A5003561217- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Sinusitis and nasal conditions
- Inflammatory mediators and NSAID effects
- Drug-Induced Adverse Reactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mast cells and histamine
- Inhalation and Respiratory Drug Delivery
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Nasal Surgery and Airway Studies
- Olfactory and Sensory Function Studies
- IL-33, ST2, and ILC Pathways
- Cystic Fibrosis Research Advances
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Obstructive Sleep Apnea Research
- Contact Dermatitis and Allergies
- Eosinophilic Esophagitis
- Neuroscience of respiration and sleep
Universitat de Barcelona
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025
Hospital Clínic de Barcelona
2014-2023
Instituto de Salud Carlos III
2011-2023
Centre for Biomedical Network Research on Rare Diseases
2009-2023
Biomedical Research Institute
2023
Centro de Investigación Biomédica en Red
2008-2021
Departament de Salut
2021
Centro de Investigación en Red en Enfermedades Cardiovasculares
2019-2020
Leukotriene antagonists block the proinflammatory actions of leukotrienes (LT) and have been introduced as new treatments for asthma. Conventional therapy with glucocorticosteroids does not inhibit biosynthesis leukotrienes. We therefore tested whether addition leukotriene receptor antagonist montelukast was therapeutic benefit in a group aspirin-intolerant patients asthma whom 90% already were treated moderate to high doses glucocorticosteroids. Under double-blind conditions, 80 randomized...
BACKGROUND: Reduced bone mass predisposes patients to the development of vertebral fractures. Measurement by non-invasive methods is used detect with involutional osteoporosis at risk from These have not been assessed in steroid dependent osteoporosis. The objective this study was assess value a predictive fracture threshold density asthma. METHODS: Three groups were studied. Group 1 (67 patients) had asthma (mean daily dose prednisone 11.7 mg) and no fractures, group 2 (32 12 3 (55 taking...
Exogenous prostaglandin E2 (PGE2) given by inhalation almost completely abrogates aspirin-induced asthma and the accompanying increase in cysteinyl-leukotrienes production. Cyclooxygenase (COX) may be present cells both constitutive (COX-1) inducible (COX-2) forms. To production of potentially protective endogenous PGE2, COX-2 should upregulated. We hypothesize that an abnormal regulation will predispose patients with to develop aspirin-intolerant asthma/rhinitis (AIAR). therefore examined...
Alternative splicing of the human glucocorticoid receptor (GR) primary transcript generates two protein isoforms: GR-α and GR-β. We investigated expression both GR isoforms in healthy cells tissues. mRNA abundance (×10 6 cDNA copies/μg total RNA) was as follows: brain (3.83 ± 0.80) > skeletal muscle macrophages lung kidney liver heart eosinophils peripheral blood mononuclear (PBMCs) nasal mucosa neutrophils colon (0.33 0.04). GR-β much less expressed than mRNA. Its 3 (1.55 0.58) PBMCs ≥...
Background: Nasal polyposis (NP) is not a life‐threatening disorder but may have great impact on the quality of life (QoL). The objective this study: (i) to investigate health burden incurred by NP compared with Spanish general population using Short Form‐36 Health Survey (SF‐36) questionnaire; (ii) compare QoL outcome after medical or surgical treatment; and (iii) assess effect treatment nasal symptoms. Methods: About 109 patients polyps were included. Fifty‐three randomly allocated receive...
To investigate olfaction in general population, prevalence of olfactory dysfunction and related risk factors.Cross-sectional population-based survey, distributing four microencapsulated odorants (rose, banana, musk gas) two self-administered questionnaires (odour description; epidemiology/health status).The survey was distributed to population through a bilingual (Catalan, Spanish) newspaper Catalonia (Spain), on December 2003.Newspaper readers all ages gender; 9348 surveys were analysed...
Multiple plant-food sensitizations with a complex pattern of clinical manifestations are common feature lipid transfer protein (LTP)-allergic patients. Component-resolved diagnosis permits the allergen sensitization profile.We sought to clinically characterize and describe pollen molecular profile in patients LTP syndrome.Forty-five subjects were recruited, after being diagnosed multiple allergies sensitized LTP, but not any other allergen, according panel tested (Pru p 3 (LTP), Pru 1 (Bet v...
