A5002866240- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Disease Management Strategies
- PI3K/AKT/mTOR signaling in cancer
- Genomics and Rare Diseases
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Helicobacter pylori-related gastroenterology studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mast cells and histamine
- Acute Myocardial Infarction Research
- Cancer Genomics and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Diabetes and associated disorders
- Cardiovascular Function and Risk Factors
- Pneumonia and Respiratory Infections
- Smoking Behavior and Cessation
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Autoimmune Bullous Skin Diseases
- Cardiac Imaging and Diagnostics
Universidad de La Laguna
2018-2025
Hospital Universitario Nuestra Señora de Candelaria
2015-2024
Hospital Universitario de Canarias
2020
Instituto de Salud Carlos III
2015-2017
Red de Investigación Cardiovascular
2015-2017
Background Irisin is a myokine that increases with leisure time physical activity (LTPA) and for which cardiovascular protective role has been postulated. Our aim was to assess this in the general population. Methods A cross-sectional analysis performed large randomly selected population sample (n=2298 women 1529 men). Apart from age sex, we record anthropometrics (blood pressure, heart rate, obesity), lifestyle (LTPA, smoking, alcohol), biochemical measurements (irisin, lipid profile,...
To analyse the association between serum C-peptide and coronary artery disease in general population.Follow-up study of 6630 adults from population. They were stratified into group 1 (no insulin resistance: < third tercile glycaemia 100 mg/dL), 2 (initial ⩾ mg/dL) 3 (advanced mg/dL).After 3.5 years follow-up, had a higher incidence myocardial infarction (relative risk (RR) = 4.2, 95% confidence interval (CI) 1.7-10.6) (RR 3.5, CI 1.9-6.6) than 1. Group also increased incidences both...
Aim Resistin is a cytokine related with inflammation and ischemic heart disease. Physical activity (PA) prevents chronic We studied the relationship of serum concentration resistin HDL cholesterol, known biomarker PA, different measures in large sample general adult population Canary Islands. Methods Cross-sectional study 6636 adults recruited randomly. analyzed correlation cholesterol PA (as metabolic equivalent level [MET]), fitted results linear logistic regression models using adjustment...
Despite the genetic resemblance of Canary Islanders to other southern European populations, their geographical isolation and historical admixture aborigines (from North Africa) with sub-Saharan Africans Europeans have shaped a distinctive makeup that likely affects disease susceptibility health disparities. Based on single nucleotide polymorphism array data whole genome sequencing (30×), we inferred last African took place ∼14 generations ago estimated up 34% Islander is recent descent. The...
Introduction Little is known on how the domain and intensity of physical activity (PA) associates with metabolic syndrome (MetS). The aim this study was to examine associations between PA domains (leisure-time, domestic, active transport, total walking PA), intensities (light, moderate vigorous) levels MetS in general adult population. Methods Cross-sectional study. Anthropometry, blood biochemistry, 79-item PA-questionnaire, lifestyle medical history were evaluated a representative sample...
Background and Objectives: One of the most common causes drug-induced angioedema (AE-DI) is related to reduced bradykinin breakdown after use certain medications. This case for forms AE-DI due angiotensin-converting enzyme inhibitors (ACEi), which are used treatment cardiovascular conditions. The AE not clear in these patients. Given limited number AE-ACEi genetic loci identified by genome-wide association studies, we opted assess utility NGS a panel relevant genes identify candidate risk...
Background: Acute respiratory distress syndrome (ARDS) is a complex, heterogeneous, and deadly condition often resulting from pulmonary lesions due to sepsis, among other causes. There lack of targeted therapies specifically treat the patients. Common genetic factors in population (frequency >1%) have been associated with ARDS susceptibility, but systematic screens role rare variants are lacking. We used network known molecular interactions identify risks clusters biologically related...
