A5100329253- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- Receptor Mechanisms and Signaling
- Ubiquitin and proteasome pathways
- Single-cell and spatial transcriptomics
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Genomics and Chromatin Dynamics
- Neuropeptides and Animal Physiology
- Ginseng Biological Effects and Applications
- Asthma and respiratory diseases
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Respiratory and Cough-Related Research
- Erythrocyte Function and Pathophysiology
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Gestational Diabetes Research and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacological Effects of Natural Compounds
- Endoplasmic Reticulum Stress and Disease
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2024
University of Electronic Science and Technology of China
2021-2024
Affiliated Hospital of Southwest Medical University
2024
Huaiyin Normal University
2019-2024
First Affiliated Hospital of University of South China
2023
University of South China
2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
Leukotriene antagonists block the proinflammatory actions of leukotrienes (LT) and have been introduced as new treatments for asthma. Conventional therapy with glucocorticosteroids does not inhibit biosynthesis leukotrienes. We therefore tested whether addition leukotriene receptor antagonist montelukast was therapeutic benefit in a group aspirin-intolerant patients asthma whom 90% already were treated moderate to high doses glucocorticosteroids. Under double-blind conditions, 80 randomized...
SummaryAutophagy, the primary recycling pathway of cells, plays a critical role in mitochondrial quality control under normal growth conditions and response to cellular stress. The Hsp90-Cdc37 chaperone complex coordinately regulates activity select kinases orchestrate many facets stress response. Although both maintain integrity, relationship between autophagy has not been well characterized. Ulk1, one mammalian homologs yeast Atg1, is serine-threonine kinase required for mitophagy. Here we...
Postischemic angiogenesis is critical to limit the ischemic tissue damage and improve blood flow recovery. The regulation underlying molecular mechanisms of postischemic are not fully unraveled. TFEB (transcription factor EB) emerging as a master gene for autophagy lysosome biogenesis. However, role in vascular disease less understood.We aimed determine endothelial its mechanism.In primary human cells (ECs), serum starvation induced nuclear translocation. VEGF (vascular growth factor)...
Occurrence and development of cancers are governed by complex networks interacting intercellular intracellular signals. The technology single-cell RNA sequencing (scRNA-seq) provides an unprecedented opportunity for dissecting the interplay between cancer cells associated microenvironment. Here we combined scRNA-seq data with clinical bulk gene expression to develop a computational pipeline identifying prognostic predictive signature that connects microenvironmental cells. was applied glioma...
Elimination of defective mitochondria is essential for the health long-lived, postmitotic cells. To gain insight into this process, we examined programmed mitochondrial clearance in reticulocytes. BNIP3L a outer membrane protein that required clearance. It has been suggested functions by causing depolarization, activating autophagy, or engaging autophagy machinery. Here showed mice activity localizes to small region its cytoplasmic domain, minimal (MER). The MER novel sequence, which...
Oral tongue squamous cell carcinoma (OTSCC) is still associated with a poor prognosis due to local recurrence and metastasis. Cancer-associated fibroblasts (CAFs) play an important role in the complex processes of cancer stroma interaction tumorigenesis. This study aims determine CAFs development progression OTSCC.Immunohistochemistry was performed evaluate frequency distribution 178 paraffin specimens from patients OTSCC. Immunofluorescence, proliferation assay, flow cytometry, migration...
ABSTRACT Aim To examine the prevalence and predictors of physical inactivity among pregnant women at high risk for gestational diabetes mellitus (GDM) in mainland China. Methods A cross‐sectional study was implemented Zhengzhou, China from October 2021 to February 2022. Two hundred fifty‐two GDM were recruited. Physical assessed by Pregnancy Activity Questionnaire. The Self‐Efficacy Scale, Knowledge Questionnaire, Social Support 7‐item Generalized Anxiety Disorder Edinburgh Postnatal...
