Bo‐Michael Bellander
A5029840865- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- S100 Proteins and Annexins
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Optical Imaging and Spectroscopy Techniques
- Radiation Dose and Imaging
- Long-Term Effects of COVID-19
- Venous Thromboembolism Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Functional Brain Connectivity Studies
- Mechanical Circulatory Support Devices
- Clusterin in disease pathology
- Neonatal and fetal brain pathology
- Intensive Care Unit Cognitive Disorders
- Atomic and Subatomic Physics Research
- Autopsy Techniques and Outcomes
- Bacterial Infections and Vaccines
- Cancer, Hypoxia, and Metabolism
- Muscle and Compartmental Disorders
Karolinska University Hospital
2016-2025
Karolinska Institutet
2015-2024
University of Cambridge
2023-2024
Addenbrooke's Hospital
2024
Maastricht University
2023
University of Groningen
2022
University of Milano-Bicocca
2022
University of Oslo
2021
University Hospital of North Norway
2021
Heidelberg University
2021
ObjectiveWe aimed to explore the added value of common machine learning (ML) algorithms for prediction outcome moderate and severe traumatic brain injury.Study Design SettingWe performed logistic regression (LR), lasso regression, ridge with key baseline predictors in IMPACT-II database (15 studies, n = 11,022). ML included support vector machines, random forests, gradient boosting artificial neural networks were trained using same predictors. To assess generalizability predictions, we...
Brain-enriched protein biomarkers of tissue fate are being introduced clinically to aid in traumatic brain injury (TBI) management. The aim this study was determine how concentrations six different biomarkers, measured samples collected during the first weeks after TBI, relate severity and outcome. We included neurocritical care TBI patients that were prospectively enrolled from 2007 2013, all having one three blood drawn 2 weeks. analyzed S100 calcium-binding B (S100B), neuron-specific...
The complement cascade has been suggested to be involved in the development of secondary brain injuries following contusions, based on animal experiments. aim present study was examine possible involvement traumatic head injury human brain. Sixteen patients were included this study, 12-77 years age, treated at neurointensive care unit for contusions. All these operated with frontal or temporal lobe resection due intractable intracranial hypertension. resected tissue analyzed regard...
Coagulopathy is a common phenomenon in traumatic brain injury (TBI) and major contributor to poor outcome. Thrombocytopenia strong negative prognostic factor TBI, but bleeding tendency can be present even with normal platelet count. We investigated function patients TBI by means of modified thromboelastography (i.e., mapping [TEG-PM]). Four groups were studied: (1) severe isolated (n = 20), (2) general trauma without (the ICU group, n 10), (3) chronic alcohol abuse 7; as TBI), (4) healthy...
Traumatic brain injury (TBI) is responsible for up to 45% of in-hospital trauma mortality. Computed tomography (CT) central acute TBI diagnostics, and millions CT scans are conducted yearly worldwide. Though many studies have addressed individual predictors outcome from findings on scans, few done so a multivariate perspective. As these parameters interrelated in complex manner, there need better understanding them this context. 861 patients were reviewed according an extensive protocol. An...
In order to improve assessment and outcome prediction in patients suffering from traumatic brain injury (TBI), cerebral protein levels serum have been suggested as biomarkers of injury. However, despite much investigation, yet reach broad clinical utility TBI. This study is a 9-year follow-up experience the two most studied proteins, neuron-specific enolase (NSE) S100B, neuro-intensive care TBI population. Our aims were investigate what extent NSE independently combination, could predict...
Traumatic brain injury (TBI) is a common cause of death and disability, worldwide. Early determination severity essential to improve care. Neurofilament light (NF-L) has been introduced as marker neuroaxonal in neuroinflammatory/-degenerative diseases. In this study we determined the predictive power serum (s-) cerebrospinal fluid (CSF-) NF-L levels towards outcome, explored their potential correlation diffuse axonal (DAI). A total 182 patients suffering from TBI admitted neurointensive care...
The objective of the study was to examine how S100B, a biomarker traumatic brain injury (TBI), contributes outcome prediction after adjusting for known parameters, including age, Glasgow Coma Scale (GCS), pupil reaction, and computed tomography (CT) variables; which parameters have best correlation elevated serum levels S100B; investigate when sample S100B achieve strongest association outcome. This retrospective included 265 patients with TBI admitted neurointensive care unit, Karolinska...
Traumatic brain injury (TBI) is a major contributor to morbidity and mortality. Computerized tomography (CT) scanning of the essential for diagnostic screening intracranial injuries in need neurosurgical intervention, but may also provide information concerning patient prognosis enable baseline risk stratification clinical trials. Novel CT scoring systems have been developed improve current prognostic models, including Stockholm Helsinki scores, so far not extensively validated. The primary...
Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...
<h3>Importance</h3> A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown be associated outcomes. mild (mTBI; GCS 13-15), distribution and co-occurrence of pathological their prognostic importance are not well understood. <h3>Objective</h3> To identify adverse outcomes after mTBI....
Complex metabolic disruption is a crucial aspect of the pathophysiology traumatic brain injury (TBI). Associations between this and systemic metabolism their potential prognostic value are poorly understood. Here, we aimed to describe serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, its relationship severity patient outcome. We performed comprehensive metabolomics study in cohort 716 patients non-TBI reference (orthopedic, internal medicine, other...
Abstract Background While the Glasgow coma scale (GCS) is one of strongest outcome predictors, current classification traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormous heterogeneity in pathophysiology and treatment response. We hypothesized that data-driven characterization TBI could identify distinct endotypes give mechanistic insights. Methods developed an unsupervised statistical clustering model a mixture probabilistic graphs for...
Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...
Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation traumatic acute subdural hematoma (ASDH) until recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes primary DC craniotomy.We conducted an analysis centre treatment preference within prospective, multicentre, observational Collaborative European NeuroTrauma...
CPPopt denotes a Cerebral Perfusion Pressure (CPP) value at which the Pressure-Reactivity index, reflecting global state of Autoregulation, is best preserved. has been investigated as potential dynamically individualised CPP target in traumatic brain injury patients admitted intensive care unit. The prospective bedside use concept requires ensured safety and reliability recommended targets based on automatically-generated CPPopt. We aimed to: Increase stability automated algorithm by...
A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below individual lower limit reactivity (LLR) is associated mortality in traumatic brain injury (TBI) patients. We aim to validate this a large multicentre cohort.Recordings from 171 TBI patients high-resolution cohort CENTER-TBI were processed ICM+ software. derived LLR as trend CPP at level for which index (PRx) indicates impaired cerebrovascular low CPP. The...
We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs) on brain injury biomarker profiles, acute care requirements during intensive unit (ICU) stay, 6-month outcomes in patients with traumatic (TBI). From recruited to Collaborative European neurotrauma effectiveness research TBI (CENTER-TBI) study, we documented prevalence risk factors for SIs their effect levels biomarkers [S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), neurofilament light...