A5091841722- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Electron Spin Resonance Studies
- MRI in cancer diagnosis
- Diet and metabolism studies
- Pediatric Urology and Nephrology Studies
- Lanthanide and Transition Metal Complexes
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Adrenal Hormones and Disorders
- Electrolyte and hormonal disorders
- Sirtuins and Resveratrol in Medicine
- Cardiac Valve Diseases and Treatments
- Hormonal Regulation and Hypertension
- Angiogenesis and VEGF in Cancer
- Advanced Neuroimaging Techniques and Applications
- Urinary Bladder and Prostate Research
- Ion Transport and Channel Regulation
- Birth, Development, and Health
- Atomic and Subatomic Physics Research
- Cancer, Hypoxia, and Metabolism
- Diet, Metabolism, and Disease
- Coffee research and impacts
- Urological Disorders and Treatments
- Adrenal and Paraganglionic Tumors
Umeå University
2022
Aarhus University Hospital
2012-2021
Aarhus University
2012-2021
Art Research Centre of the Slovak Academy of Sciences
2018
Orthopaedic Research
2009
First Affiliated Hospital of Zhengzhou University
2009
Université de Montréal
2007
Oslo University Hospital
1974-2005
Intensive Care Foundation
2002
Johns Hopkins University
2002
Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity premature mortality. Based on animal in vitro studies, resveratrol reverts these via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but data human subjects are scarce. The objective this study was to examine the metabolic effects high-dose obese subjects. In a randomized, placebo-controlled, double-blinded, parallel-group design, 24 otherwise healthy men were randomly...
We used functional magnetic resonance imaging (fMRI) to investigate how performing formalized and improvised forms of praying changed the evoked BOLD response in a group Danish Christians. Distinct from secular controls, activated strong temporopolar region, medial prefrontal cortex, temporo-parietal junction precuneus. This finding supports our hypothesis that religious subjects, who consider their God be 'real' capable reciprocating requests, recruit areas social cognition when they pray....
Cerebral water accumulation was studied during induction of brain edema in dystrophin-null transgenic mice ( mdx- β geo ) and control mice. Immunofluorescence immunoelectron microscopic analyses brains revealed a dramatic reduction AQP4 (aquaporin-4) astroglial end-feet surrounding capillaries (blood–brain barrier) at the glia limitans (cerebrospinal fluid–brain interface). The protein is mislocalized, because immunoblotting showed that total abundance unaltered. Brain induced by i.p....
The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, compounds containing choline was studied in vivo by means localized water-suppressed proton magnetic resonance spectroscopy.Eight patients with were serially the phase, 1 week after, 2-4 weeks onset clinical symptoms. Ten healthy volunteers served as controls. A stimulated echo (STEAM) sequence used for measurement brain metabolites a volume interest located within infarcted area visualized...
Phantom breast syndrome (PBS) following mastectomy has already been reported by other authors. The temporal course, character and extent of these phenomena, however, have not yet elucidated. In a prospective study, we investigated the incidence, clinical picture course PBS. One hundred twenty women who, during 1 year period, embarked consecutively on post-operative control or treatment at department, were interviewed standard questionnaire 3 weeks after operation. later 110 patients again....
This study used functional magnetic resonance imaging to investigate how assumptions about speakers' abilities changed the evoked BOLD response in secular and Christian participants who received intercessory prayer. We find that recipients' senders' charismatic have important effects on their executive network. Most notably, deactivated frontal network consisting of medial dorsolateral prefrontal cortex bilaterally speakers they believed had healing abilities. An independent analysis across...
Objective "The obesity epidemic" has led to an increase in obesity-related conditions including non-alcoholic fatty liver disease (NAFLD), for which effective treatments are demand. The polyphenol resveratrol prevents the development of experimental NAFLD through modulation cellular pathways involved calorie restriction. We aimed test hypothesis that alleviates a randomised, clinical trial. Materials and methods A total 28 overweight patients with transaminasemia histological were randomised...
This is the first long-term human clinical trial to report on effects of nicotinamide riboside (NR) skeletal muscle mitochondrial function, content and morphology. NR supplementation decreases phosphoribosyltransferase (NAMPT) protein abundance in muscle. does not affect NAD metabolite concentrations Respiration, distribution quantity mitochondria are unaffected by NR. NAMPT correlates positively with oxidative phosphorylation Complex I, sirtuin 3 succinate dehydrogenase.Preclinical evidence...
Low-grade inflammation is associated with obesity and the metabolic syndrome (MetS). Preclinical evidence suggests that resveratrol (RSV) has beneficial anti-inflammatory effects could have therapeutic implications. To investigate of long-term RSV treatment on MetS. A randomized, placebo-controlled, double-blind, parallel group clinical trial conducted at Aarhus University Hospital. Middle-aged community-dwelling men (N = 74) MetS, 66 whom completed all visits (mean ± standard error mean):...
During fasting, human skeletal muscle depends on lipid oxidation for its energy substrate metabolism. This is associated with the development of insulin resistance and a subsequent reduction insulin-stimulated glucose uptake. The underlying mechanisms controlling action under these conditions are unresolved. In randomized design, we investigated eight healthy subjects after 72-h fast compared 10-h overnight fast. Insulin was assessed by hyperinsulinemic euglycemic clamp determining signaling...
To determine whether long-term course of treated major depression has an effect on the structure brain and hippocampal volume.An 11-year follow-up procedure was used with data collection at baseline again follow-up. Tensor-based morphometry (TBM) automatic volume measure performed different datasets. The dataset consisted T1-weighted magnetic resonance images (MRIs) 24 in-patients suffering from 33 healthy controls. second MRIs 31 remitted depressive patients 36 longitudinal 19 matched...
Introduction: The majority of young women use oral contraceptives (OCs). Use OCs has been associated with lower myofibrillar protein and tendon collagen synthesis rates, but it is unknown whether will limit the adaptive response myotendinous tissue to resistance training. Design Methods: Fourteen healthy untrained regular OC users (24 ± 1 years, fat% 32 1, 35 2 ml⋅min-1⋅kg-1) 14 NOC (non-OC, controls) 2, 34 performed a 10-week supervised extremity progressive training program. Before after...
Background. It is hypothesized from previous positron emission tomography (PET) studies of patients with major depression that dysfunction regions the limbic system and frontal lobes in close connection basal ganglia involved pathophysiology depression. Methods. By means PET 15 O labelled radioactive water we determined an index neuronal activity by mapping cerebral blood flow distribution 42 unselected in-patients suffering moderate to severe 47 healthy controls controlling for age gender....
Using functional magnetic resonance imaging, we contrasted major and minor mode melodies controlled for liking to study the neural basis of musical perception. To examine influence larger dissonance in on activation differences, further introduced a strongly dissonant stimulus, form chromatic scale. Minor were evaluated as sadder than melodies, comparison they caused increased activity limbic structures, namely left parahippocampal gyrus, bilateral ventral anterior cingulate, medial...
A probe for measurement of related values cross-sectional area (CA) and pressure has been developed to record characteristics the walls in luminal organs. The aim this study was test vitro. CA measured range 0.17 7.07 cm2 by means field gradient principle. Pressure 0 20 kPa (150 mmHg) external transducers. After calibration both measuring system did measure parameters adequately. dependent on temperature electrolyte concentration fluid, but not affected size form outside excitation...