A5040137823- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Medical Education and Admissions
- Spinal Fractures and Fixation Techniques
- Cell Image Analysis Techniques
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Global Health Workforce Issues
- Innovations in Medical Education
- Traumatic Brain Injury Research
- Brain Tumor Detection and Classification
- Protein Degradation and Inhibitors
- Management of metastatic bone disease
- Spine and Intervertebral Disc Pathology
- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Renal cell carcinoma treatment
- Cerebrospinal fluid and hydrocephalus
- Intraoperative Neuromonitoring and Anesthetic Effects
- Biomedical and Chemical Research
- Cancer, Hypoxia, and Metabolism
- Optical Imaging and Spectroscopy Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
University Hospital Heidelberg
2018-2025
Heidelberg University
2018-2025
Heidelberg University
2025
Brain (Germany)
2021-2024
German Cancer Research Center
2021-2024
German Medical Association
2018
Glioblastomas are invasive brain tumors with high therapeutic resistance. Neuron-to-glioma synapses have been shown to promote glioblastoma progression. However, a characterization of tumor-connected neurons has hampered by lack technologies. Here, we adapted retrograde tracing using rabies viruses investigate and manipulate neuron-tumor networks. Glioblastoma rapidly integrated into neural circuits across the brain, engaging in widespread functional communication, cholinergic driving...
Glioblastoma is the most common primary malignancy of central nervous system with a dismal prognosis. Genomic signatures classify isocitrate dehydrogenase 1 (IDH)-wildtype glioblastoma into three subtypes: proneural, mesenchymal, and classical. Dasatinib, an inhibitor proto-oncogene kinase Src (SRC), one many therapeutics which, despite promising preclinical results, have failed to improve overall survival in patients clinical trials. We examined whether subtypes differ their response...
Surgery for recurrent glioma provides cytoreduction and tissue molecularly informed treatment. With mostly heavily pretreated patients involved, it is unclear whether the benefits of repeat surgery outweigh its potential risks.
<title>Abstract</title> DNA methylation analysis has become an essential diagnostic assay for classifying tumours of the central nervous system (CNS). However, this test requires additional resources and time compared to conventional histopathological diagnosis using haematoxylin eosin (H&E) stained tissue sections, which are available globally. Here, we propose reduce resource requirements Hetairos, artificial intelligence (AI) algorithm that predicts 102 methylation-based CNS tumour...
Background/Objectives: Traumatic spinal cord injury (TSCI) profoundly impacts patients by precipitating a loss of motor and sensory capabilities, largely due to oxidative stress inflammation during the secondary phase. Methods: This investigation explores diagnostic potential zinc (Zn) free (fZn) as biomarkers analyzing their serum concentration dynamics in 48 TSCI individuals with TSCI, aim correlating these levels neurological impairment. Serum samples collected at admission, 4 h, 9 12 24...
Abstract Background Spinal hemangioblastomas (sHBs) are rare vascular tumors with significant neurological implications. Their management, particularly in von Hippel-Lindau (VHL) disease, remains challenging due to recurrence and functional decline. Timely identification intervention critical for optimal outcomes. Methods This international, multicenter retrospective cohort study included 357 patients (199 VHL-associated, 158 sporadic) from 13 neuro-oncological centers. Clinical imaging data...
Importance The optimal timing for fixation of extremity fractures after traumatic brain injury (TBI) remains controversial. Objective To investigate whether patients who underwent within 24 hours TBI experienced worse outcomes than those had the procedure or more TBI. Design, Setting, and Participants This cohort study used data from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Patients 16 years older with internal met inclusion...
Glioblastomas are heterogeneous brain tumors, notorious for their invasive behavior and resistance to therapy. Neuron-to-glioma synapses have been identified promote glioblastoma invasion proliferation. However, a comprehensive characterization of tumor-connected neurons has hampered by lack technologies. Here, we adapted retrograde tracing with modified rabies virus system characterize manipulate connected neuron-tumor networks. Glioblastoma rapidly integrated into neural circuits across...
Paraparesis due to oncologic lesions of the spine warrants swift neurosurgical intervention prevent permanent disability and hence maintain independence affected patients. Clinical parameters that predict a favorable outcome after surgical could aid decision-making in emergency situations.Patients who underwent for paraparesis (grade muscle strength <5 according British Medical Research Council grading system) secondary spinal neoplasms between 2006 2020 were included single-center...
Abstract Purpose With the increasing role of molecular genetics in diagnostics intracranial tumors, delivering sufficient representative tissue for such analyses is paramount importance. This study explored rate successful diagnosis after frame-based stereotactic biopsies lesions. Methods Consecutive patients undergoing 2020 and 2021 were included this retrospective analysis. Cases classified into three groups: conclusive, with missing (MG) data, inconclusive neuropathological diagnosis....
Activation of the interleukin-4 (IL-4) pathway ameliorates secondary injury mechanisms after experimental traumatic brain (TBI); therefore, we assessed effect a therapeutic IL-4 administration on damage TBI. We subjected 100 C57/Bl6 wildtype mice to controlled cortical impact (CCI) and administered or placebo control subcutaneously 15 min thereafter. Contusion volume (Nissl staining), neurological function (hole board, video open field, CatWalkXT®), immune response (immunofluorescent...
OBJECTIVE Spinal intramedullary ependymomas (IEs) represent a well-defined tumor entity usually warranting resection. Factors that determine full long-term neurological recovery after resection are seldomly reported on in larger clinical series. In this study, the authors aimed to highlight outcome of patients with IEs resection, focus recovery, and explore possible risk factors for absence amelioration an optimal function surgical treatment. METHODS A single-center retrospective analysis...
Abstract Background Even though mechanical recanalization techniques have dramatically improved acute stroke care since the pivotal trials of decompressive hemicraniectomy for malignant courses ischemic stroke, remains a mainstay treatment. However, it is still unclear whether prior thrombectomy, which in most cases associated with application antiplatelets and/or anticoagulants, affects surgical complication rate and conclusions derived from are valid times modern care. Methods A total 103...
Objective Spine injury is highly prevalent in patients with poly-trauma, but data on the co-occurrence of spine trauma traumatic brain (TBI) are scarce. In this study, we used Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) database to assess prevalence, characteristics, and outcomes TBI a concurrent spinal (TSI). Methods Data from multi-center CENTER-TBI study were analyzed. Adult (≥18 years) presenting concomitant, isolated TSI at least serious...
The new project "International Medical Students" within the German Students' Association (bvmd) aims at connecting local support programs for international medical students as well representation of their interests bvmd. Within frame this project, first symposium Students - Support Programs in Practical Application" took place from 12th to 14th May 2017 Hannover School (MHH). Through partaking different workshops, 31 participants discussed framework conditions work (i.e. curricula,...
Einleitung: Sekundäre Verletzungsprozesse nach Rückenmarksverletzungen (SCI) hemmen das Wachstum von Neuriten, was die funktionelle Erholung begrenzt. Die Transplantation neuronalen Vorläuferzellen (NPCs) hat positive Auswirkungen auf Neuroregeneration gezeigt, möglicherweise durch ihr Sekretom. Ziel dieser Arbeit war es deshalb, Exosomen NPCs (NPC-Exos) zu isolieren und charakterisieren, Potenzial zur Förderung des Neuritenwachstums in vitro untersuchen sie als regenerative Therapie der SCI...