Marina Soro
A5046129063- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Neonatal Respiratory Health Research
- Abdominal Surgery and Complications
- Family and Patient Care in Intensive Care Units
- Renal function and acid-base balance
- Non-Invasive Vital Sign Monitoring
- Immune Response and Inflammation
- Ultrasound in Clinical Applications
- Mechanical Circulatory Support Devices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Optical Imaging and Spectroscopy Techniques
- Surgical site infection prevention
- Neuroscience of respiration and sleep
- Inflammation biomarkers and pathways
- Heart Failure Treatment and Management
- Neonatal Health and Biochemistry
Hospital Clínico Universitario de Valencia
2015-2024
Austin Hospital
2024
Hospital Israelita Albert Einstein
2024
Monash University
2024
Institut National d’Hygiène Publique
2024
Clinical Research Institute
2023
INCLIVA Health Research Institute
2013-2023
Universitat de València
2007-2019
Angelini Pharma (Italy)
2017
Centre Hospitalier Universitaire Ibn Rochd
2015
BACKGROUND: We investigated whether individualized positive end-expiratory pressure (PEEP) improves oxygenation, ventilation, and lung mechanics during one-lung ventilation compared with standardized PEEP. METHODS: Thirty patients undergoing thoracic surgery were randomly allocated to the study or control group. Both groups received an alveolar recruitment maneuver at beginning end of ventilation. After maneuver, group had their lungs ventilated a 5 cm·H2O PEEP, while PEEP level determined...
Acute respiratory distress syndrome is characterised by activation of the inflammatory cascade. The only treatment that reduces mortality rate associated with this lung protective ventilation, which requires sedation patients. Sedation in critical care units usually induced intravenously, although there reason to believe inhaled anaesthetics are a suitable alternative. Sevoflurane has recently been shown modulate response model injury more favourably than propofol.The goal study was confirm...
Volatile anaesthetics may have direct cardioprotective properties due to effects similar ischaemic preconditioning and postconditioning. Clinical results in cardiac surgery patients are controversial be related the timing of administration intraoperatively.We hypothesised that effect sevoflurane coronary bypass graft surgical would greater if during anaesthesia continued ICU for at least 4 h postoperatively until weaning from mechanical ventilation.Double-blind, double-dummy, prospective,...
Background Low tidal volume (VT) during anesthesia minimizes lung injury but may be associated to a decrease in functional impairing mechanics and efficiency. Lung recruitment (RM) can restore this critically depend on the post-RM selected PEEP. This study was randomized, two parallel arm, open whose primary outcome compare effects driving pressure of adding RM low-VT ventilation, with or without an individualized PEEP patients known previous disease anesthesia. Methods Consecutive scheduled...
Although much has evolved in our understanding of the pathogenesis and factors affecting outcome patients with acute respiratory distress syndrome (ARDS), still there is no specific pharmacologic treatment for ARDS. Several clinical trials have evaluated utility corticoids but none them demonstrated a definitive benefit due to small sample sizes, selection bias, patient heterogeneity, time initiation or duration therapy. We postulated that adjunctive persistent ARDS intravenous dexamethasone...
To assess the diagnostic accuracy of peripheral capillary oxygen saturation (SpO2) while breathing room air for 5 min (the 'Air-Test') in detecting postoperative atelectasis.Prospective cohort study. Diagnostic was assessed by measuring agreement between index test and reference standard CT scan images.Postanaesthetic care unit a tertiary hospital Spain.Three hundred fifty patients from 12 January to 7 February 2015; 170 scheduled surgery under general anaesthesia who were admitted into...
In Brief BACKGROUND: The Anesthetic-Conserving Device (AnaConDa) can be used to administer inhaled anesthetics using an intensive care unit (ICU) ventilator. We evaluated the predictive performance of a simple manually adjusted pump infusion scheme, for liquid sevoflurane AnaConDa. METHODS: studied 50 ICU patients who received via They were randomly divided into three groups. A 6-h anesthetic was according scheme target end-tidal concentration 1% (Group 1%, n = 15) and 1.5% 1.5%, 15)....
