A5016344737- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- Central Venous Catheters and Hemodialysis
- Dialysis and Renal Disease Management
- Vascular Procedures and Complications
- Pediatric Urology and Nephrology Studies
- Atomic and Subatomic Physics Research
- Renal function and acid-base balance
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Hemodynamic Monitoring and Therapy
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Vascular anomalies and interventions
- Vascular Malformations Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Breastfeeding Practices and Influences
- Acute Kidney Injury Research
- Thermal Regulation in Medicine
- NMR spectroscopy and applications
- HIV/AIDS drug development and treatment
- Eosinophilic Disorders and Syndromes
- Global Public Health Policies and Epidemiology
- Artificial Intelligence in Healthcare
University of Washington
2025
University of Nottingham
2016-2024
VA Salt Lake City Healthcare System
2022
University of Utah
2022
Case Western Reserve University
2019
Cleveland Clinic Lerner College of Medicine
2019
The Medical Center of Aurora
2019
Mansfield University
2016-2017
Royal Derby Hospital
2016
Queen Elizabeth Hospital
2009
Hemodynamic stress during hemodialysis (HD) results in recurrent segmental ischemic injury (myocardial stunning) that drives cumulative cardiac damage. We performed a fully comprehensive study of the cardiovascular effect dialysis sessions using intradialytic magnetic resonance imaging (MRI) to examine comparative acute effects standard HD versus hemodiafiltration (HDF) stable patients. randomly allocated 12 patients on (ages 32–72 years old) either or HDF. Patients were stabilized modality...
Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow perfusion), oxygenation (BOLD T2*), microstructure (diffusion, T1 mapping). Methods: We use our provide (1) comprehensive set parameters [renal vein flow, perfusion, T1, T2*, diffusion (ADC, D, D*, fp), total kidney volume] in large cohort healthy participants (127 with mean age 41 ± 19 years) show the MR field strength (1.5 T...
ObjectiveEarly thrombosis (ET) contributes to autogenous arteriovenous fistula (AVF) failure. We studied patients undergoing AVF placement in the Hemodialysis Fistula Maturation Study, a prospective, observational cohort study, using nested case-control analysis identify preoperative and intraoperative predictors of ET.MethodsET cases were compared with controls, who matched for gender, age, diabetes, dialysis status, surgeon volume. ET was defined as diagnosed by physical examination or...
Abstract Objectives This study aimed at developing technical recommendations for the acquisition, processing and analysis of renal ASL data in human kidney 1.5 T 3 field strengths that can promote standardization perfusion measurements facilitate comparability results across scanners multi-centre clinical studies. Methods An international panel 23 experts followed a modified Delphi process, including on-line surveys two in-person meetings, to formulate series consensus statements regarding...
Abstract To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) transverse (T2) relaxation time mapping. A multidisciplinary panel consisting 18 experts in field T1 T2 mapping participated a consensus project, which was initiated by European Cooperation Science Technology Action PARENCHIMA CA16103. Consensus were formulated using two-step modified Delphi method. The first survey consisted 56 items mapping, 4 reached pre-defined threshold 75% or...
Abstract Background Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated in chronic kidney disease (CKD). Methods We performed multi-parametric renal persons with CKD (n = 22, 61 ± 24 years) who had biopsy measured glomerular filtration rate (mGFR), matched healthy volunteers (HV) 25 years). Longitudinal...
Abstract Purpose The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on MRI. Methods A task force was formed in July 2018 focused five methods. draft attaining distributed publicly consultation finalised at an open meeting (Prague, October 2018). Four expert panels completed surveys between March 2019, discussed...
Purpose Total kidney volume (TKV) is an important measure in renal disease detection and monitoring. We developed a fully automated method to segment the kidneys from T 2 ‐weighted MRI calculate TKV of healthy control (HC) chronic (CKD) patients. Methods This uses machine learning, specifically 2D convolutional neural network (CNN), accurately left right data. The data set consisted 30 HC subjects CKD model was trained on 50 manually defined segmentations. subsequently evaluated test sets,...
Abstract The pathogenesis of arteriovenous fistula (AVF) maturation failure is unclear. We evaluated the associations wall shear stress (WSS) with subsequent AVF remodeling and clinical using regression models in this prospective cohort study. Participants underwent duplex ultrasound at postoperative Day 1, Week 2, 6 to measure blood flow rate diameter draining vein proximal artery. median WSS 602 participants decreased from 1 (from 33.4 21.6 dyne/cm 2 ) but did not change noticeably for...
