A5077748007- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Radiation Dose and Imaging
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Autopsy Techniques and Outcomes
- Respiratory Support and Mechanisms
- Clinical practice guidelines implementation
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Emergency and Acute Care Studies
- Vascular Malformations Diagnosis and Treatment
- Ethics in Clinical Research
- Healthcare Systems and Practices
- Older Adults Driving Studies
- Frailty in Older Adults
- S100 Proteins and Annexins
- Economic and Environmental Valuation
- Machine Learning in Healthcare
Medisch Centrum Haaglanden
2019-2025
Leiden University Medical Center
2013-2025
Leiden University
2022-2024
Haga Hospital
2019-2024
University of Groningen
2022
University Hospital of North Norway
2021-2022
University Hospital Heidelberg
2021
Radboud University Medical Center
2020-2021
Oslo University Hospital
2021
University of Oslo
2021
Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation traumatic acute subdural hematoma (ASDH) until recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes primary DC craniotomy.We conducted an analysis centre treatment preference within prospective, multicentre, observational Collaborative European NeuroTrauma...
Abstract Background Traumatic brain injury is associated with high rates of mortality and morbidity. Trauma patients a coagulopathy have 10-fold increased risk compared to without coagulopathy. The aim this study was identify the incidence relate early clinical outcome in traumatic intracranial hemorrhages. Methods Between September 2015 December 2016, 108 consecutive cranial trauma hemorrhages were included study. To assess relationship between outcome, chi-squared test performed. Results A...
OBJECTIVE The aim of this study was to compare the outcomes early (≤ 90 days) and delayed (> cranioplasty following decompressive craniectomy (DC) in patients with traumatic brain injury (TBI). METHODS authors analyzed participants enrolled Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) Neurotraumatology Quality Registry (Net-QuRe) studies who were diagnosed TBI underwent DC subsequent cranioplasty. These prospective, multicenter,...
In patients with anterior circulation aneurysmal Subarachnoid Haemorrhage (aSAH), endovascular coiling is currently practiced more frequently than neurosurgical clipping. However, despite multiple previous studies, it still uncertain whether favourable in terms of long-term clinical outcome.
Abstract Background Ruptured intracranial aneurysms resulting in subarachnoid haemorrhage can be treated by open surgical or endovascular treatment. Despite multiple previous studies, uncertainties on the optimal treatment practice still exists. The variation may result a variable, potentially worse, patient outcome. To better inform future strategies, this study aims to identify effectiveness of different strategies patients with ruptured investigating long-term functional outcome,...
Acute subdural hematoma (ASDH) due to traumatic brain injury (TBI) constitutes an increasing global health problem, especially in the elderly population. Treatment decisions on surgical versus conservative management pose a neurosurgical dilemma. Large practice variation exists between countries, hospitals, and individual neurosurgeons, illustrating presence of 'clinical equipoise'. The RESET-ASDH trial aimed address this dilemma but was terminated prematurely insufficient patient recruitment.
This epidemiological study analyzed the incidence, risk factors, hospital triage, and outcome of patients with severe traumatic brain injuries (sTBIs) caused by road traffic accidents (RTAs) admitted to hospitals in Trauma Center West-Netherlands (TCWN) region. registry data were used identify TBI all RTA victims mid-West region Netherlands from 2003 2011. Type head injury severity classified using Abbreviated Injury Scale (AIS). Head AIS scores ≥3 considered sTBI. Ten percent 12,503...
Evidence regarding the effect of surgery in traumatic intracerebral hematoma (t-ICH) is limited and relies on STITCH(Trauma) trial. This study aimed at comparing effectiveness early to conservative treatment patients with a t-ICH.In prospective cohort, we included large t-ICH (< 48 h injury). Primary outcome was Glasgow Outcome Scale Extended (GOSE) 6 months, analyzed multivariable proportional odds logistic regression. Subgroups injury severity isolated vs. non-isolated t-ICH.A total 367...
We aimed to investigate the extent of agreement on practices around brain death and postmortem organ donation. Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Regarding death, we found clinical evaluation (prerequisites neurological assessment) for determination (BDD) 100% centers. However, ancillary tests were required BDD 64% nondonor patients was...
The high occurrence and acute chronic sequelae of traumatic brain injury (TBI) cause major healthcare socioeconomic challenges. This study aimed to describe outcome, in-hospital consumption costs patients with TBI. We used data from hospitalised TBI that were included in the prospective observational CENTER-TBI three Dutch Level I Trauma Centres 2015 2017. Clinical was completed on costs. severity classified using Glasgow Coma Score (GCS). Patient outcome measured by mortality Outcome...
Abstract Background The rapidly increasing number of elderly (≥ 65 years old) with TBI is accompanied by substantial medical and economic consequences. An ASDH the most common injury in surgical versus conservative treatment this patient group remains an important clinical dilemma. Current BTF guidelines are not based on high-quality evidence compliance low, allowing for large international variation. RESET-ASDH trial multicenter RCT (cost-)effectiveness early neurosurgical hematoma...
Abstract Background The European Union (EU) aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required increase multicenter efficiency. We investigated IRB in a large prospective study on traumatic brain injury (TBI), aiming inform stimulate initiatives improve Methods reviewed relevant documents regarding submission approval from neurotrauma centers participating the Collaborative...
Treatment-limiting decisions (TLDs) can be inevitable severe traumatic brain injury (s-TBI) patients, but data on their use remain scarce. To investigate the prevalence, timing and considerations of TLDs in s-TBI patients. patients between 2008 2017 were analysed retrospecively. Patient data, timing, location, involvement proxies, reasons for collected. Baseline characteristics in-hospital outcomes compared with without TLDs. reported 117 270 (43.3%) 95.9% deaths after preceded by a TLD. The...
The decision whether to operate or not in patients with a traumatic acute subdural hematoma (t-ASDH) can, many cases, be neurosurgical dilemma. There is general conception that operating on severe cases leads the survival of severely disabled and associated relatively high medical costs. however little information quality life after operation for t-ASDH, let alone cost-effectiveness. This study retrospectively investigated patient outcome in-hospital costs 108 consecutive t-ASDH. Patient was...
Traumatic brain injury (TBI) is a global public health problem and leading cause of mortality, morbidity, disability. The increasing incidence combined with the heterogeneity complexity TBI will inevitably place substantial burden on systems. These findings emphasize importance obtaining accurate timely insights into healthcare consumption costs multi-national scale. This study aimed to describe intramural across full spectrum in Europe. Collaborative European NeuroTrauma Effectiveness...