Objective: Validation of the Spanish version Asthma Control Test (ACT). Methods: A total 607 asthmatic patients were assessed. The psychometric properties ACT evaluated. capacity to predict physician's assessment asthma control was assessed using area under receiving operating characteristics (ROC) curve (AUC), sensitivity, specificity, and positive-negative predictive values. Results: ACT's Cronbach α 0.84. intraclass correlation coefficient 0.85. AUC 0.86, with a sensitivity 71%...
Aim. To evaluate the effectiveness of omalizumab in non-atopic asthma. Methods. Using data from a multicenter registry severe asthma, we evaluated and compared clinical outcome 29 omalizumab-treated asthmatics with 266 allergic asthmatics. Effectiveness was assessed by considering exacerbations, pulmonary function, Global Evaluation Treatment (GETE) scale, Asthma Control Test (ACT). Results. Omalizumab demonstrated significant improvement status as measured GETE, which rose 1.6 ± 1.1 to 2.8...
Abstract Background Continuous positive airway pressure ( CPAP ) in asthma patients with concomitant obstructive sleep apnea syndrome OSAS seems to have a favorable impact on asthma, but data are inconsistent due methodological limitations of previous studies. Methods Prospective, multicenter study. We examined outcomes after 6 months 99 adult (mean age 57 years) (respiratory disturbance index ≥20). Asthma control and quality life were assessed the Control Questionnaire ACQ Mini Quality Life...
About one-tenth of patients with difficult-to-treat chronic rhinosinusitis nasal polyps (CRSwNP) have comorbid non-steroidal anti-inflammatory drug-exacerbated respiratory disease (NSAID-ERD). Dupilumab, a fully human monoclonal antibody that blocks the shared interleukin (IL)-4/IL-13 receptor component, is an approved add-on treatment in severe CRSwNP. This post hoc analysis evaluated dupilumab efficacy and safety CRSwNP with/without NSAID-ERD.Data were pooled from phase 3 SINUS-24 SINUS-52...
Transforming growth factor-beta1 (TGF-beta1) is a cytokine that plays key role in the development of idiopathic pulmonary fibrosis. There have been reports on presence two genetic polymorphisms DNA sequence encoding leader TGF-beta1 protein, located codons 10 and 25. The objective this study was to investigate association between gene 25 susceptibility fibrosis progression disease. Compared with healthy control subjects (n = 140), patients 128) showed no significant deviations genotype or...
Although the mechanism of aspirin-induced asthma and rhinitis is unknown, it has been suggested that adverse nasal bronchial reactions are caused by an increased production lipoxygenase products. In examining this hypothesis we have measured release peptide leukotrienes (PeptLTs), 15-HETE, prostaglandins in fluids obtained lavages after instillation acetylsalycilic acid (ASA) placebo (saline). Ten ASA-sensitive asthmatics, 10 ASA-insensitive seven healthy subjects were challenged a...
Abstract Objectives/Hypothesis: A degree of smell disturbance has been found in seasonal and perennial allergic rhinitis, but alterations olfaction patients with persistent rhinitis (PER) have not yet evaluated. The aims the study were to evaluate impact PER on sense smell, characterize this based self‐reported hyposmia (SRH) severity. Study Design/Methods: prospective controlled was performed 49 consecutive PER. subclassified depending severity presence SRH. Olfactory function evaluated by...
The efficacy of omalizumab in severe asthma has been widely demonstrated. main objective this study was to evaluate the and tolerability a real-life setting Spain, particularly those patients with immunoglobulin E (IgE) levels out range.Totally 266 uncontrolled receiving high-dose inhaled corticosteroids (ICSs) plus long-acting β2-agonist (LABA) were recruited. Main outcomes exacerbation rate (AER), control test (ACT), global evaluation treatment effectiveness (GETE).AER reduced from 3.6...
Clinical Implications•This study aimed to determine the rate of severe acute respiratory syndrome coronavirus 2 infection in Spanish patients with asthma under biological treatment and examine whether rates severity differ among several antiasthma drugs between without biologicals. With data from this cohort, we hypothesize that for uncontrolled does not represent a risk factor disease 2019 or its there are no significant differences different biologic used. •This On March 11, 2020, World...