A5077648137- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nanoplatforms for cancer theranostics
- Protein Structure and Dynamics
- Machine Learning in Bioinformatics
- Supramolecular Self-Assembly in Materials
- Inflammatory Myopathies and Dermatomyositis
- Enzyme Structure and Function
- Nanoparticle-Based Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Skin Diseases and Diabetes
- Sarcoidosis and Beryllium Toxicity Research
- CAR-T cell therapy research
- Occupational and environmental lung diseases
- Eosinophilic Disorders and Syndromes
- Systemic Sclerosis and Related Diseases
- Polydiacetylene-based materials and applications
- Liver Disease Diagnosis and Treatment
- Gyrotron and Vacuum Electronics Research
- Plasma Applications and Diagnostics
- Advanced biosensing and bioanalysis techniques
Nanjing Drum Tower Hospital
2015-2025
National Center for Nanoscience and Technology
2013-2024
University of Chinese Academy of Sciences
2019-2024
Chinese Research Academy of Environmental Sciences
2024
First Affiliated Hospital of Harbin Medical University
2024
China Pharmaceutical University
2024
Harbin Medical University
2024
Weatherford College
2023
BeiGene (China)
2020-2022
National Institute of Metrology
2021
The morphology controlled molecular assemblies play vital roles in biological systems. Here we present endogenous reactive oxygen species (ROS)-triggered transformation of polymer-peptide conjugates (PPCs) for cooperative interaction with mitochondria, exhibiting high tumor therapeutic efficacy. PPCs are composed (i) a β-sheet-forming peptide KLVFF conjugated poly(ethylene glycol) through ROS-cleavable thioketal, (ii) mitochondria-targeting cytotoxic KLAK, and (iii) poly(vinyl alcohol)...
Tumor metastasis is one of the big challenges in cancer treatment and often associated with high patient mortality. Until now, there an agreement that tumor invasion are related to degradation extracellular matrix (ECM) by enzymes. Inspired formation natural ECM situ self-assembly strategy developed our group, herein, we constructed artificial (AECM) based on transformable Laminin (LN)-mimic peptide 1 (BP-KLVFFK-GGDGR-YIGSR) for inhibition metastasis. The was composed three modules including...
In cancer treatment, the unsatisfactory solid-tumor penetration of nanomaterials limits their therapeutic efficacy. We employed an in vivo self-assembly strategy and designed polymer–peptide conjugates (PPCs) that underwent acid-induced hydrophobicity increase with a narrow pH-response range (from 7.4 to 6.5). situ tumor microenvironment at appropriate molecular concentrations (around IC50 values PPCs) enabled drug delivery deeper into tumor. A cytotoxic peptide KLAK, decorated pH-sensitive...
A pathology-adaptive nanosystem, in which nest-like hosts are built based on nanofibers that transformed from i.v. injected nanoparticles under the acidic tumor microenvironment. The solid is artificially modified by readily and firmly, resulting highly efficient accumulation stabilization of guest theranostics. This strategy shows great potential for theranostics delivery to tumors.
Background Tislelizumab is an investigational, humanized, IgG4 monoclonal antibody with high affinity and binding specificity for programmed cell death-1 (PD-1) that was engineered to minimize FcγR on macrophages in order abrogate antibody-dependent phagocytosis, a mechanism of T-cell clearance potential resistance anti-PD-1 therapy. Methods The purpose this phase 1/2, open-label, non-comparative study examine the safety, tolerability, antitumor activity tislelizumab adult (≥18 years)...
The precise and highly efficient drug delivery of nanomedicines into lesions remains a critical challenge in clinical translational research. Here, an autocatalytic morphology transformation platform is presented for improving the tumor-specific accumulation drugs by kinetic control. situ reorganization prodrug from nanoparticle to β-sheet fibrous structures targeted based on nucleation-based growth kinetics. During multiple administrations, can be realized skipping slow nucleating process...
