A5091745948- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Lung Cancer Research Studies
- Adrenal and Paraganglionic Tumors
- Neuroblastoma Research and Treatments
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Pancreatic and Hepatic Oncology Research
- Sexual Differentiation and Disorders
- Adrenal Hormones and Disorders
- Gastrointestinal disorders and treatments
- Biliary and Gastrointestinal Fistulas
- Hormonal and reproductive studies
- Bladder and Urothelial Cancer Treatments
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Diabetes Treatment and Management
- Trauma and Emergency Care Studies
- Microbial Metabolites in Food Biotechnology
- Gestational Trophoblastic Disease Studies
- Esophageal Cancer Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Testicular diseases and treatments
Copenhagen University Hospital
1968-2025
Rigshospitalet
1972-2025
University of Copenhagen
2014-2025
Linköping University
2017-2024
Novo Nordisk (United Kingdom)
2024
Novartis (Switzerland)
2024
Capital Region of Denmark
2018
Vestre Viken Hospital Trust
2016
Herlev Hospital
2005-2015
Technical University of Denmark
2006-2008
IGF1 is believed to influence ageing and development of cardiovascular disease (CVD) through complex mechanisms. Reduced levels might be causally associated with conditions accompanying including CVD. However, in animal models reduced GH-IGF1 signalling increases lifespan. activity also longevity humans.The objective was investigate if plasma were all cause mortality, the chronic heart failure (CHF) a major CV event.A population based study 642 individuals, aged 50-89 years. Development CHF...
A proportion of patients with primary aldosteronism (PA) have a paradox increasein plasma-Aldosterone (P-Aldosterone) concentration (PAC) during the Captopril Challenge Test (CCT). This study aimed to investigate if paradoxical rise in PAC CCT, was associated clinical characteristics or outcomes inpatients PA. We hypothesized that response CCT is ameasure disease severity, reflected by higher baseline aldosterone/renin-ratio (ARR). retrospective PA,confirmed who were referred for adrenal...
Objective To study the time-dependent changes in disease features of Danish patients with acromegaly, including treatment modalities, biochemical outcome, and comorbidities, a particular focus on cancer mortality. Methods Pertinent acromegaly-related variables were collected from 739 diagnosed since 1990. Data are presented across three decades (1990–1999, 2000–2009, 2010–2021) based year diagnosis or initiation. Results Adenoma size insulin-like growth factor I (IGF-I) levels at did not...
Urothelial carcinoma of the urinary bladder (UCB) is 4th most common cancer type in men developed countries, and tumor recurrence or progression occurs more than half patients. Previous studies report contradictory trends incidence survival over past decades. This article describes UCB from 1981 to 2014, including both invasive non-invasive using data Cancer Registry Norway. In Norway, 33,761 patients were diagnosed with between 2014. Incidence 5-year relative calculated, stratified by sex,...
Abstract Introduction Diagnosis and pathological classification of insulinomas are challenging. Aim To characterize localization tumors, surgery outcomes, histopathology in patients with insulinoma. Methods Patients surgically resected sporadic insulinoma were included. Results Eighty Seven had a malignant tumor. A total 312 diagnostic examinations performed: endoscopic ultrasonography (EUS; n = 59; sensitivity, 70%), MRI (n 33; 58%), CT 55; 47%), transabdominal (US; 45; 40%), somatostatin...
The present report describes the history of a 58-year-old woman with rapidly progressing neuroendocrine pancreatic tumor (initially G2) presenting extensive liver, bone, and lymph node metastases. Previous treatments included chemotherapy, hemithyroidectomy for right lobe metastasis, Peptide Receptor Radionuclide Therapy (PRRT) [177Lu]Lu-DOTATATE, Lanreotide, Everolimus, liver embolization. Due to severe disease progression, after biopsy revealing grade G3, PRRT somatostatin receptor...
