A5064370335- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Vitamin D Research Studies
- Genetic Associations and Epidemiology
- Multiple Sclerosis Research Studies
- Cancer Immunotherapy and Biomarkers
- Pharmacovigilance and Adverse Drug Reactions
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Prostate Cancer Treatment and Research
- Genetic Syndromes and Imprinting
- Nutritional Studies and Diet
- Pharmacogenetics and Drug Metabolism
- CAR-T cell therapy research
- Statistical Methods in Clinical Trials
- Cancer, Stress, Anesthesia, and Immune Response
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Cutaneous Melanoma Detection and Management
- Inflammatory Bowel Disease
- Melanoma and MAPK Pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Norwegian Institute of Public Health
2015-2025
Cancer Registry of Norway
2016-2025
Posten (Norway)
2023
Metropolitan University
2021
University of Oslo
2009-2018
Oslo University Hospital
2009-2018
Diakonhjemmet Hospital
2018
Akershus University Hospital
2015
Chungbuk National University
2015
Objective Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients. Methods Whole blood, CD4+ and CD8+ T cell 16 female, treatment naïve patients 14 matched controls was profiled using the HumanMethylation450K BeadChip. Genotype data were used to assess genetic homogeneity of our sample exclude potential SNP-induced measurement errors. Results As expected, significant differences between cells, observed,...
Epigenome-wide association studies of prenatal exposure to different environmental factors are becoming increasingly common. These usually performed in umbilical cord blood. Since blood comprises multiple cell types with specific DNA methylation patterns, confounding caused by cellular heterogeneity is a major concern. This can be adjusted for using reference data consisting signatures isolated from However, the most commonly used set based on samples adult males and not representative type...
Coronary artery disease (CAD) is a critical determinant of morbidity and mortality. Previous studies have identified several cardiovascular risk factors, which may partly arise from shared genetic basis with CAD, thus be useful for discovery CAD genes.We aimed to improve genes inform the pathogenic relationship between factors using polygenic signal-informed statistical framework.Using genome-wide association summary statistics pleiotropy-informed conditional conjunctional false rate...
Immunological hallmarks of multiple sclerosis include the production antibodies in central nervous system, expressed as presence oligoclonal bands and/or an increased immunoglobulin G index—the level cerebrospinal fluid compared to serum. However, underlying differences between band-positive and -negative patients with reasons for variability index are not known. To identify genetic factors influencing variation antibody levels sclerosis, we have performed a genome-wide association screen...
AimMortality among patients with bladder cancer is usually reported to be higher for women than men, but how the risk differs and why remain largely unexplained. We also described gender-specific differences in survival estimated what extent they can explained by T-stage distribution at first diagnosis.MethodsThe present study comprised all 15,129 new cases of histologically verified invasive non-invasive urothelial carcinoma urinary diagnosed between 1997 2011 as registered Cancer Registry...
Genome-wide association (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT). A GWA study TGCT was performed by genotyping 610 240 single-nucleotide polymorphisms (SNPs) in 1326 cases and 6687 controls from Sweden Norway. No novel genome-wide significant associations were observed this discovery stage. We put forward 27 SNPs 15 regions 12 previously reported, replication 710 case-parent triads 289 290 controls. Predefined biological pathways...
Occupational exposures constitute the second leading cause of urinary bladder cancer after tobacco smoking. Increased risks have been found in petroleum industry, but high-quality exposure data are needed to explain these observations.Using a prospective case-cohort design, we analysed 189 cases (1999-2017) and 2065 randomly drawn non-cases from Norwegian Offshore Petroleum Workers cohort. Cases were identified Cancer Registry Norway, while work histories (1965-1998) lifestyle factors...
The presence of oligoclonal bands (OCB) in cerebrospinal fluid (CSF) is a typical finding multiple sclerosis (MS). We applied data from Norwegian, Swedish and Danish (i.e. Scandinavian) MS patients genome-wide association study (GWAS) to search for genetic differences relating OCB status. GWAS was compared 1367 positive 161 negative Scandinavian patients, nine the most associated SNPs were genotyped replication 3403 patients. HLA-DRB1 genotypes analyzed subset (n = 2781) 292) 890 healthy...
