A5057086305- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Renal and Vascular Pathologies
- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Fetal and Pediatric Neurological Disorders
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Mesenchymal stem cell research
- Ultrasound and Hyperthermia Applications
- Traumatic Brain Injury Research
- Cancer Cells and Metastasis
- Neurological Disease Mechanisms and Treatments
- Bone and Joint Diseases
- Cancer-related cognitive impairment studies
- Cellular Mechanics and Interactions
- Neurogenesis and neuroplasticity mechanisms
- Lung Cancer Research Studies
- Lymphatic System and Diseases
- Trauma and Emergency Care Studies
- Obsessive-Compulsive Spectrum Disorders
- Sleep and Work-Related Fatigue
Ghent University
2019-2024
Ghent University Hospital
2018-2024
University of Antwerp
2015-2023
Antwerp University Hospital
2015-2023
University of Cincinnati
2018
Foundation of Cardiac Surgery Development
2018
Vrije Universiteit Brussel
2017
Maastricht University
2008-2015
Brain Innovation (Netherlands)
2010-2015
Icometrix (Belgium)
2015
Abstract The blood oxygen level dependent (BOLD) response, as measured with fMRI, offers good spatial resolution compared to other non‐invasive neuroimaging methods. use of a spin echo technique rather than the conventional gradient may further improve by refocusing static dephasing effects around larger vessels, so sensitizing signal microvasculature. In this work width point spread function (PSF) BOLD response at field strength 3 Tesla is for these two approaches. A double EPI pulse...
Abstract To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) transverse (T2) relaxation time mapping. A multidisciplinary panel consisting 18 experts in field T1 T2 mapping participated a consensus project, which was initiated by European Cooperation Science Technology Action PARENCHIMA CA16103. Consensus were formulated using two-step modified Delphi method. The first survey consisted 56 items mapping, 4 reached pre-defined threshold 75% or...
Abstract Purpose The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on MRI. Methods A task force was formed in July 2018 focused five methods. draft attaining distributed publicly consultation finalised at an open meeting (Prague, October 2018). Four expert panels completed surveys between March 2019, discussed...
To quantitatively validate diffusion-weighted MRI (DW-MRI) applications, a hardware phantom containing crossing fibers at sub-voxel level is presented. It suitable for validation of large spectrum DW-MRI applications from acquisition to fiber tracking, which an important recurrent issue in the field.Phantom properties were optimized resemble human white matter terms anisotropy, fractional and T(2). Sub-voxel crossings constructed angles 30, 50, 65 degrees, by wrapping polyester fibers, with...
Abstract Background Reducing radiation dose to the hippocampus with hippocampal avoidance prophylactic cranial irradiation (HA-PCI) is proposed prevent cognitive decline. It has, however, not been investigated whether atrophy actually mitigated by this approach. Here, we determined HA-PCI reduces atrophy. Additionally, evaluated neurotoxicity of (HA-)PCI other brain regions. Finally, associations and memory Methods High-quality research MRI scans were acquired in multicenter, randomized...
Observer variability in local radiological reading is a major concern large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of study compare with TBI imaging datasets and investigate the added value review. total 2050 admission computed tomography (CT) scans from subjects enrolled Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) were analyzed for seven main...
A great need exists in traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (aSAH) for objective biomarkers to better characterize the disease process serve as early endpoints clinical studies. Diffusion tensor imaging (DTI) has shown promise TBI, but much less is known about aSAH.To explore use of whole-brain DTI tractography TBI aSAH a biomarker endpoint.Of cohort 43 patients with severe (n = 20) or 23) enrolled prospective, observational, multimodality monitoring study,...
Purpose Diffusion kurtosis imaging (DKI) is an advanced magnetic resonance modality that known to be sensitive changes in the underlying microstructure of brain. Image voxels diffusion weighted images, however, are typically relatively large making them susceptible partial volume effects, especially when part voxel contains cerebrospinal fluid. In this work, we introduce “Diffusion Kurtosis Imaging with Free Water Elimination” (DKI‐FWE) model separates signal contributions free water and...
Purpose A great need exists for objective biomarkers to assess graft healing following ACL reconstruction guide the time of return sports. The purpose this study was evaluate feasibility and reliability diffusion tensor imaging (DTI) delineate anterior cruciate ligament (ACL) investigate its properties using a clinical 3T scanner. Materials Methods DTI knee (b = 0, 400, 800 s/mm 2 , 10 directions, repeated 16 times total 336 diffusion‐weighted volumes) performed at in 17 patients between 3 7...
Abstract Background Elevated tumor tissue interstitial fluid pressure (IFP) is an adverse biomechanical biomarker that predicts poor therapy response and aggressive phenotype. Advances in functional imaging have opened the prospect of measuring IFP non‐invasively. Image‐based estimation requires knowledge hydraulic conductivity ( K ), a measure for ease bulk flow through interstitium. However, data on magnitude human cancer are not available. Methods We measured using modified Ussing...
In the field of experimental stem cell therapy, intra-arterial (IA) delivery yields best results concerning, for example, migrated number at targeted site. However, IA application also appears to be associated with increased mortality rates and infarction. Since many rodent studies systemically apply 1 × 106 cells, this could a consequence engrafted number. The aim study was therefore investigate effect different doses adipose tissue-derived cells (ASCs) on engraftment stroke outcome...
Purpose Since Diffusion Weighted Imaging ( DWI ) data acquisition and processing are not standardized, substantial differences in derived measures such as Apparent Coefficient ADC may arise which related to the or MRI method, but sample under study. Quality assurance using a standardized test object, phantom, is key factor standardizing across scanners. Methods Current diffusion phantoms either complex use, available larger quantities, contain substances unwanted clinical environment,...
Introduction Dynamic contrast-enhanced (DCE) MRI and arterial spin labeling (ASL) enable non-invasive measurement of renal blood flow (RBF), whereas oxygenation level-dependent (BOLD) enables the apparent relaxation rate (R2*), an indicator oxygenation. This study was conducted to evaluate potential role these modalities in assessing RBF dogs. The correlation between ultrasound (CEUS) examined also ability detect pharmacologically induced changes. Methods RBF, using CEUS, ASL- DCE-MRI, as...