Photodynamic therapy is widely used in clinics and for anti-bacterial applications. The major challenge the limited depth of tissue penetration light poor targetability. In this study, magnetite nanoparticles were as a highly sensitive T2-weighted MR imaging contrast agents to target tumor mimic horseradish peroxidase (HRP), which could catalyze decomposition hydrogen peroxide generate reactive oxygen species (ROS) inhibit vivo. these experiments, MNPs demonstrated possess enzyme-mimicking...
Here a near-infrared light and pH responsive nanocomposite comprising spiropyran-functionalized amphiphilic polymers upconversion nanoparticles (UCNPs) is reported, which prepared through the self-assembly of encapsulation UCNPs in core self-assemblies. Upon irradiation, fluorescence can induce hydrophobic spiropyran to be isomerized hydrophilic merocyanine disrupt spherical morphology nanocomposites. Meanwhile, at low pH, also protonated become merocyanine, self-assemblies are swollen....
Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF characterized by excessive accumulation of the extracellular matrix (ECM) in alveolar parenchyma and progressive lung scarring. The pathogenesis whether ECM involved process remain unknown.To identify potential treatment target associated proteins that may be development IPF, we employed isobaric tag for relative absolute quantitation (iTRAQ) combined liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a type of chronic interstitial pneumonia, often fatal, with elusive causes and bleak prognosis. Its treatment options are limited largely ineffective. Early detection precise diagnosis pivotal in managing the disease effectively enhancing patient survival rates. Recently, quest for trustworthy biomarkers IPF has gained momentum. Notably, emerging studies indicate that circular RNAs (circRNAs) found exosomes may hold significant...
Various nanomaterials have been demonstrated as autophagy inducers owing to their endocytosis cell uptake pathway and impairment of lysosomes. pH-dependent drug delivery systems that are capable dissociating in weakly acidic lysosomal environment (pH 4–5) consequently releasing the payloads into cytoplasm paid extensive attention, but autophagy-modulating effects less reported so far. In this study, we report pH-sensitive micelle-like nanoparticles (NPs) self-assembled from poly(β-amino...
Protein dihedral angles provide a detailed description of protein local conformation. Predicted can be used to narrow down the conformational space whole polypeptide chain significantly, thus aiding tertiary structure prediction. However, direct angle prediction from sequence alone is challenging. In this article, we present novel method (named RaptorX-Angle) predict real-valued by combining clustering and deep learning. Tested on subset PDB25 targets in latest two Critical Assessment...
We report an assembly and transformation process of a supramolecular module, BP-KLVFF-RGD (BKR) in solution on specific living cell surfaces for imaging treatment. The BKR self-assembled into nanoparticles, which further transformed nanofibers situ induced by coordination with Ca2+ ions.
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease with poor prognosis. The mechanisms underlying the role of alveolar epithelial cell (AEC) senescence in IPF remain poorly understood. We aimed to investigate if PTEN/Akt activates AEC induce fibrosis. investigated association between and cellular lung tissues from patients. As a result, decreased PTEN activated Akt pathway were found AECs fibrotic detected by immunohistochemistry (IHC) immunofluorescence (IF). Increased...
Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, only method for PCO treatment precisely focused laser However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) reported, in which rim of commercially available IOLs (C-IOLs) decorated with silica coated Au nanorods (Au@SiO2 ), high-efficient prevention The Nano-IOLs capable...
Abstract In cancer treatment, the unsatisfactory solid‐tumor penetration of nanomaterials limits their therapeutic efficacy. We employed an in vivo self‐assembly strategy and designed polymer–peptide conjugates (PPCs) that underwent acid‐induced hydrophobicity increase with a narrow pH‐response range (from 7.4 to 6.5). situ tumor microenvironment at appropriate molecular concentrations (around IC 50 values PPCs) enabled drug delivery deeper into tumor. A cytotoxic peptide KLAK, decorated...
Patients with antimelanoma differentiation-associated gene 5 antibody-positive dermatomyositis-associated interstitial lung disease (anti-MDA5+DM-ILD) are susceptible to rapidly progressive (RP-ILD) and have a high risk of mortality. There is an urgent need for reliable prediction model, accessible via easy-to-use web-based tool, evaluate the death. This study aimed develop validate model 3-month mortality using machine learning (ML) in large multicenter cohort patients anti-MDA5+DM-ILD...
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