Research and Pathophysiology
- Mechanical Circulatory Support Devices
- Cardiac pacing and defibrillation studies
- Kidney Stones and Urolithiasis Treatments
- Hepatitis B Virus Studies
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Porphyrin Metabolism and Disorders
- Parathyroid Disorders and Treatments
- HIV/AIDS drug development and treatment
- Renal Diseases and Glomerulopathies
- Genetic and Kidney Cyst Diseases
- Pancreatic function and diabetes
- Inflammatory mediators and NSAID effects
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Health and Disease Prevention
- Renal function and acid-base balance
- Metabolomics and Mass Spectrometry Studies
- Immune Response and Inflammation
Ospedale Generale Regionale Francesco Miulli
2019-2025
Ospedale di Circolo di Busto Arsizio
2024
Ospedale Papa Giovanni XXIII
2014-2023
University of Salerno
2017-2020
Fondazione Poliambulanza Istituto Ospedaliero
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Azienda Ospedaliera San Gerardo
2013-2016
University of Bergamo
2009-2011
University of Milano-Bicocca
2011
Azienda Ospedaliero Universitaria Ospedali Riuniti
2008-2011
Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment long-term outcome. We contacted paediatric adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic clinical in an online form. Adequate were collected 340 patients (29 countries, female 52%). Mutation testing had been performed 206 (61%); pathogenic mutations identified 170 (83%). The median (range) presentation age...
Recent studies report a prevalence of non-alcoholic fatty liver disease (NAFLD) between 70% and 80% in patients with metabolic syndrome (MS) type 2 diabetes mellitus (T2DM). Nevertheless, it is not possible to differentiate simple steatosis steatohepatitis (NASH) non-invasive tests. The aim this study was NASH by biopsy hypertransaminasemia MS or T2DM. Two hundred fifteen increased ALT levels MS, 136 at their first diagnosis T2DM regardless values were consecutively admitted tertiary...
Glomerulopathy with fibronectin (FN) deposits (GFND) is an autosomal dominant disease age-related penetrance, characterized by proteinuria, microscopic hematuria, hypertension, and massive glomerular of FN that lead to end-stage renal failure. The genetic abnormality underlying GFND was still unknown. We hypothesized mutations in FN1, which encodes FN, were the cause GFND. In a large Italian pedigree eight affected subjects, we found linkage at FN1 locus 2q32. sequenced 15 unrelated...
The association of hepatitis C virus (HCV) with non-Hodgkin's lymphoma (NHL) has been demonstrated throughout the world. new interferon-free direct antiviral agents (DAAs) showed high efficacy and safety, preliminary data seem to confirm their activity on low-grade NHL. question arises as whether or not-and how-to treat HCV-positive patients suffering from diffuse large B-cell lymphomas (DLBCLs). aim this observational study was evaluate DAA treatment DLBCL/HCV-infected in concomitance...
Secondary hyperparathyroidism contributes to post-transplant CKD mineral and bone disorder. Paricalcitol, a selective vitamin D receptor activator, decreased serum parathyroid hormone levels proteinuria in patients with secondary hyperparathyroidism. This single-center, prospective, randomized, crossover, open-label study compared the effect of 6-month treatment paricalcitol (1 μg/d for 3 months then uptitrated 2 µg/d if tolerated) or nonparicalcitol therapy on (primary outcome), metabolism,...
Tolvaptan and octreotide-long-acting release (LAR) have renoprotective effects in autosomal dominant polycystic kidney disease (ADPKD) that are partially mediated by amelioration of compensatory glomerular hyperfiltration. We compared the tolvaptan octreotide-LAR combination therapy versus those monotherapy patients with ADPKD.
Background Cardioneuroablation (CNA) is a new approach to treat reflex syncope and functional bradyarrhytmias caused by autonomic imbalance. We report our experience using CNA. Method From September 2022 July 2023, we took care of 21 patients (mean age 42 ± years; 62% male) affected or bradyarrhythmias. All underwent CNA under conscious sedation targeting the superior and/or inferior paraseptal ganglionated plexus (GPs). Results Nine were vasovagal (VVS) twelve In 3 cases (14%) ablation was...