The GH/IGF1 axis may modulate inflammatory processes. However, the relationship seems complicated as both pro- and anti-inflammatory effects have been demonstrated.Twelve healthy volunteers (mean age 36, range 27-49 years) were treated in random order with increasing doses of GH for 3 weeks (first week 0.01 mg/kg per day, second 0.02 third 0.03 day) or a receptor antagonist (pegvisomant; first 10 mg/day last two 15 mg/day), separated by 8 washout. Circulating levels pro-inflammatory...
Abstract Objective Mitotane is used in the treatment of adrenocortical carcinoma (ACC). Metabolic and hormonal side effects mitotane, effect subsequent with statins hormones discontinuation mitotane were assessed. Patients methods Fifty patients included. Lipid profiles, thyroid hormones, sex adrenal function from first year after cessation evaluated. Results After 6 months total cholesterol increased (median) 5.1 (IQR 4.3 to 5.8) 7.4 (6.2–9.0) mmol/L, p < .001. LDL, HDL triglyceride also...
Background: Small intestinal neuroendocrine tumors (siNET) are one of the most common neoplasms. Radical surgery is only curative treatment. Method: We utilized a single-center study including consecutive patients diagnosed from 2000 to 2020 and followed them until death or end study. Disease-specific survival recurrence-free (RFS) were investigated by Cox regression analyses with inclusion prognostic factors. Aims/primary outcomes: identified three groups: (1) disease specific-survival in...
Background: Given the rarity and heterogeneity of pancreatic neuroendocrine neoplasms (pNEN), treatment algorithms sequencing are primarily guided by expert opinions with limited evidence. Aim: To investigate overall survival (OS), median progression-free (mPFS), prognostic factors associated most common medical treatments for pNEN. Methods: Retrospective single-center study encompassing patients diagnosed monitored between 2000 2020 (n = 192). Results: Median OS was 36 (95% CI: 26–46)...
Introduction: Pheochromocytomas and paragangliomas are rare neuroendocrine tumours that originate from chromaffin cells within the adrenal medulla or extra-adrenal sympathetic ganglia. Management of disseminated metastatic pheochromocytomas continues to pose challenges relies on limited evidence. Method: In this study, we report retrospective data median overall survival (OS) progression-free (PFS) for all Danish patients treated with peptide receptor radionuclide therapy (PRRT)...
Abstract Purpose Patients with tumors involving the hypothalamic region are at high risk of developing morbid obesity due to disturbances in appetite regulative nuclei hypothalamus. We evaluated effect Glucagon-like peptide 1 (GLP-1) analogue semaglutide patients obesity. Methods recorded weight changes from real-time data before and after treatment our outpatient clinic Department Endocrinology Rigshospitalet, September 2020 November 2023. Results A total 26 were included this study (15...
Summary Growth hormone ( GH ) and insulin‐like growth factor I IGF ‐I) receptors are present on pituitary gonadotrophs testicular Leydig Sertoli cells. Thus, the / ‐I system may modulate pituitary‐gonadal axis in males. This is a randomized cross‐over study. Eight healthy male volunteers (mean age 35, range 29–46 years) were treated with for 3 weeks (1st week 0.01, 2nd 0.02, 3rd 0.03 mg/day/kg) or receptor antagonist (Pegvisomant) 10, last 2 15 mg/day), separated by 8 of washout. Before...
The incidence of small intestinal (SI) and pancreatic neuroendocrine tumors (siNETs pNETs) seems to have increased. increased frequency incidental findings might be a possible explanation. study aimed examine (1) changes in the stage at diagnosis (2010-2011 vs. 2019-2020), (2) initial indication for diagnostic workup 3) differences between incidentally discovered symptomatic disease during entire period.We performed retrospective study, that includes consecutive siNET pNET patients referred...
A report is given on four non-cirrhotic patients in whom the hepatic artery proper was ligated for different reasons. In post-operative course only slight signs of liver damage were present and no later sequels observed.