A5050853910- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Biomedical Ethics and Regulation
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- Mast cells and histamine
- Cytomegalovirus and herpesvirus research
- Asthma and respiratory diseases
- Electrospun Nanofibers in Biomedical Applications
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Knee injuries and reconstruction techniques
- Bone Tissue Engineering Materials
- Biosimilars and Bioanalytical Methods
- Pancreatic function and diabetes
- Bone health and treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Wound Healing and Treatments
- Food Allergy and Anaphylaxis Research
Banc de Sang i Teixits
2013-2020
Weatherford College
2020
Universitat de Barcelona
2008-2011
Instituto de Salud Carlos III
2011
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2008
Only 30% of embryos from in vitro fertilized oocytes successfully implant and develop to term, leading repeated transfer cycles. To reduce time-to-pregnancy stress for patients, there is a need diagnostic tool better select based on their physiology. The current standard employs brightfield imaging, which provides limited physiological information. Here, we introduce METAPHOR: Metabolic Evaluation through Phasor-based Hyperspectral Imaging Organelle Recognition. This non-invasive, label-free...
Abstract CD84 is a self-binding receptor from the CD150 (or signaling lymphocyte activation molecule [SLAM]) family that broadly expressed in hematopoietic cells. It has been described adaptors SLAM-associated protein (SAP) and EWS-FLI1–activated transcript 2 (EAT-2) are critical for members’ function. We observed human mast cells express but lack SAP or EAT-2, tyrosine phosphorylated upon FcεRI engagement, release of granule contents reduced when coengaged with LAD2 CD34+-derived In...
Abstract In the field of orthopedics, translational research novel therapeutic approaches involves use large animal models (such as sheep, goat, pig, dog, and horse) due to similarities with humans in weight, size, joint structure, bone/cartilage healing mechanisms. Particularly development cell‐based therapies, lack manageable immunocompromised preclinical prevents human cells, which makes it necessary produce equivalent homologous cell types for study their pharmacodynamics,...
Pseudoarthrosis is a relatively frequent complication of fractures, in which the lack mechanical stability and biological stimuli results failure bone union, most frequently humerus tibia. Treatment recalcitrant pseudoarthrosis relies on achievement satisfactory combined with adequate local biology. Herein we present two cases atrophic that received tissue-engineering product (TEP) composed autologous marrow-derived mesenchymal stromal cells (BM-MSC) deantigenized trabecular particles from...
Immunosuppressed patients are susceptible to virus reactivation or de novo infection. Adoptive immunotherapy, based on virus-specific T lymphocytes (VST), can prevent treat viral diseases. However, donor availability, HLA-compatibility restrictions, high costs and time required for the production of personalized medicines constitute considerable limitations this treatment. Ex vivo rapid large-scale expansion VST, compliant with current good manufacturing practice (cGMP) standards, an...
Background Academic institutions and transfusion centres are positioned to lead the development of novel cell-based therapeutics up early-stage clinical trials (and further seeking marketing authorisation) or, alternatively, its use under hospital exemption clause [1,2]. Existing structures, including blood tissue bank facilities, translational medical programs skilled personnel experienced in cell culture technologies transplantation, equips these non-commercial entities translate...
Background Gonarthrosis is the most common cause of pain and disability in middle-aged elderly people [1,2]. The lack long-lasting effective treatments for repairing degenerated articular cartilage has spurred research into novel cell-based therapies aiming at reducing pain, slowing degeneration and, ultimately, reverting natural history osteoarthritis (OA) [3]. Herein we report development a mesenchymal stromal cell (MSC)-based therapy, from conception up to completion Phase I/IIa...
Background Transfusion of red blood cells (RBC) is the only clinically effective therapeutic approach for treating oxygen transport deficits (i.e. loss in surgical interventions and anaemia). However potential shortage transfusable RBC has been predicted near future as a result an imbalance between supply demand due to aging population, increase transmission infectious diseases, limited compatibility stored stocks, requirement rare groups [1,2]. This situation direct impact Public Health it...
Computerized systems (CS) are essential in the development and manufacture of cell-based medicines must comply with good manufacturing practice, thus pushing academic developers to implement methods that typically found within pharmaceutical industry environments.Qualitative quantitative risk analyses were performed by Ishikawa Failure Mode Effects Analysis, respectively.A process for qualification a CS keeps track environmental conditions was designed executed. The simplicity analysis...
Background Human Mesenchymal Stromal Cells (MSC) are multipotent cells residing in all support and structural tissues of the organism they capable extensive expansion vitro while preserving their identity, potency genetic stability [1]. Umbilical cord (UC)-derived MSC (UC-MSC) thought to be more primitive progenitor than those isolated from bone marrow or lipoaspirates [2]. The fact that umbilical is a waste tissue an added value isolation UC-MSC this source for generation cell banks later...