A5033111238- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- S100 Proteins and Annexins
- Intracerebral and Subarachnoid Hemorrhage Research
- Hip and Femur Fractures
- Airway Management and Intubation Techniques
- Musculoskeletal pain and rehabilitation
- Functional Brain Connectivity Studies
- Emergency and Acute Care Studies
- Educational and Psychological Assessments
- Advanced MRI Techniques and Applications
- Palliative Care and End-of-Life Issues
- Radiomics and Machine Learning in Medical Imaging
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Resilience and Mental Health
- Sepsis Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Medical Imaging Techniques and Applications
Radboud University Nijmegen
2007-2015
Radboud University Medical Center
2007-2014
Future Diagnostics (Netherlands)
2010
Biomarker levels in blood after traumatic brain injury (TBI) may offer diagnostic and prognostic tools addition to clinical indices. This study aims validate glial fibrillary acidic protein (GFAP) S100B concentrations as outcome predictors of TBI using cutoff 1.5 μg/L for GFAP 1.13 from a previous study.In 79 patients with (Glasgow Coma Scale score [GCS] ≤12), serum, taken at hospital admission, was analyzed S100B. Data collected included mechanism, age, gender, mass lesion on CT, GCS,...
Changes in the demographics, approach, and treatment of traumatic brain injury (TBI) patients require regular evaluation epidemiological profiles, severity classification, outcomes. This prospective multicenter study provides detailed information on TBI-related variables 508 moderate-to-severe TBI patients. Variability epidemiology outcome is examined by comparing our cohort with previous studies. Additionally, relation between classification assessed at different time points studied. Based...
To evaluate the whole-brain resting-state networks in a homogeneous group of patients with acute mild traumatic brain injury (MTBI) and to identify alterations functional connectivity induced by MTBI.Thirty-five MTBI 35 healthy control subjects, matched age, gender, handedness, education, underwent fMRI, susceptibility weighted imaging, neuropsychological, postconcussive symptom assessments. We ensured homogeneity patient limiting mechanism fronto-occipital impacts. Alterations were analyzed...
The impact of disability following traumatic brain injury (TBI), assessed by functional measurement scales for TBI or health-related quality life (HRQoL), may vary because a number factors, including presence depression post-traumatic stress disorder (PTSD). aim this study was to assess prevalence and PTSD on outcome HRQoL six 12 months mild TBI. We selected sample 1919 patients who presented the emergency department (ED) followed either hospital admission discharge home environment....
Several prognostic models to predict outcome in traumatic brain injury (TBI) have been developed, but few are externally validated. We aimed validate the International Mission on Prognosis and Analysis of Clinical Trials TBI (IMPACT) a recent unselected patient cohort assess additional value extracranial injury.The Prospective Observational COhort Neurotrauma (POCON) registry contains 508 patients with moderate or severe TBI, who were admitted 2008 2009 five trauma centers Netherlands....
In this paper a Computer Aided Detection (CAD) system is presented to automatically detect Cerebral Microbleeds (CMBs) in patients with Traumatic Brain Injury (TBI). It believed that the presence of CMBs has clinical prognostic value TBI patients. To study contribution patient outcome, accurate detection required. Manual time consuming task prone errors, because are easily overlooked and difficult distinguish from blood vessels. This included 33 Because laborious nature manually annotating...
Objective: This study compares inter-rater-reliability, lesion detection and clinical relevance of T2-weighted imaging (T2WI), Fluid Attenuated Inversion Recovery (FLAIR), T2*-gradient recalled echo (T2*-GRE) Susceptibility Weighted Imaging (SWI) in Traumatic Brain Injury (TBI).Methods: Three raters retrospectively scored 56 TBI patients' MR images (12–76 years old, median TBI-MRI interval 7 weeks) on number, volume, location intensity. Punctate lesions (diameter <10 mm) were separately from...
Primary objective: To compare consecutive Mild Traumatic Brain Injury (MTBI) patients with and without adequate effort on cognitive performance, litigation status, fatigue, distress personality.Research design: (Neuro)psychological assessment was done 6 months post-injury in 110 from a cohort of 618 MTBI aged 18–60, who attended the emergency department our level I trauma centre. Effort tested Amsterdam Short Term Memory test.Main outcome results: Thirty (27%) failed test. Poor associated...
To determine adherence to Brain Trauma Foundation guidelines for intracranial pressure monitoring after severe traumatic brain injury, investigate if characteristics of patients treated according (ICP+) differ from those who were not (ICP-), and whether guideline compliance is related 6-month outcome.Observational multicenter study.Consecutive injury (≥16 yrs, n = 265) meeting criteria monitoring.Data on demographics, severity, computed tomography findings, patient management registered. The...
This prospective multicenter study investigated the association of course coagulation abnormalities with initial computed tomography (CT) characteristics and outcome in patients isolated traumatic brain injury (TBI). Patient demographics, parameters, CT characteristics, data moderate severe TBI without major extracranial injuries were prospectively collected. Coagulopathy was defined as absent, early but temporary, delayed, or sustained. Delayed/sustained coagulopathy associated a higher...
Prevention of secondary prehospital risk factors such as hypoxia and hypotension is likely to improve patient prognosis in severe traumatic brain injury (TBI). Because the Dutch trauma care organization characterized by fast access specialized due geographical situation, we investigated whether what extend factors, hypotension, measures, endotracheal intubation, affect outcome TBI context a region with care.The medical records 339 subsequent computed tomography-confirmed patients Glasgow...
Observational studies of interventions are at risk for confounding by indication. The objective the current study was to define circumstances validity methods adjust indication in observational studies.We performed post hoc analyses data prospectively collected from three European and North American traumatic brain injury including 1,725 patients. effects (intracranial pressure [ICP] monitoring, intracranial operation primary referral) were estimated a proportional odds regression model with...
Although guidelines have been developed to standardize care in traumatic brain injury, between-center variation treatment approach has frequently reported. We examined for injury by assessing factors influencing and the association between patient outcome.Secondary analysis of prospectively collected data.Five level I trauma centers Netherlands (2008-2009).Five hundred three patients with moderate or severe (Glasgow Coma Scale, 3-13).We seven parameters: direct transfer, involvement mobile...
Primary objective: To investigate how the type of stimulus (pictures or words) and method reproduction (free recall recognition after a short long delay) affect sensitivity specificity 3-item memory test in assessment post traumatic amnesia (PTA).Methods: Daily testing was performed 64 consecutively admitted brain injured patients, 22 orthopedically patients 26 healthy controls until criteria for resolution PTA were reached. Subjects randomly assigned to with visual verbal stimuli. Short...
Brain micro-bleeds (BMBs) are used as surrogate markers for detecting diffuse axonal injury in traumatic brain (TBI) patients. The location and number of BMBs have been shown to influence the long-term outcome TBI. To further study importance prognosis, accurate localization quantification required. task annotating is laborious, complex prone error, resulting a high inter- intra-reader variability. In this paper we propose computer-aided detection (CAD) system automatically detect MRI scans...
Abstract Background Post-traumatic amnesia (PTA) is a key symptom of traumatic brain injury (TBI). Accurate assessment PTA imperative in guiding clinical decision making. Our aim was to develop and externally validate short, examiner independent practical scale, by selecting the most discriminative items from existing scales using three-word memory test. Methods Mild, moderate severe TBI patients control subjects were assessed two separate cohorts, one for derivation validation,...