There is considerable evidence that many complex traits have a partially shared genetic basis, termed pleiotropy. It therefore useful to consider integrating genome-wide association study (GWAS) data across several traits, usually at the summary statistic level. A major practical challenge arises when these GWAS overlapping subjects. This particularly an issue estimating pleiotropy using methods condition significance of one trait on signficance second, such as covariate-modulated false...
Vessel invasion (VI) in transurethral resection of bladder tumor (TURBT) usually assessed without immunohistochemistry (IHC) is associated with nodal metastases and reduced survival. Separation blood (BVI) lymph (LVI) vessel by IHC cystectomy (RC) suggests different prognostic trajectories could guide management after TURBT. However, prevalence BVI LVI TURBT accuracy between RC has not been thoroughly evaluated. We aimed to examine the VI, using IHC, investigate their agreement across...
Abstract Innate differences in the female and male immune systems subgroup results from clinical trials have led researchers to hypothesize there could be sex‐based disparities effectiveness of checkpoint inhibitors for anticancer treatment. This real‐world study evaluated potential survival among non‐small cell lung cancer (NSCLC) patients treated with pembrolizumab as monotherapy or combination chemotherapy. The population‐based cohort included 1586 females 1978 males diagnosed advanced...
Urothelial carcinoma of the urinary bladder (UCB) is 4th most common cancer type in men developed countries, and tumor recurrence or progression occurs more than half patients. Previous studies report contradictory trends incidence survival over past decades. This article describes UCB from 1981 to 2014, including both invasive non-invasive using data Cancer Registry Norway. In Norway, 33,761 patients were diagnosed with between 2014. Incidence 5-year relative calculated, stratified by sex,...
Objective to explore the association between genetic markers and Oligoclonal Bands (OCB) in Cerebro Spinal Fluid (CSF) of Italian Multiple Sclerosis patients. Methods We genotyped 1115 patients for HLA-DRB1*15 HLA-A*02. In a subset 925 we tested with 52 non-HLA SNPs associated MS susceptibility calculated weighted Genetic Risk Score. Finally, performed Genome Wide Association Study (GWAS) OCB status on 562 The best GWAS were replicated silico Scandinavian Belgian populations, meta-analyzed....
Aim: We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its with BMI adolescents. Materials & methods: Differential analyses of 3.1 million CpG sites were saliva samples from 50 lean heavy adolescent girls by genome-wide targeted bisulfite-sequencing. Results: identified 100 p-values < 0.000524, seven regions 'bumphunting' five islands that differed significantly between two groups. The ten most strongly...
Background: Differences in DNA methylation have been reported B and T lymphocyte populations, including CD4+ cells, isolated from rheumatoid arthritis (RA) patients when compared to healthy controls. cells are a heterogeneous cell type with subpopulations displaying distinct patterns. In this study, we investigated using reduced representation bisulfite sequencing two populations (CD4+ memory naïve cells) three groups: newly diagnosed, disease modifying antirheumatic drugs (DMARD) RA (N =...
Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction hormone producing cells adrenal cortex. The underlying molecular mechanisms are largely unknown, but it commonly accepted that a combination genetic susceptibility environmental impact critical. In present study, we identified multiple hypomethylated gene promoter regions in patients with isolated AAD using DNA CD4+ T cells. differentially...
Several studies have reported age-associated changes in DNA methylation the first few years of life and adult populations, but extent such during childhood is less well studied. The goals this study were to investigate what degree intra-individual are associated with aging dissect directly from effect mediated through variation cell-type composition (CTC). We performed reduced representation bisulfite sequencing (RRBS) peripheral whole-blood samples collected at 2, 10, 16 age. identified...
Previous studies assessed the prognostic effect of aspirin, statins, and metformin in breast cancer (BC) patients, with inconclusive results.We performed a nationwide population-based cohort study to evaluate if post-diagnostic use low-dose was associated BC-specific survival. Women aged ≥ 50 years diagnosed BC 2004-2017, who survived 12 months after diagnosis (follow-up started diagnosis), were identified Cancer Registry Norway. The Norwegian Prescription Database provided information on...
Melanoma is the cancer with most rapidly rising incidence rate in Norway. Although exposure to ultraviolet radiation (UVR) major environmental risk factor, other factors may also contribute. Antidepressants have inhibiting and promoting side effects, their prescription rates increased parallel melanoma incidence. Thus, we aimed prospectively examine association between use of antidepressants by using nation-wide data from Cancer Registry Norway, National Registry, Norwegian Prescription...