Postoperative pulmonary and non-pulmonary complications are common problems that increase morbidity mortality in surgical patients, even though the incidence has decreased with increased use of protective lung ventilation strategies. Previous trials have focused on standard strategies intraoperative or postoperative period, but without personalizing these to suit needs each individual patient considering both periods as a global perioperative lung-protective approach. The trial presented...
Abstract Sepsis is a common cause of acute respiratory distress syndrome (ARDS) associated with high mortality. A panel biomarkers (BMs) to identify septic patients at risk for developing ARDS, or death, would be interest selecting therapeutic trials, which could improve ARDS diagnosis and treatment, survival chances in sepsis ARDS. We measured nine protein BMs by ELISA serum from 232 adult (152 required invasive mechanical ventilation 72 had ARDS). including the RAGE, CXCL16 Ang-2, plus PaO...
BACKGROUND: During lobectomy in patients with lung cancer, the operated is often collapsed and hypoperfused. Ischemia/reperfusion injury may then occur when re-expanded. We hypothesized that remote ischemic preconditioning (RIPC) would decrease oxidative damage improve gas exchange postoperative period. METHODS: conducted a single-center, randomized, double-blind trial nonsmall cell cancer undergoing elective lobectomy. Fifty-three were randomized to receive limb RIPC immediately after...
Abstract Background Acute respiratory distress syndrome (ARDS) is associated with high mortality in Intensive Care Units (ICU). A previous genome-wide association study (GWAS) identified the vascular endothelial growth factor receptor 1 ( VEGFR1 ) gene ARDS risk. We performed a GWAS on soluble (sVEGFR1) levels to identify protein quantitative trait loci (pQTLs) and genes of interest for ARDS. Methods Serum samples (n=292) within first 24 (T1), 72 hours (T2), 7 days (T7) after sepsis...
Less-invasive and easy to install monitoring systems for continuous estimation of cardiac index (CI) have gained increasing interest, especially in surgery patients who often exhibit abrupt haemodynamic changes. The aim the present study was compare accuracy CI by a new semi-invasive system with transpulmonary thermodilution before after cardiopulmonary bypass (CPB). Sixty-five (41 Germany, 24 Spain) scheduled elective coronary were studied CPB, respectively. Measurements included obtained...
World Health Organization and the United States Center for Disease Control have recently recommended use of 0.8 FIO 2 in all adult surgical patients undergoing general anaesthesia, to prevent site infections.This recommendation has arisen several discussions: As a matter fact, there are numerous studies with different results about effect on infection.Moreover, clinical effects not limited infection control.
BACKGROUND: Postoperative pulmonary complications (PPCs) are common in high-risk surgical patients. ventilatory management may improve their outcome. Supplemental oxygen through a high-flow nasal cannula (HFNC) has become an alternative to classical oxygenation techniques, although the results published for postoperative patients contradictory. We examined efficacy of HFNC morbidly obese who were ventilated intraoperatively with open-lung approach (OLA).METHODS: performed open, two-arm,...
Background: Acute respiratory distress syndrome (ARDS) is a complex, heterogeneous, and deadly condition often resulting from pulmonary lesions due to sepsis, among other causes. There lack of targeted therapies specifically treat the patients. Common genetic factors in population (frequency >1%) have been associated with ARDS susceptibility, but systematic screens role rare variants are lacking. We used network known molecular interactions identify risks clusters biologically related...
We conducted this study to test whether pulse-oximetry hemoglobin saturation (SpO2 ) can personalize the implementation of an open-lung approach during laparoscopy. Thirty patients with SpO2 ≥ 97% on room-air before anesthesia were studied. After and capnoperitoneum FIO2 was reduced 0.21. Those whose decreased below - indication shunt related atelectasis completed following phases: (1) First recruitment maneuver (RM), until reaching lung's opening pressure, defined as inspiratory pressure...