A5062019465- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Medical Imaging Techniques and Applications
- Adipose Tissue and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Diet and metabolism studies
- Coronary Interventions and Diagnostics
- Lipid metabolism and disorders
- Cardiac Arrhythmias and Treatments
- Cancer, Hypoxia, and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Shoulder Injury and Treatment
- Neonatal Health and Biochemistry
- Bone health and treatments
- Cardiac electrophysiology and arrhythmias
- TGF-β signaling in diseases
- Elbow and Forearm Trauma Treatment
- Coronary Artery Anomalies
- Cardiac tumors and thrombi
- Vascular anomalies and interventions
- Erythropoietin and Anemia Treatment
Aarhus University Hospital
2011-2025
Aarhus University
2023-2025
Regionshospitalet Viborg
2018
University Hospital of Zurich
2016
Danish National Institute of Public Health
2009
University of Copenhagen
2008
New York Proton Center
2003
Madigan Army Medical Center
1986
[15O]H2O PET/CT allows noninvasive quantification of tissue perfusion and can potentially play a future role in the diagnosis treatment peripheral artery disease. We aimed to evaluate reliability dynamic PET imaging for measuring lower extremity skeletal muscle perfusion. Ten healthy participants underwent same-day test-retest study with six scans legs feet. Manual volume-of-interests were drawn muscles, time activity curves extracted. K1 values (mL/min/100 mL) estimated using single-tissue...
Background The triceps tendon has been described as a single unit with contribution from each of the 3 heads muscle. An observation at time surgical repair injury led to an anatomical study further define anatomy this it inserts on olecranon. Hypothesis medial head that is distinct from, and deep to, common long lateral heads. Study Design Descriptive laboratory case report. Methods Eight cadaveric elbows were dissected examine tendon. None specimens had any evidence prior or surgery elbow....
During fasting, human skeletal muscle depends on lipid oxidation for its energy substrate metabolism. This is associated with the development of insulin resistance and a subsequent reduction insulin-stimulated glucose uptake. The underlying mechanisms controlling action under these conditions are unresolved. In randomized design, we investigated eight healthy subjects after 72-h fast compared 10-h overnight fast. Insulin was assessed by hyperinsulinemic euglycemic clamp determining signaling...
Abstract Context: Cotreatment of acromegaly with pegvisomant and a somatostatin analog (SA) has proven feasible. Previous studies in the field have focused on patients an insufficient response to SA monotherapy whom was added without changing dose. Objective: The objective study whether sufficiently controlled can be transferred combination therapy low-dose reduced Design: Eighteen acromegalic well monotherapy, mean ± se aged 54 3 yr, were randomized parallel over 24 wk unchanged or...
Patients with active acromegaly exhibit insulin resistance despite a lean phenotype whereas controlled disease improves sensitivity and increases fat mass. The mechanisms underlying this paradox remain elusive, but growth hormone (GH)-induced lipolysis plays central role. aim of the study was to investigative molecular dissociated from obesity in patients acromegaly.In prospective study, twenty-one newly diagnosed were studied at diagnosis after control obtained by either surgery alone...
Purpose To determine the value of cardiac hybrid imaging, performed by combining SPECT myocardial perfusion imaging (MPI) with coronary CT angiography, as a long-term predictor for major adverse events (MACEs) (death, infarction [MI], unstable angina requiring hospitalization, revascularization). Materials and Methods For this retrospective single-center study, 428 patients referred between May 2005 December 2008 were classified according to findings into following groups: (a) those stenosis...
BACKGROUND: Myocardial perfusion imaging by positron emission tomography (PET) is recommended as a first-line test in stable patients with chest pain symptoms and selective second-line after an abnormal coronary computed angiography (CTA). It is, however, unknown whether the use of Rubidium-82 ( 82 Rb) versus [ 15 O]H 2 O O-water) affects diagnostic performance artery disease (CAD). The aim this study was to compare Rb-PET O-water-PET head-to-head for diagnosing obstructive CAD. METHODS:...
Pegvisomant is a GH antagonist, which used for the treatment of acromegalic patients. It effectively blocks hepatic and peripheral effects GH, but transient elevations in circulating liver enzymes unknown pathogenesis may occur, seems to be more prevalent when combined with somatostatin analog (SA). Accumulation intrahepatic lipid known cause elevated enzymes, there evidence suggest that impacts content skeletal muscle.Our objective was measure muscle patients before after cotreatment...
Context:Ghrelin is the endogenous agonist for growth hormone secretagogue receptor (GHS-R). Intravenous administration of ghrelin induces insulin resistance and hyperglycemia increases levels free fatty acids (FFA).
