A5026246944- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Nerve Disorders
- Orthopedic Surgery and Rehabilitation
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury Research
- Musculoskeletal pain and rehabilitation
- Tendon Structure and Treatment
- Management of metastatic bone disease
- Spinal Cord Injury Research
- Shoulder Injury and Treatment
- Cardiac Arrest and Resuscitation
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Neurogenesis and neuroplasticity mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Treatment
- Elbow and Forearm Trauma Treatment
- Shoulder and Clavicle Injuries
- Sepsis Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
Medisch Centrum Haaglanden
2016-2025
Leiden University Medical Center
2008-2024
Leiden University
2005-2024
Stiftung Liebenau (Germany)
2022
Addenbrooke's Hospital
2022
University of Cambridge
2022
Hutchinson (United Kingdom)
2022
KU Leuven
2022
Antwerp University Hospital
2022
University of Antwerp
2022
Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation traumatic acute subdural hematoma (ASDH) until recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes primary DC craniotomy.We conducted an analysis centre treatment preference within prospective, multicentre, observational Collaborative European NeuroTrauma...
Object. The aim of this retrospective study was to evaluate the restoration shoulder function by means suprascapular nerve neurotization in adult patients with proximal C-5 and C-6 lesions due a severe brachial plexus traction injury. primary goal reconstructive surgery restore biceps muscle and, secondarily, reanimate function. Methods. Suprascapular performed grafting 24 accessory or hypoglossal transfer 29 patients. Additional involving axillary 18 Postoperative needle electromyography...
Abstract Even after reconstructive surgery, major functional impairments remain in the majority of patients with peripheral nerve injuries. The application novel emerging therapeutic strategies, such as lentiviral (LV) vectors, may help to stimulate regeneration at a molecular level. In experiments described here, we examined effect LV vector‐mediated overexpression growth factor (NGF) and glial cell line‐derived neurotrophic (GDNF) on rat transection/repair model vivo . We showed that...
Neurosurgical management of traumatic brain injury (TBI) is challenging, with only low-quality evidence. We aimed to explore differences in neurosurgical strategies for TBI across Europe. A survey was sent 68 centers participating the Collaborative European Neurotrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) study. The questionnaire contained 21 questions, including decision when operate (or not) on acute subdural hematoma (ASDH) and intracerebral (ICH), perform a...
We employed Fast Blue (FB) axonal tracing to determine the origin of regenerating axons after thoracic spinal cord transection injury in rats. Schwann cell (SC)-loaded, biodegradable, poly(lactic-co-glycolic acid) (PLGA) scaffolds were implanted transection. Scaffolds loaded with solubilized basement membrane preparation (without SCs) used for negative controls, and nontransected cords positive controls. One or 2 months scaffold implantation, FB was injected 0–15 mm caudal about 5 rostral...
To satisfy different mechanical requirements in hard and soft tissue replacements, a series of biodegradable crosslinkable copolymers poly(propylene fumarate)‐ co ‐polycaprolactone (PPF‐ ‐PCL) are synthesized employed to fabricate 2D disks 3D scaffolds via photocrosslinking. Thermal properties such as the glass transition temperature ( T g ) melting m PPF‐ ‐PCL networks can be controlled efficiently by varying PCL composition φ ). As result, their vary significantly from stiff materials...
Abstract Background Early surgery in traumatic spinal fracture treatment may facilitate prompt mobilization, encountering affiliated complications. However, the safety and benefits of early are being questioned trauma patients. Therefore, objective this retrospective study is to investigate effect surgical timing on perioperative complications these Methods Spinal patients who underwent between 2010 2020 two Dutch Level-I centers were included retrospectively divided into an (< 24 h),...
Current opinion holds that pores in synthetic nerve guides facilitate regeneration. Solid factual support for this opinion, however, is absent; most of the relevant studies assessed only morphological parameters and results have been contradictory. To evaluate effect pores, rat sciatic was either autografted or grafted with nonporous, macroporous (10-230 mum), microporous (1-10 microm) biodegradable epsilon-caprolactone grafts. Twelve weeks later, nerves were resected, electrophysiological...
Several recent global traumatic brain injury (TBI) initiatives rely on practice variation in diagnostic and treatment methods to answer effectiveness questions.One of these scientific dilemmas, the surgical management acute subdural hematoma (ASDH) might be variable among countries, centers within even neurosurgeons a center, hence amenable for comparative study.The aim our questionnaire, therefore, was explore variations ASDH similar densely populated geographical area.An online involving...
OBJECTIVE The performance of surgery for spinal metastases is rapidly increasing. Different surgical procedures, ranging from stabilization alone to combined with corpectomy, are thereby performed various indications. Little known about the impact these different procedures on patient quality life (QOL), but this factor crucial when discussing therapeutic options patients and their families. Thus, authors study investigated effect QOL. METHODS prospectively followed a cohort 113 who were...
Observer variability in local radiological reading is a major concern large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of study compare with TBI imaging datasets and investigate the added value review. total 2050 admission computed tomography (CT) scans from subjects enrolled Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) were analyzed for seven main...
OBJECTIVE The aim of this study was to compare the outcomes early (≤ 90 days) and delayed (> cranioplasty following decompressive craniectomy (DC) in patients with traumatic brain injury (TBI). METHODS authors analyzed participants enrolled Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) Neurotraumatology Quality Registry (Net-QuRe) studies who were diagnosed TBI underwent DC subsequent cranioplasty. These prospective, multicenter,...
An anatomic study of the distal spinal accessory nerve (SAN) to determine number myelinated axons and feasibility posterior harvest for direct neurotization targets was performed. Ten fresh human cadavers were studied. A supraclavicular approach performed followed by a approach. The relationship SAN bony landmarks (T1 spinous process, acromioclavicular joint, posterolateral corner acromium, angle at superior medial border scapula) as well maximal harvestable length recorded. After...