A5101547287- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- Advanced MRI Techniques and Applications
- Renal Diseases and Glomerulopathies
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Urology and Nephrology Studies
- Glioma Diagnosis and Treatment
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Renal cell carcinoma treatment
- Endometrial and Cervical Cancer Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Lupus Erythematosus Research
- Cerebrospinal fluid and hydrocephalus
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic and Kidney Cyst Diseases
- Medical Imaging Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Uterine Myomas and Treatments
- COVID-19 diagnosis using AI
- Digital Imaging for Blood Diseases
- Breast Lesions and Carcinomas
- Lymphoma Diagnosis and Treatment
- Gene Regulatory Network Analysis
- Fetal and Pediatric Neurological Disorders
Friedrich-Alexander-Universität Erlangen-Nürnberg
2024-2025
Universitätsklinikum Erlangen
2024
University Medical Center Freiburg
2024
University of Freiburg
2024
Mario Negri Institute for Pharmacological Research
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Institute for Magnetospheric Physics
2023
Azienda Ospedaliero-Universitaria Careggi
1991-2011
European Institute of Oncology
1992-2009
Glioblastomas are invasive brain tumors with high therapeutic resistance. Neuron-to-glioma synapses have been shown to promote glioblastoma progression. However, a characterization of tumor-connected neurons has hampered by lack technologies. Here, we adapted retrograde tracing using rabies viruses investigate and manipulate neuron-tumor networks. Glioblastoma rapidly integrated into neural circuits across the brain, engaging in widespread functional communication, cholinergic driving...
A prospective study was designed to determine the sensitivity and specificity of nonenhanced T2-weighted contrast material-enhanced T1-weighted magnetic resonance (MR) imaging in assessing depth myometrial invasion patients with proved endometrial cancer. In 56 consecutive clinically determined early-stage disease, findings two MR techniques were compared results histologic examination surgical specimens. Myometrial classified as absent (stage IA), superficial IB), or deep IC). assessment...
Tolvaptan and octreotide-long-acting release (LAR) have renoprotective effects in autosomal dominant polycystic kidney disease (ADPKD) that are partially mediated by amelioration of compensatory glomerular hyperfiltration. We compared the tolvaptan octreotide-LAR combination therapy versus those monotherapy patients with ADPKD.
Abstract The diagnostic landscape of brain tumors integrates comprehensive molecular markers alongside traditional histopathological evaluation. DNA methylation and next-generation sequencing (NGS) have become a cornerstone in central nervous system (CNS) tumor classification. A limiting requirement for NGS profiling is sufficient quality quantity, which restrict its feasibility. Here we demonstrate NePSTA (neuropathology spatial transcriptomic analysis) morphological neuropathological...
PURPOSE: To determine the value of magnetic resonance (MR) imaging in follow-up small (< 3 cm) hepatocellular carcinoma treated with percutaneous ethanol injection (PEI). MATERIALS AND METHODS: Fifty-seven patients underwent MR before and after PEI. At every 6 months, images were correlated results fine-needle aspiration biopsy (FNAB). In 12 patients, correlation histologic findings surgical specimens was possible. RESULTS: 39 followed up for 24 lesions showed hypointensity on unenhanced...
To assess the potential role of magnetic resonance (MR) imaging in follow-up evaluation small hepatocellular carcinoma (HCC) treated with percutaneous ethanol injection (PEI), 31 patients a single HCC lesion less than 3.0 cm diameter underwent MR at 0.5 T before and after treatment. Posttreatment included contrast material-enhanced computed tomography (CT) fine-needle biopsy all cases. The most important characteristic lesions was hypointensity on T2-weighted images cases (27 31) which...
Glioblastomas are heterogeneous brain tumors, notorious for their invasive behavior and resistance to therapy. Neuron-to-glioma synapses have been identified promote glioblastoma invasion proliferation. However, a comprehensive characterization of tumor-connected neurons has hampered by lack technologies. Here, we adapted retrograde tracing with modified rabies virus system characterize manipulate connected neuron-tumor networks. Glioblastoma rapidly integrated into neural circuits across...