Standard diet with normal calcium and reduced animal proteins salt content reduces stone recurrence in oxalate nephrolithiasis. Whether lemon juice supplementation further rate is unknown.In this single-centre, prospective, randomised, open, blinded endpoint trial (Clinical Trials gov NCT01217372) we evaluated the effects of fresh (60 mL twice daily) versus no supplementation, on time to 203 patients recurrent idiopathic nephrolithiasis who were all prescribed a standard diet. Patients...
Background. Medullary sponge kidney (MSK) is a rare congenital disease characterized by diffuse ectasia or dilation of precalyceal collecting tubules. Although its pathogenesis unknown, the association with various diseases suggests that it could be developmental disorder. In addition to typical clinical features nephrocalcinosis and urolithiasis, patients MSK show tubular function defects acidification concentration. These are considered secondary morphological changes Primary distal renal...
Vitamin D receptor activator (VDRA) therapy has been shown to be associated with reduced mortality rates in chronic kidney disease (CKD) patients secondary hyperparathyroidism (SHPT). However, differences between VDRAs their ability reduce both all-cause and cardiovascular-related are not yet fully elucidated.The objective of the current analysis was determine effect VDRA on an Italian dialysis population, observed prospectively every 6 months for 18 months. Patients were investigated risk...
(1) Background: The emergency linked to the spread of COVID-19 in Italy has led inevitable consequences on penitentiary system. risks this prisons is mainly related problem persistent overcrowding that makes social distancing difficult and isolation any contagion hard arrange. Department Protection for Adults Minors ASL Salerno Criminal Area taken steps order perform screening operations minimize prisoners operators. (2) Methods: We conducted a two-phase observational study. In first phase,...
Awareness of radiation exposure risks associated to interventional cardiology procedures is growing. The availability new technologies in electrophysiology laboratories has reduced fluoroscopy usage during arrhythmias ablations. aim this study was describe with and without X-Rays assess feasibility, safety, short-term efficacy zero intervention a high-volume center oriented keep ionizing as low reasonably achievable.
Inflammatory response and hemodilution are the main drawbacks of extracorporeal circulation. We hypothesize that use miniaturized circulation (MECC) might lower systemic myocardial inflammatory patterns compared with a standard system (SECC) off-pump coronary artery bypass grafting (OPCABG). Sixty-one patients undergoing isolated graft were prospectively randomized to MECC (n = 19), SECC 20), or OPCABG 22). Blood samples collected from radial sinus analyze blood lactate, hemodilution,...
Abstract Renal Cysts and Diabetes Syndrome (RCAD) is an autosomal dominant disorder caused by mutations in the HNF1B gene encoding for transcriptional factor hepatocyte nuclear factor-1B. RCAD characterized as a multi-organ disease, with broad spectrum of symptoms including kidney abnormalities (renal cysts, renal hypodysplasia, single kidney, horseshoe kidneys, hydronephrosis), early-onset diabetes mellitus, abnormal liver function, pancreatic hypoplasia genital tract malformations. In...
Abstract Introduction Catheter ablation is an important treatment option for sustained ventricular arrhythmias (VA) that are refractory to pharmacological treatment; however, patients with fast VA or electrical storm (ES) at risk cardiogenic shock. We report our experience using cardiopulmonary support extracorporeal membrane oxygenation (ECMO) during catheter of VA. Methods Nineteen (mean age, 62 ± 10 years; 84% male) were referred center CA ES between January 2017 and April 2018. was...
Background: Catheter ablation is a treatment option for sustained ventricular tachycardias (VTs) that are refractory to pharmacological treatment; however, patients with fast VT and electrical storm (ES) at risk cardiogenic shock. We report our experience using cardiopulmonary support extracorporeal membrane oxygenation (ECMO) during catheter of VT. Methods: Sixty-two (mean age 68 ± 9 years; 94% male) were referred center repeated episodes hemodynamically unstable arrhythmias. ES was defined...