Abstract Purpose To create an inventory of image processing pipelines arterial spin labeling (ASL) and list their main features, to evaluate the capability, flexibility, ease use publicly available guide novice ASL users in selecting optimal pipeline. Methods Developers self‐assessed using a questionnaire developed by Task Force 1.1 ISMRM Open Science Initiative for Perfusion Imaging. Additionally, each pipeline was evaluated two independent testers with basic experience scoring system...
A retrospective review was conducted to determine the safety and efficacy of ezetimibe as a treatment option for renal transplant recipients. We evaluated medical records 34 adult recipients receiving monotherapy or combination therapy. Fasting lipid profiles were obtained at baseline 1-6 months post-ezetimibe initiation. Twenty patients received cyclosporine, 12 tacrolimus, 1 patient either sirolimus no calcineurin therapy time Monotherapy started in 8 patients, who had all previously...
Noninvasive methods of magnetic resonance imaging (MRI) can quantify parameters kidney function. The main purpose this study was to determine baseline values such in healthy volunteers. In 28 volunteers (15 women and 13 men), arterial spin labeling estimate regional renal perfusion, blood oxygen level-dependent transverse relaxation rate (R2*) oxygenation, apparent diffusion coefficient (ADC), true (D), longitudinal time (T1) tissue properties were determined bilaterally the cortex outer...
Circadian regulation of kidney function is involved in maintaining whole body homeostasis, and dysfunctional circadian rhythm can potentially be disease development. Magnetic resonance imaging (MRI) provides reliable reproducible repetitive estimates noninvasively without the risk adverse events associated with contrast agents ionizing radiation. The purpose this study was to estimate variations healthy human subjects MRI relate findings urinary excretions electrolytes markers function....
A number of imaging readout schemes are proposed for renal arterial spin labeling (ASL) to quantify kidney cortex perfusion, including gradient echo-based methods balanced fast field echo (bFFE) and gradient-echo echo-planar (GE-EPI), or spin-echo (SE-EPI) turbo (TSE). Here, we compare these two-dimensional (2D) evaluate the optimal scheme pulsed ASL (PASL) assessment human perfusion at 3 T. Ten healthy volunteers with normal function were scanned using each 2D multi-slice scheme, in...
Acute kidney injury (AKI) is associated with a marked increase in mortality as well subsequent chronic disease (CKD) and end-stage disease. We performed multiparametric magnetic resonance imaging (MRI) the aim of identifying potential non-invasive MRI markers renal pathophysiology AKI during recovery.Nine participants underwent inpatient scans at time AKI; seven had follow-up 3 months 1 year following AKI. Multiparametric assessed total volume (TKV), perfusion using arterial spin labelling,...
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The aim of this study is to evaluate an intervention using social marketing principles increase breastfeeding and reduce smoking during pregnancy in a population improve life chances for children born town north east England.Breastfeeding cessation attendance rates were measured against targets set government-local health authority agreement.Targets bettered both cessation.This marketing-based approach successful.
Background & aimsBlood volume expanding properties of colloids are superior to crystalloids. In addition oncotic/osmotic properties, the electrolyte composition infusions may have important effects on visceral perfusion, with containing supraphysiological chloride causing hyperchloremic acidosis and decreased renal blood flow. this non-inferiority study, a validated healthy human subject model was used compare colloid (4% succinylated gelatin) crystalloid fluid regimens volume, function,...
Endotoxemia is common in advanced chronic kidney disease and particularly severe those receiving dialysis. In hemodialysis patients, translocation from the bowel occurs as a consequence of recurrent circulatory stress leading to reduction circulating splanchnic volume increased intestinal permeability. Peritoneal dialysis (PD) patients are often expanded have continuous direct immersion fluid; these may also be important factors endotoxin would suggest different therapeutic strategies...
Standardisation and multicentre evaluation of renal MRI measures is crucial for clinical translation. Here we present results a Travelling kidney study on GE, Philips Siemens using harmonised multiparametric protocol, show B 0 1 mapping, T , 2 * mapping. The mode within the kidneys did not vary across vendors, however FWHM was narrower Vendor 1. No significant differences were seen in MOLLI values cortex medulla after this data corrected offset NIST phantom.
DICOM is the universally recognized standard for medical imaging, but reading and writing from databases remains a challenging task most data scientists. The dbdicom package was developed to provide an intuitive programming interface entire databases, replaces confusing DICOM-native concepts by language notations that will be more familiar scientists working in python. available under open license early stages of development currently rolled out 3 multi-vendor, multi-center studies.