A5024747943- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Nitric Oxide and Endothelin Effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Anesthesia and Neurotoxicity Research
- Vitamin C and Antioxidants Research
- Cardiac and Coronary Surgery Techniques
- Transplantation: Methods and Outcomes
- Hydrogen's biological and therapeutic effects
- Neonatal Respiratory Health Research
- Ion Transport and Channel Regulation
- Abdominal Surgery and Complications
- Antioxidant Activity and Oxidative Stress
- Fuel Cells and Related Materials
- Asthma and respiratory diseases
- Airway Management and Intubation Techniques
- Enhanced Recovery After Surgery
- Phonocardiography and Auscultation Techniques
- High Altitude and Hypoxia
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular and Diving-Related Complications
- Non-Invasive Vital Sign Monitoring
- Hernia repair and management
- Sulfur Compounds in Biology
INCLIVA Health Research Institute
2013-2021
Hospital Clínico Universitario de Valencia
2008-2019
Universitat de València
1996-2017
Paracelsus Medical University
2011
The aim of the present study was to determine whether glutathione oxidation occurs in chronic obstructive pulmonary disease (COPD) patients who perform exercise and this could be prevented. Blood red-ox ratio [oxidized-to-reduced (GSSG/ GSH)] significantly increased when performed for a short period time until exhaustion. Their resting blood GSSG/GSH 0.039 +/- 0.008 (SD) (n = 5), whereas after it 0.085 0.019, P < 0.01. Glutathione associated with partially prevented by oxygen therapy...
BACKGROUND: During lobectomy in patients with lung cancer, the operated is often collapsed and hypoperfused. Ischemia/reperfusion injury may then occur when re-expanded. We hypothesized that remote ischemic preconditioning (RIPC) would decrease oxidative damage improve gas exchange postoperative period. METHODS: conducted a single-center, randomized, double-blind trial nonsmall cell cancer undergoing elective lobectomy. Fifty-three were randomized to receive limb RIPC immediately after...
Myocardial oxidative stress plays an essential role in the pathogenesis of ischaemia-reperfusion injury associated with coronary artery bypass grafting (CABG). Both propofol and volatile anaesthetics have been shown to reduce reactive oxygen species experimental clinical studies.To compare influence sevoflurane on myocardial markers (F2-isoprostanes nitrates/nitrites) sinus blood samples from patients undergoing off-pump CABG.Randomised controlled study scheduled for CABG a tertiary academic...
During lung lobectomy, the operated is collapsed and hypoperfused; oxygen deprivation accompanied by reactive hypoxic pulmonary vasoconstriction. After ischaemia present in state followed expansion–reperfusion injury attributed to production of species. The primary objective this study was investigate time course several markers oxidative stress simultaneously exhaled breath condensate blood determine relationship between one-lung ventilation patients undergoing lobectomy. This...
BackgroundCardiopulmonary bypass (CPB) in on-pump cardiac surgery can have harmful systemic effects, triggered part by radical oxygen species (ROS) produced ischemia-reperfusion the heart and lung. We determined relationship between levels of oxidative stress markers (8-isoprostane nitrites/nitrates) plasma with aortic cross clamp duration patients undergoing CPB.MethodsThirty CPB were studied: 14 coronary artery graft 16 valve surgery. Plasma 8-isoprostane, nitrites/nitrates measured over a...
Mechanical ventilation (MV) can induce or worsen pulmonary oedema. Aquaporins (AQPs) facilitate the selective and rapid bi-directional movement of water. Their role in development resolution oedema is controversial. Our objectives are to determine if prolonged MV causes lung changes expression AQP 1 5 rats.25 male Wistar rats were subjected with a tidal volume 10 ml/kg, during 2 hours (n = 12) 4 13). Degree was compared group non-ventilated 5). The determined by western immunoblotting,...
New Findings What is the central question of this study? Although different studies have attempted to find factors that influence expression aquaporins (AQPs) in lung situations, date no research group has explored AQP1 and AQP5 jointly rats mechanically ventilated with tidal volumes a model ventilator‐induced injury. main finding? Mechanical ventilation high volume causes injury oedema, increasing permeability. In volume, pulmonary decreases. We analysed 1 5 its relation Forty‐two were...
In knee surgery a tourniquet is usually applied in order to provide bloodless surgical field. This study aims compare, tourniquet-induced ischemia-reperfusion model, the glutathione oxidation and lipid peroxidation two different blood sources: an operated drainage tube or antecubital vein.Thirty-two patients undergoing total replacement were studied. We measured reduced (GSH), oxidized (GSSG), malondialdehyde (MDA) other metabolic parameters from (17 patients), vein (15 patients) before...
BackgroundGut manipulation during surgery may induce local oxidative stress. Supplemental inspired oxygen increases arterial and tissue partial pressures. This study examined whether a 0.80 fraction of (FiO2) attenuates the stress, reducing xanthine oxidase (XO) activity in colonic mucosa as possible mechanism colon surgery.MethodsTwenty-four cancer patients who underwent elective resection were randomly assigned to either 0.30 FiO2 or surgery. Malondialdehyde (MDA) oxidized glutathione...
During lung lobectomy, the operated completely collapses with simultaneous hypoxic pulmonary vasoconstriction, followed by expansion and reperfusion. Here, we investigated glutathione oxidation lipoperoxidation in patients undergoing during one-lung ventilation (OLV) after resuming two-lung (TLV), examined relationship OLV duration.We performed a single-centre, observational, prospective study 32 lobectomy. Blood samples were collected at five time-points: T0, pre-operatively; T1, OLV, 5...
A major limitation in the use of AZT for AIDS treatment is occurrence side effects, such as leukopenia. The effects antioxidant vitamins C and E on AZT-induced leukopenia were investigated mice. Mice divided into four groups: (1) controls; (2) AZT-treated; (3) treated with plus E; (4) pre-treated then vitamins. Our results demonstrate that causes mice, which was abrogated by administration group. These prevented decrease cellular content induced bone marrow diminished peroxide levels myeloid...
García-de-la-Asunción, J.; Perez-Griera, García-Raimundo, M.; Bruno, L.; Martí, F.; Belda, F. J. Author Information
García-de-la-Asunción, J.; Bruno, L.; Sapena, M. García-Raimundo, M.; Llorens, J. Author Information
García-de-la-Asunción, J.; Martí, F.; Bruno, L.; García-Raimundo, M.; Belda, F. J. Author Information
Sánchez, Moreno T.; Perez-Giera, J.; Delgado, C.; Pastor, E.; Belda, F. García-de-la-Asuncion, J. Author Information