A5076992912- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- MRI in cancer diagnosis
- Lanthanide and Transition Metal Complexes
- Solid-state spectroscopy and crystallography
- Cardiovascular Function and Risk Factors
- NMR spectroscopy and applications
- Renal and Vascular Pathologies
- Acute Kidney Injury Research
- Ultrasound and Hyperthermia Applications
- Advanced Neuroimaging Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Organ Transplantation Techniques and Outcomes
- Nuclear Physics and Applications
- Diabetes Treatment and Management
- Enzyme Structure and Function
- Medical Imaging Techniques and Applications
- Coffee research and impacts
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Radiomics and Machine Learning in Medical Imaging
- Mitochondrial Function and Pathology
- Renal function and acid-base balance
Aarhus University
2016-2025
Aarhus University Hospital
2014-2024
University of Southern Denmark
2022
RELX Group (United States)
2020
International Society of Nephrology
2020
Copenhagen University Hospital
2012-2017
Hvidovre Hospital
2012-2017
Debre Tabor University
2013
Technical University of Denmark
2012
Abstract Objectives This study aimed at developing technical recommendations for the acquisition, processing and analysis of renal ASL data in human kidney 1.5 T 3 field strengths that can promote standardization perfusion measurements facilitate comparability results across scanners multi-centre clinical studies. Methods An international panel 23 experts followed a modified Delphi process, including on-line surveys two in-person meetings, to formulate series consensus statements regarding...
Abstract To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) transverse (T2) relaxation time mapping. A multidisciplinary panel consisting 18 experts in field T1 T2 mapping participated a consensus project, which was initiated by European Cooperation Science Technology Action PARENCHIMA CA16103. Consensus were formulated using two-step modified Delphi method. The first survey consisted 56 items mapping, 4 reached pre-defined threshold 75% or...
Abstract MRI with hyperpolarized (HP) 13 C agents, also known as HP MRI, can measure processes such localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, recent rapid growth largely based on increasing availability of agent preparation methods suitable for use humans. This paper aims to capture current successful practices [1‐ C]pyruvate—by far most commonly used agent, which sits...
The strong enhancement of NMR signals achieved by hyperpolarization decays, at best, with a time constant few minutes. Here, we show that combination long-lived singlet states, molecular design, magnetic field cycling, and specific radiofrequency pulse sequences allows repeated observation the same batch polarized nuclei over period 30 min more. We report recycling protocol in which enhanced nuclear polarization dissolution-DNP is observed full intensity then returned to order. MRI...
Abstract Background This experimental study explores a novel magnetic resonance imaging/spectroscopic (MRI/MRS) method that measures changes in renal metabolism diabetic rat model. hyperpolarized metabolic MRI/MRS allows monitoring of processes seconds by >10 000‐fold enhancement the MR signal. The has shown conversion pyruvate to bicarbonate, i.e. dehydrogenase (PDH) activity, is significantly altered myocardium already at onset diabetes, and predominant Warburg effect valuable cancer...
Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental thermodynamic limitations of conventional magnetic resonance, and is translating to human studies several early-phase clinical trials in progress including early reports that demonstrate utility technique observe lactate production brain cancer patients. Owing coupling metabolism tissue function, metabolic neuroimaging hyperpolarised [1-
Abstract Purpose The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on MRI. Methods A task force was formed in July 2018 focused five methods. draft attaining distributed publicly consultation finalised at an open meeting (Prague, October 2018). Four expert panels completed surveys between March 2019, discussed...
The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are functionally characterized using biomarkers, capturing an vivo profile reflecting the disease's initial preclinical phase. Mutations SORL1, encoding endosome recycling receptor SORLA, found 2%–3% of individuals with early-onset AD, SORL1 haploinsufficiency appears to be for AD. To test whether can function as AD gene, we use CRISPR-Cas9-based gene editing develop a model Göttingen minipigs, taking advantage...
To describe neurophysiological abnormalities in Long COVID and correlate quantitative electromyography (qEMG) single fiber EMG (sfEMG) results to clinical scores histopathology. 84 patients with non-improving musculoskeletal symptoms were examined qEMG sfEMG. Muscle biopsies taken a subgroup. Mean motor unit potential (MUP) duration was decreased ≥ 1 muscles 52 % of the patients. jitter increased 17 tibialis anterior 25 extensor digitorum communis. Increased seen or without myopathic qEMG....
The aim of this study was to determine if hyperpolarized [1,4-
To evaluate the effect of treatment with semaglutide and empagliflozin on cortico-medullary sodium gradient (MCR; medulla/cortex ratio), urine sodium/creatinine ratio (UNACR), estimated plasma volume (ePV) to compare MCR between persons without type 2 diabetes.
This study aims to investigate the effects of β-3-hydroxybutyrate (β-3-OHB) infusion on myocardial metabolic flexibility using hyperpolarized [2-13C]pyruvate magnetic resonance spectroscopy (MRS) in pig heart. We hypothesized that β-3-OHB will cause rapid, quantifiable alterations tricarboxylic acid (TCA) cycle flux as measured non-invasively by 13C MRS and reflect work. Five female Danish landrace pigs underwent during a hyperinsulinemic euglycemic clamp (HEC). Cardiac metabolism...
Assessment of liver function is essential before partial hepatectomy to predict the risk post failure, a severe and life-threatening complication. Traditional methods have focused on expected future remnant (FLR) volume estimation. However, does not always correlate with function. We suggest that metabolism might be better surrogate for than volume. Therefore, we aimed investigate metabolic changes in porcine model portal vein ligation (PVL) using hyperpolarized magnetic resonance imaging...
Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney (AKI), and at present, there lack reliable biomarkers that can diagnose AKI measure early progression because the commonly used methods cannot evaluate single-kidney IRI. Hyperpolarized [1,4-13C2]fumarate conversion to [1,4-13C2]malate by fumarase has been proposed as necrosis in rat tumor models chemically induced rats. Here we show degradation cell membranes connection with leads elevated activity plasma urine...
Good glycemic control is crucial to prevent the onset and progression of late diabetic complications, but insulin treatment often fails achieve normalization level seen in healthy controls. In fact, recent experimental studies indicate that insufficient with insulin, resulting poor control, has an additional effect on than its own. We therefore compared renal metabolic alterations during conditions without suboptimal administration, which did not restore streptozotocin (STZ)-diabetic rats...
Renal ischemia-reperfusion injury is the state of which a tissue experiences after phase restrictive blood supply and recirculation. Ischemia-reperfusion (I/R-I) leading cause acute kidney (AKI) in several disease states, including transplantation, sepsis, hypovolemic shock. The most common methods to evaluate AKI are creatinine clearance, plasma creatinine, urea nitrogen, or renal histology. However, currently, there no precise directly assess noninvasively. Hyperpolarized 13C-pyruvate MRI...