A5031047046- Advanced MRI Techniques and Applications
- Renal and Vascular Pathologies
- MRI in cancer diagnosis
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Nephrotoxicity and Medicinal Plants
- Fetal and Pediatric Neurological Disorders
- Cardiac Imaging and Diagnostics
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Renal cell carcinoma treatment
- Transplantation: Methods and Outcomes
- Pancreatic function and diabetes
- Hormonal Regulation and Hypertension
- Cardiovascular Health and Disease Prevention
- Potassium and Related Disorders
- Diabetes Management and Research
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Neurological and metabolic disorders
- Vitamin K Research Studies
- Cardiovascular Function and Risk Factors
- Vascular anomalies and interventions
University of Glasgow
2015-2024
Queen Elizabeth University Hospital
2017-2024
NHS Greater Glasgow and Clyde
2020-2023
Forth Valley Royal Hospital
2020
Western Infirmary
2012-2014
British Heart Foundation
2014
Stobhill Hospital
2011
University of North Carolina at Chapel Hill
2007
Abstract To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) transverse (T2) relaxation time mapping. A multidisciplinary panel consisting 18 experts in field T1 T2 mapping participated a consensus project, which was initiated by European Cooperation Science Technology Action PARENCHIMA CA16103. Consensus were formulated using two-step modified Delphi method. The first survey consisted 56 items mapping, 4 reached pre-defined threshold 75% or...
Arterial spin labelling (ASL) MRI measures perfusion without administration of contrast agent. While ASL has been validated in animals and healthy volunteers (HVs), application to chronic kidney disease (CKD) limited. We investigated the utility patients with CKD.We studied renal 24 HVs 17 CKD (age 22-77 years, 40% male) using at 3.0T. Kidney function was determined estimated glomerular filtration rate (eGFR). T1 relaxation time measured modified look-locker inversion xFB02;ow-sensitive...
Measurement of renal perfusion is a crucial part measuring kidney function. Arterial spin labelling magnetic resonance imaging (ASL MRI) non-invasive method using magnetised blood as endogenous contrast. We studied the reproducibility ASL MRI in normal volunteers. was performed healthy volunteers on 2 occasions 3.0 Tesla scanner with flow-sensitive alternating inversion recovery (FAIR) preparation steady state free precession (True-FISP) pulse sequence. Kidney volume measured from scanned...
Premature cardiovascular disease and death with a functioning graft are leading causes of loss, respectively, in kidney transplant recipients (KTRs). Vascular stiffness calcification markers that prevalent KTR associated subclinical vitamin K deficiency. We performed single-center, phase II, parallel-group, randomized, double-blind, placebo-controlled trial (ISRCTN22012044) to test whether supplementation reduced vascular (MRI-based aortic distensibility) or (coronary artery calcium score on...
Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) post-COVID-19 patients, and patient reported health outcomes following COVID-19 infection.This prospective study investigated time-course of multiorgan injury survivors during convalescence.Clinical information, blood biomarkers, outcome measures were prospectively acquired at enrolment...
Premature cardiovascular disease in patients with chronic kidney (CKD) is not explained by traditional risk factors and oxidative stress may contribute via endothelial vascular dysfunction. We investigated the effect of ascorbic acid on function CKD compared controls hypertension (HTN). A crossover study intravenous saline was conducted. Biomarkers were measured, while pulse wave analysis brachial flow-mediated dilatation performed to assess large artery function. Twenty HTN 30 Stages 3–5...
Proton pump inhibitors (PPIs) are associated with acute tubulointerstitial nephritis and there reports associating their use the development of chronic kidney disease (CKD).To determine if PPI is major adverse renal events (MARE) in patients CKD.Observational cohort study comprising CKD attending secondary care clinics from 1 January 2006 until 31 December 2016.We collated baseline clinical, socio-demographic biochemical data at start (PPI group) or inception (control group). MARE was...