This multicentre study aimed at assessing multi-vendor accuracy and reproducibility of typical MR biomarkers on 3T 1.5T scanners from 5 clinical centers. MRI acquisitions were performed using NIST protocols, Essential System Diffusion phantoms. T1 was measured by 3-parameter fitting, while T2 ADC mono-exponential PhantomViewer software. When compared with reference values, non-negligible discrepancies found across vendors, especially for measurements. Reproducibility vendor-dependent, higher...
This study investigates the correlation between MRI and histologic clinical findings in 7 patients with C3 glomerulopathy immune complex–associated membranoproliferative glomerulonephritis, rare diseases denoted by poor prognosis no specific therapies. Patients underwent repeated kidney MRI, biopsy, laboratory testing. Kidney diffusivity perfusion were assessed diffusion-weighted phase-contrast MRI. Laboratory parameters changed very differently from case to over 1 year. Perfusion biomarkers...
Abstract BACKGROUND Glioblastoma (GBM) stands as the most aggressive tumor of CNS. Current treatment typically involves surgical intervention followed by cycles Temozolomide (TMZ) chemotherapy in combination with radiotherapy. However, efficacy these treatments remains limited due to GBM’s ability adapt and resist therapy. TMZ leads significant alterations cell cycle GBM cells, a decrease cells G0-G1 phase an increase S or G2 phases. This shift distribution suggests dual response: re-entry...
Abstract BACKGROUND In recent years, spatially resolved, high-dimensional methodologies have elucidated substantial transcriptional heterogeneity within malignant brain tumors. However, the absence of functional readouts has impeded linkage emergent insights from cancer neuroscience to structural observed. To address these challenges, we developed a novel methodology that combines resolved electrophysiological recordings with array-based transcriptomics on surgical specimens. This approach...
Abstract BACKGROUND The structured layers of the human neocortex stand in sharp contrast to disordered arrangement found malignant CNS tumors. Glioblastoma (GBM), with its diverse characteristics, presents formidable hurdles both research and treatment, as successful approaches demand a uniform biological understanding. In this study, we capitalize on recent advances spatial biology, employing integrated spatially resolved transcriptomics metabolomics identify factors driving unique...
Abstract The organized layered structure of the human neocortex contrasts sharply with chaotic architecture malignant CNS tumors. heterogenous nature glioblastoma (GBM) poses significant challenges to research and treatment, given that effective strategies require consistent biological patterns. Here, we leverage recent advances in spatial biology, integrating spatially resolved transcriptomics metabolomics identify drivers GBM-specific architectural evolution. We performed (MALDI) (Visium...
Abstract Glioblastomas are primary brain tumors known for their whole-brain invasion and high therapeutic resistance. In previous studies, neuron-to-glioma synapses have been shown to promote glioblastoma progression. A deep characterization of this communication tumor-connected neurons has not possible due technological limitations. We adapted a rabies virus-based retrograde tracing approach investigate manipulate neuron-tumor networks. Interestingly, we found that cells rapidly integrated...
Primary membranoproliferative glomerulonephritis (MPGN) is a rare kidney disease with poor prognosis and no specific therapies. The heterogeneity the difficulty of performing repeated biopsies pose big challenges. This study investigates correlation between non-contrast enhanced magnetic resonance imaging (MRI) histologic clinical findings in patients primary MPGN.
Perilesional edema (PE) is commonly observed in association with an intracranial mass. PE thought to be determined by vasogenic effects the cerebral parenchyma surrounding mass due loss or absence of blood-brain barrier (BBB) inside lesion. Alterations capillary permeability induce extrusion fluids into extravascular space around On Computed Tomography (CT) corresponds area low density for increased water content, outside margins It difficult differentiate from areas parenchymal compressive...