Thijs Vande Vyvere
A5080552317- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Radiation Dose and Imaging
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Medical Imaging Techniques and Applications
- Alzheimer's disease research and treatments
- Cancer survivorship and care
- Machine Learning in Healthcare
- Pain Management and Opioid Use
- Functional Brain Connectivity Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Emergency and Acute Care Studies
- Autopsy Techniques and Outcomes
Antwerp University Hospital
2016-2025
University of Antwerp
2016-2025
Pain in Motion
2022-2024
Icometrix (Belgium)
2016-2023
Addenbrooke's Hospital
2022
University of Groningen
2022
University of Cambridge
2022
University Hospital Heidelberg
2021
Innsbruck Medical University
2020-2021
Universität Innsbruck
2020-2021
Serum biomarkers may inform and improve care in traumatic brain injury (TBI). We aimed to correlate serum with clinical severity, path imaging abnormalities TBI, explore their incremental value over characteristics predicting computed tomographic (CT) abnormalities.
The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which aging Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions involved tissues, CSF abnormalities reported these conditions are suggestive ChP injury. Indeed, several studies document damage AD, nevertheless remains to be systematically characterized. We here report that changes elicited by AD consistent with a perturbed...
Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...
In this paper a Computer Aided Detection (CAD) system is presented to automatically detect Cerebral Microbleeds (CMBs) in patients with Traumatic Brain Injury (TBI). It believed that the presence of CMBs has clinical prognostic value TBI patients. To study contribution patient outcome, accurate detection required. Manual time consuming task prone errors, because are easily overlooked and difficult distinguish from blood vessels. This included 33 Because laborious nature manually annotating...
Traumatic brain injury is a complex and diverse medical condition with high frequency of intracranial abnormalities. These can typically be visualized on computed tomography (CT) scan, which provides important information for further patient management, such as the need operative intervention. In order to quantify extent acute lesions associated secondary injuries, midline shift cisternal compression, visual assessment CT images has limitations, including observer variability lack...
BackgroundWe aimed to understand the relationship between serum biomarker concentration and lesion type volume found on computed tomography (CT) following all severities of TBI.MethodsConcentrations six biomarkers (GFAP, NFL, NSE, S100B, t-tau UCH-L1) were measured in samples obtained <24 hours post-injury from 2869 patients with TBI, enrolled CENTER-TBI prospective cohort study (NCT02210221). Imaging phenotypes defined as intraparenchymal haemorrhage (IPH), oedema, subdural haematoma (SDH),...
Persistent symptoms after mild traumatic brain injury (mTBI) represent a major public health problem.To identify neuroanatomical substrates of mTBI and the optimal timing for magnetic resonance imaging (MRI).This prospective multicenter cohort study encompassed all eligible patients from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) (December 19, 2014, to December 17, 2017) local (November 20, 2012, 2013). Patients presented hospital within...
Head computed tomography (CT) is a routinely performed examination to assess the intracranial condition of patients with traumatic brain injury (TBI), and radiological findings can help indicate presence hypertension. At present, prediction hypertension mainly based on manual discrimination imaging characteristics. The aim our study was establish model predict via fully automatic CT image segmentation, rigorous radiomic feature extraction reliable development validation. Patients admitted...
Observer variability in local radiological reading is a major concern large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of study compare with TBI imaging datasets and investigate the added value review. total 2050 admission computed tomography (CT) scans from subjects enrolled Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) were analyzed for seven main...
BackgroundEven patients with normal computed tomography (CT) head imaging may experience persistent symptoms for months to years after mild traumatic brain injury (mTBI). There is currently no good way predict recovery and triage who benefit from early follow-up targeted intervention. We aimed assess if existing prognostic models can be improved by serum biomarkers or diffusion tensor metrics (DTI) MRI, identify DTI.MethodsWe included 1025 aged >18 a Glasgow Coma Score >12 CT the...
The aim of this study is to investigate the prognostic value using National Institute Neurological Disorders and Stroke (NINDS) standardized imaging-based pathoanatomic descriptors for evaluation reporting acute traumatic brain injury (TBI) lesions. For a total 3392 patients (2244 males 1148 females, median age = 51 years) enrolled in Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) study, we extracted 96 Common Data Elements (CDEs) from...
Abstract Background Magnetic resonance imaging (MRI) carries prognostic importance after traumatic brain injury (TBI), especially when computed tomography (CT) fails to fully explain the level of unconsciousness. However, in critically ill patients, risk deterioration during transfer needs be balanced against benefit detecting prognostically relevant information on MRI. We therefore aimed assess if day serum protein biomarkers could identify TBI patients whom risks are compensated by...
BACKGROUND AND OBJECTIVES: Guideline recommendations for surgical management of traumatic epidural hematomas (EDHs) do not directly address EDHs that co-occur with other intracranial hematomas; the relative rates isolated vs nonisolated and guideline adherence are unknown. We describe characteristics a contemporary cohort patients identify factors influencing acute surgery. METHODS: This research was conducted within longitudinal, observational Collaborative European NeuroTrauma...
Abstract Repeated mild traumatic brain injury is of growing interest regarding public and sporting safety thought to have greater adverse or cumulative neurological effects when compared with single injury. While epidemiological links between repeated outcome been investigated in humans, exploration its mechanistic substrates has largely undertaken animal models. We acute repeat (n = 21) that healthy controls 76) using resting-state functional MRI quantified thalamic connectivity, given...
Computer Tomography (CT) is the gold standard technique for brain damage evaluation after acute Traumatic Brain Injury (TBI). It allows identification of most lesion types and determines need surgical or alternative therapeutic procedures. However, traditional approach classification restricted to visual image inspection. In this work, we characterize predict TBI lesions by using CT-derived radiomics descriptors. Relevant shape, intensity texture biomarkers characterizing different are...
<h3>Importance</h3> An interview is considered the gold standard method of assessing global functional outcomes in clinical trials among patients with acute traumatic brain injury (TBI). However, several multicenter have used questionnaires completed by a patient or caregiver to assess primary end point. <h3>Objective</h3> To examine agreement between and questionnaire formats for TBI consider whether an has advantages. <h3>Design, Setting, Participants</h3> This cohort study data from...