Premature cardiovascular (CV) death is the commonest cause of in renal transplant recipients. Abnormalities left ventricular (LV) structure (collectively termed uremic cardiomyopathy) and atrial (LA) dilation, a marker fluid status diastolic function, are risk factors for reduced survival patients with end stage disease (ESRD). In present analysis, we studied impact pre-transplant LA LV abnormalities on after successful transplantation (RT).One hundred nineteen recipients (first transplant,...
Abstract Recent World Health Organization guidance has aimed to provide pragmatic acknowledging the role of sequential nasopharyngeal swabs taken >24 hours apart for SARS‐CoV‐2 in high‐risk populations. Patients with chronic kidney disease (CKD) are known have an altered immune milieu which may be associated a delay viral clearance. Here, cross‐sectional observational study 138 patients admitted infection at two large regional hospitals Scotland, UK examined median time consecutive...
Abstract Objective To assess interobserver reproducibility of different regions interest (ROIs) on multi-parametric renal MRI using commercially available software. Materials and methods Healthy volunteers (HV), patients with heart failure (HF) transplant recipients (Tx) were recruited. Localiser scans, T1 mapping pseudo-continuous arterial spin labelling (pCASL) performed. HV Tx also underwent diffusion-weighted imaging to allow calculation apparent diffusion coefficient (ADC). For T1,...
Mapping of left ventricular (LV) native T1 is a promising non-invasive, non-contrast imaging biomarker. Native myocardial times are prolonged in patients requiring dialysis, but there concerns that the dialysis process and fluctuating fluid status may confound results this population. We aimed to assess changes cardiac parameters on 3T cardiovascular magnetic resonance (CMR) before after haemodialysis, with specific focus mapping. This single centre, prospective observational study which...
Body mass index (BMI) is associated with renal disease progression in unspecified CKD. The relationship between BMI and primary glomerular (GN) may be more complex. We aimed to evaluate the association patients (GN). This was a single-centre retrospective cohort study performed adult biopsy-proven GN (excluding minimal change disease) from January 2000 December 2015, follow-up data until June 2017. at time of biopsy categorised as ≤25 kg/m2, > 25 ≤30 kg/m2 30 kg/m2. used univariate...
Premature sudden cardiovascular death is the commonest cause of in end-stage renal disease (ESRD) patients and associated with uraemic cardiomyopathy [left ventricular hypertrophy (LVH), systolic dysfunction (LVSD) or LV dilation]. High-energy phosphates (HEP), quantified using phosphorus-31 magnetic resonance spectroscopy, are reduced diabetes, heart failure uraemia. Phosphocreatine:β adenosine triphosphate (PCr:ATP) ratio an index metabolic activity. We compared resting HEPs ESRD...
Aims The clinical significance of common histological parameters in acute interstitial nephritis (AIN) is uncertain. We aimed to evaluate the utility histology predicting outcomes patients with AIN. Methods and results Adult renal biopsies yielding a diagnosis AIN between 2000 2015 were re‐examined. Patients divided into groups based on: (i) percentage non‐fibrotic cortex containing inflammation (NFI score) (NFI‐1 = 0–24%; NFI‐2 25–74%; NFI‐3 75–100%) (ii) tubular atrophy (TA (TA1 0–9%; TA2...
Patients with end-stage kidney disease (ESKD) are at increased risk of premature death, cardiovascular being the predominant cause death. We hypothesized that left ventricular global longitudinal strain (LV-GLS) measured by feature-tracking magnetic resonance imaging (CMRI) would be associated all-cause mortality in patients ESKD.A pooled analysis CMRI studies ESKD acquired within a single centre between 2002 and 2016 was carried out. CMR parameters including LV ejection fraction (LVEF),...
Injecting drug users are prone to atypical infections. We present a case of septic thrombophlebitis secondary Fusobacterium gonidiaformans infection in heroin user, which demonstrates the frequently unusual nature pathogens and presentations this group patients.
Sodium zirconium cyclosilicate (SZC) reduces serum potassium in patients with chronic hyperkalaemia clinical trials, but its role the emergency treatment of is unproven. We hypothesized that SZC use for emergent would be associated a reduction rates interventions hyperkalaemia.