Control of disease activity in acromegaly is critical, but the biochemical definitions remain controversial.To compare traditional and novel biomarkers health status patients with treated either surgery alone or somatostatin analog (SA).Sixty-three long-term remission based on normalized total IGF1 levels after (n=36) SA (n=27) were studied a cross-sectional manner. The groups comparable at diagnosis regarding demographic variables. Each subject underwent 3 h serum sampling including 2-h...
To examine the risk of death associated with antiarrhythmic drug (AAD) therapy in a nationwide unselected cohort patients atrial fibrillation (AF).All admitted AF Denmark from 1995 to 2004 and their subsequent use AADs were identified by individual-level linkage registries. Multivariable Cox proportional-hazard models time-dependent covariates used analyse AAD therapy. A total 141,500 included study; these 3356 (2.4%) received treatment flecainide, 3745 (2.6%) propafenone, 23,346 (16.5%)...
Insulin resistance is associated with ectopic lipid deposition. Growth hormone (GH) status also modulates accumulation, but how this associates insulin in patients GH disorders not well established.Twenty-one diagnosed acromegaly and 12 adult deficiency (GHD) were studied at diagnosis after treatment. A reference group of subjects was included. Each study day comprised assessment body composition dual-energy X-ray absorptiometry, deposition the liver by MR spectroscopy, Homeostatic Model...
GH induces acute insulin resistance in skeletal muscle vivo, which rodent models has been attributed to crosstalk between and signaling pathways. Our objective was characterize time course changes pathways for human vivo following exposure the presence absence of an oral glucose load.Eight young men were studied a single-blinded randomized crossover design on 3 occasions: 1) after intravenous bolus 2) plus load (OGTT), 3) saline OGTT. Muscle biopsies taken at t = 0, 30, 60, 120. Blood...
Methods and resultsAll Danish patients were discharged following first-time atrial fibrillation their pharmacotherapy was identified by individual-level-linkage of nationwide registers hospitalization drug dispensing from pharmacies. A total 108 791 survived 30 days after discharge included. In 1995–1996, 7.4% the received beta-blockers, increasing to 44.3% in 2003–2004. The corresponding figures for amiodarone 2.9 5.4%. contrast, use nondihydropyridine calcium-channel blockers, digoxin,...
Treatment with recombinant human erythropoietin (rHuEpo) improves insulin sensitivity in patients end-stage renal disease, and animal studies indicate that Epo increases fat oxidation. However, the metabolic effects of rHuEpo have never been experimentally studied healthy humans. The aim was to investigate an acute bolus on substrate metabolism young men. Ten men were a single-blinded, randomized crossover design 2-wk washout period receiving 400 IU/kg or placebo. Substrate evaluated by...
Objective Fasting and exercise stimulates, whereas glucose suppresses GH secretion, but it is uncertain how these conditions impact signaling in peripheral tissues. To test the original ‘feast famine hypothesis’ by Rabinowitz Zierler, according to which metabolic effects of are predominant during fasting, we specifically hypothesized that fasting act synergy increase STAT-5b target gene expression. Design methods Eight healthy men were studied on two occasions relation a 1 h bout: i) with...
A 75-year-old man with recently diagnosed high-risk prostate cancer was referred for primary staging Ga-prostate-specific membrane antigen (PSMA) PET/CT. The scan revealed intense Ga-PSMA uptake in a lumbar osteophyte on the right side of level L2/L3, whereas several other spinal osteophytes showed no uptake. MRI findings L3 vertebra consistent benign Modic type 1 lesion, but signs malignancy high Ga-PMSA This case presents an as addition to list potential pitfalls be aware when interpreting
To investigate whether pegvisomant treatment in acromegaly induces gradual elevations endogenous serum growth hormone (GH) levels and predict the therapeutic outcome.Seventeen patients (6 women), mean age 46·3 years (range: 23·2-76·2), were studied. For each patient, four hospital visits identified including 'active disease' (no treatment) last follow-up. At visit, 12 blood samples drawn during 3 h an oral glucose tolerance test (OGTT). Eight received a somatostatin analogue addition to on...
Abstract Background Fibroblast growth factor 21 (FGF21) is a circulating hormone with pleiotropic metabolic effects, which inactivated by fibroblast activation protein (FAP). Data regarding interaction between FGF21, FAP, and (GH) are limited, but it noteworthy that collagens also FAP substrates, since GH potently stimulates collagen turnover. Aim To measure FGF21 components, including in patients acromegaly before after disease control. Methods Eighteen active were studied at the time of...
Active acromegaly is characterized by increased lean body mass, but the mechanisms underlying protein anabolic effect are unclear.To study if active induces reversible changes in whole-body and skeletal muscle kinetics.Eighteen patients with were investigated before 47 ± 10 weeks after disease control surgery (n = 8) and/or medical treatment 10). Labeled phenylalanine tyrosine tracers employed to assess regional forearm kinetics. Intramyocellular signaling was assessed biopsies, dual-energy...