Abstract To assess the validity of rodent models for investigating role delta opioid receptors (DOR) in analgesia, distribution DOR binding and mRNA were compared between primate spinal cord dorsal root ganglia (DRG), using receptor autoradiography situ hybridization, respectively. In mouse rat cord, [ 125 I]‐deltorphin‐labeled sites detected throughout gray matter. contrast, particularly human was mainly present laminae I–II, with little to no deeper layers. Accordingly, expressed by a...
Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding family, responsible for transportation fatty acids. It considered to express mainly in adipose tissues, and be strongly associated with inflammation, obesity, diabetes cardiovasculardiseases. Here we report that FABP4 also expressed cardiomyocytes plays an important role regulating heart function under pressure overload. We generated heart-specific transgenic (FABP4-TG) mice using α myosin-heavy chain (α-MHC)...
E2F transcription factors are associated with the development of cancer. However, family genes have not yet been studied in a comprehensive manner. Using The Cancer Genome Atlas, present study analyzed functions across different types tumor. It was revealed that compared normal tissues, highly expressed several tumor tissue. Furthermore, were significantly enriched samples high expression levels an unfavorable prognosis liver hepatocellular carcinoma (LIHC) and lung adenocarcinoma (LUAD)....
Altered glial function that leads to oxidative stress and excitotoxicity may contribute the initiation or progression of neuronal death in neurodegenerative diseases. We report pivotal role astroglial Group II III metabotropic glutamate receptors (mGluR) against neurotoxicity. Activation mGluR on astrocytes with selective agonists DCG-IV L-AP4 respectively inhibited lipopolysaccharide (LPS)-conditioned medium induced apoptosis primary cultured mesencephalic neurons. Specific antagonists...
Estrogen receptor α (ERα) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcriptional events that promote tumor growth. ERα activity largely depends on access sites chromatin, which is facilitated part Pioneer Factors (PFs). Transcription factors operate complexes through thousands genomic a combinatorial fashion control expression genes. However, extent crosstalk cooperation between pioneer more collaborative transcription cancer...
Although extensive investigation has revealed that an astrocyte-specific protein aquaporin-4 (AQP4) participates in regulating synaptic plasticity and memory, a functional relationship between AQP4 learning processing not been clearly established. This study was designed to test our hypothesis modulates the aversive motivation Morris water maze (MWM).Using hidden platform training, we observed KO mice significantly decreased their swimming velocity compared with wild-type (WT) mice. To for...
Eye diseases are remarkably common and encompass a large diverse range of morbidities that affect different components the visual system function. With advances in omics technology eye disorders, genome-scale datasets have been rapidly accumulated genetics epigenetics field. However, efficient collection comprehensive analysis kinds data lacking. Herein, we developed
Abstract Based on isocitrate dehydrogenase (IDH) alterations, lower grade glioma (LGG) is divided into IDH mutant and wild type subgroups. However, the further classification of LGG was unclear. Here, patients in The Cancer Genome Atlas Chinese Glioma were two sub-clusters using non-negative matrix factorization. sub-cluster2 had prolonged overall survival low frequency CDKN2A alterations immune infiltrations. Differentially expressed genes sub-cluster1 positively correlated with RUNX1...
Elevated expression of human epididymis protein 4 (HE4) was previously described in connective tissue disease-associated interstitial lung diseases (CTD-ILDs) and cystic fibrosis (CF), but the clinical significance HE4 has remained unknown idiopathic pulmonary (IPF), which is a progressive fibrosing ILD with heterogeneous course that urgent need reliable biomarkers its practice.A total 27 IPF patients acute exacerbation status (AE-IPF), 32 stable (S-IPF), 29 sex-age matched healthy controls...
Objective Alzheimer’s disease (AD) as the most frequent neurodegenerative is featured by gradual decline of cognition and social function in elderly. However, there have been few studies focusing on AD heterogeneity which exists both genetically clinically, leading to difficulties researches. As one major kind clinical heterogeneity, lifespan patients varies significantly. Aiming investigate potential driving factors, current research identified differentially expressed genes (DEGs) between...