Abstract Background To analyze the trend of lower extremity major amputations (MA) among patients with type 2 diabetes mellitus (T2DM) in Regions Spain from year 2001 until 2015. Methods Descriptive study 40,392 MA. Data were obtained national hospital discharge database T2DM. The incidence rate was calculated each Region, addition to ratios (IR) between annual and 2001. length stay mortality risks analyzed using regression models adjusted for sex, age smoking. Results per 100,000...
Most causal variants of Mendelian diseases are exonic. Whole-exome sequencing (WES) has become the diagnostic gold standard, but causative variant prioritization constitutes a bottleneck. Here we assessed an in-house sample-to-sequence pipeline and benchmarked free tools for germline from WES data. 61 unselected patients with known genetic disease cause was obtained. Variant prioritizations were performed by diverse recorded to obtain yield when present in first, fifth, 10th top rankings. A...
Whole-exome sequencing has become a popular technique in research and clinical settings, assisting disease diagnosis increasing the understanding of pathogenesis. In this study, we aimed to compare common enrichment capture solutions available market. Peripheral blood-purified DNA samples were enriched with SureSelectQXT V6 (Agilent) various Illumina solutions: TruSeq Nano, Exome, Nextera Prep Enrichment, sequenced on HiSeq 4000. We found that their percentage duplicate reads was as much 2...
Acute respiratory distress syndrome (ARDS) is an inflammatory process of the lungs that develops primarily in response to pulmonary or systemic sepsis, resulting a disproportionate death toll intensive care units (ICUs). Given its role as critical activator and innate immune responses, previous studies have reported increase circulating cell-free mitochondrial DNA (mtDNA) biomarker for fatal outcome ICU. Here we analyzed association whole-blood mtDNA (wb-mtDNA) copies with 28-day survival...
To determine whether the risk of cardiovascular mortality associated with cardiorenal syndrome subtype 1 (CRS1) in patients who were hospitalized for acute coronary (ACS) was greater than expected based on sum its components, to estimate predictive value CRS1, and severity CRS1 worsens prognosis.Follow-up study 1912 incident cases ACS year after discharge. Cox regression models estimated time event (in-hospital death, readmission or death during first discharge) as dependent variable.The...
The prevalence of asthma symptoms in Canary Islanders, a southwestern European population from Spain, is almost three times higher than the country average. Because genetic risks identified so far explain <5% heritability, here we aimed to discover new loci by completing first admixture mapping study Islanders leveraging their distinctive makeup, where significant northwest African influences coexist diversity landscape. A 2-stage was conducted 1,491 unrelated individuals self-declaring...
Accurate and complete de novo assembled genomes sustain variant identification catalyze the discovery of new genomic features biological functions. However, accurate precise assemblies large complex remains a challenging task. Long-read sequencing data alone or in hybrid mode combined with more short-read sequences facilitate assembly genomes. A number software exists for genome from long-read although specific performance comparisons to human are lacking. Here we benchmarked 11 different...
A shared genetic component between coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) has been described based on analyses of individual risk variants. Here we used a whole-genome polygenic score (PRS) approach to further evaluate age- sex-stratified overlap IPF severe COVID-19 give insight into biological mechanisms that might both inform therapeutic strategies for diseases. We results from the largest genome-wide association study clinically defined (4125 cases/20...
Irisin is a myokine with potential role in cardiometabolic diseases, but previous studies have described inconsistencies between serum irisin and physical activity (PA). Our aim was to analyze the relationship leisure-time PA (LTPA) large sample of general adult population, secondarily, evaluate its two PA-related biomarkers (HDL cholesterol resistin).A cross-sectional study nested "CDC Canary Islands" cohort participants (n = 3827, 18-75 years, 60% women).PA collected by administering...
Background Hereditary angioedema is a rare genetic condition caused by C1 esterase inhibitor deficiency, dysfunction, or kinin cascade dysregulation, leading to an increased bradykinin plasma concentration. poorly recognized clinical entity and very often misdiagnosed as histaminergic angioedema. Despite its nature, first-line screening not integrated in routine diagnosis. Consequently, delay the diagnosis, inaccurate incomplete diagnosis treatment of hereditary are common. Objective In...