A5108081443- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Non-Invasive Vital Sign Monitoring
- Surgical site infection prevention
- Sepsis Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Mechanical Circulatory Support Devices
- SARS-CoV-2 detection and testing
- Mycobacterium research and diagnosis
- Cardiac Ischemia and Reperfusion
- Ultrasound in Clinical Applications
- Antibiotics Pharmacokinetics and Efficacy
- Biosensors and Analytical Detection
- Traumatic Brain Injury and Neurovascular Disturbances
- Abdominal Surgery and Complications
- HIV/AIDS Research and Interventions
Median SCP (Spain)
2025
Grifols (Spain)
2000-2025
Hospital Clínico Universitario de Valencia
2011-2023
Universitat de València
2012-2023
Hospital Israelita Albert Einstein
2021
Hospital General Universitario de Ciudad Real
2015
INCLIVA Health Research Institute
2012-2014
Hospital Universitari de Vic
2010
Weatherford College
2006
Rutgers, The State University of New Jersey
2004
ContextSupplemental perioperative oxygen has been variously reported to halve or double the risk of surgical wound infection.ObjectiveTo test hypothesis that supplemental reduces infection in patients following colorectal surgery.Design, Setting, and PatientsA double-blind, randomized controlled trial 300 aged 18 80 years who underwent elective surgery 14 Spanish hospitals from March 1, 2003, October 31, 2004. Wound infections were diagnosed by blinded investigators using Centers for Disease...
Monitoring plays an important role in the current management of patients with acute respiratory failure but sometimes lacks definition regarding which 'signals' and 'derived variables' should be prioritized as well specifics related to timing (continuous versus intermittent) modality (static dynamic). Many new techniques monitoring have been made available for clinical use recently, their place is not always defined. Appropriate correct interpretation data provided can help improve our...
BACKGROUND: We investigated whether individualized positive end-expiratory pressure (PEEP) improves oxygenation, ventilation, and lung mechanics during one-lung ventilation compared with standardized PEEP. METHODS: Thirty patients undergoing thoracic surgery were randomly allocated to the study or control group. Both groups received an alveolar recruitment maneuver at beginning end of ventilation. After maneuver, group had their lungs ventilated a 5 cm·H2O PEEP, while PEEP level determined...
After experimental conditions were established, 366 strains of mycobacteria belonging to 23 different species studied for fatty acids, secondary alcohols, and mycolic acid cleavage products by capillary gas-liquid chromatography. Additionally, the pattern was thin-layer Capillary chromatography allowed direct identification following Mycobacterium spp.: M. kansasii, marinum, szulgai, xenopi, malmoense, gordonae. The patterns methyl esters recorded test chelonae agri may be value in these...
Pulmonary complications of neuromuscular disease can be averted by increasing peak cough flows with the use a forced exsufflation device. The purpose this study was to examine pressure, volume, and flow relationships for range settings generated device, compare them clinically efficacious values manufacturer's guidelines.The In-exsufflator connected standard lung model. resulting deflation volumes, flows, pressures were averaged over 10 cycles at each setting.The set insufflation...
Three hundred patients were enrolled in a double-blind, randomized, controlled study designed to investigate the ability of supplemental perioperative oxygen reduce wound infection. Participants age 18 80 years, had no coexisting serious medical conditions, and scheduled undergo elective colorectal surgery at one 14 participating hospitals Spain. No undergoing minor or laparoscopic included. Anesthesia antibiotic prophylaxis standardized for study. Patients randomized by computer-generated...
Acute respiratory distress syndrome is characterised by activation of the inflammatory cascade. The only treatment that reduces mortality rate associated with this lung protective ventilation, which requires sedation patients. Sedation in critical care units usually induced intravenously, although there reason to believe inhaled anaesthetics are a suitable alternative. Sevoflurane has recently been shown modulate response model injury more favourably than propofol.The goal study was confirm...
Volatile anaesthetics may have direct cardioprotective properties due to effects similar ischaemic preconditioning and postconditioning. Clinical results in cardiac surgery patients are controversial be related the timing of administration intraoperatively.We hypothesised that effect sevoflurane coronary bypass graft surgical would greater if during anaesthesia continued ICU for at least 4 h postoperatively until weaning from mechanical ventilation.Double-blind, double-dummy, prospective,...
Background Low tidal volume (VT) during anesthesia minimizes lung injury but may be associated to a decrease in functional impairing mechanics and efficiency. Lung recruitment (RM) can restore this critically depend on the post-RM selected PEEP. This study was randomized, two parallel arm, open whose primary outcome compare effects driving pressure of adding RM low-VT ventilation, with or without an individualized PEEP patients known previous disease anesthesia. Methods Consecutive scheduled...
To assess the diagnostic accuracy of peripheral capillary oxygen saturation (SpO2) while breathing room air for 5 min (the 'Air-Test') in detecting postoperative atelectasis.Prospective cohort study. Diagnostic was assessed by measuring agreement between index test and reference standard CT scan images.Postanaesthetic care unit a tertiary hospital Spain.Three hundred fifty patients from 12 January to 7 February 2015; 170 scheduled surgery under general anaesthesia who were admitted into...
We evaluated a commercially available radioimmunoassay technique for detecting the soluble antigen of Legionella pneumophila serogroup 1 using concentrated and nonconcentrated urine. Concentration was achieved by selective ultrafiltration. The sensitivity 60.9% urine 80.4% samples, with 100% specificity in both cases.
Postoperative pulmonary and non-pulmonary complications are common problems that increase morbidity mortality in surgical patients, even though the incidence has decreased with increased use of protective lung ventilation strategies. Previous trials have focused on standard strategies intraoperative or postoperative period, but without personalizing these to suit needs each individual patient considering both periods as a global perioperative lung-protective approach. The trial presented...
Observer variability in local radiological reading is a major concern large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of study compare with TBI imaging datasets and investigate the added value review. total 2050 admission computed tomography (CT) scans from subjects enrolled Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) were analyzed for seven main...
BACKGROUND: During lobectomy in patients with lung cancer, the operated is often collapsed and hypoperfused. Ischemia/reperfusion injury may then occur when re-expanded. We hypothesized that remote ischemic preconditioning (RIPC) would decrease oxidative damage improve gas exchange postoperative period. METHODS: conducted a single-center, randomized, double-blind trial nonsmall cell cancer undergoing elective lobectomy. Fifty-three were randomized to receive limb RIPC immediately after...
To correlate the air flows generated by mechanical insufflation-exsufflation as a function of pressure delivery in lung model at two pulmonary compliance and three airway resistance settings.With each combination compliances 25 50 ml/cm H2O resistances 6, 11, 17 cm H2O/liter/sec, ten cycles were applied using deliveries 40 to -40, -50, 60 -60, 70 -70 H2O. The resulting peak exsufflation volumes recorded.In multivariate analysis, compliance, resistance, all found significantly affect such...
Anidulafungin is indicated as a first-line treatment for invasive candidiasis in critically ill patients. In the intensive care unit, sepsis main cause of acute renal failure, and with continuous replacement therapy (CRRT) has increased recent years. Antimicrobial pharmacokinetics affected by CRRT, but few studies have addressed optimal dosage anidulafungin during CRRT.We included 12 patients who received venovenous haemodiafiltration to treat failure. was infused on 3 consecutive days,...