A5030120484- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Dendrimers and Hyperbranched Polymers
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Bladder and Urothelial Cancer Treatments
- Photodynamic Therapy Research Studies
- Advanced Polymer Synthesis and Characterization
- RNA modifications and cancer
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Polymer Surface Interaction Studies
- Tissue Engineering and Regenerative Medicine
- Nanocluster Synthesis and Applications
- Peptidase Inhibition and Analysis
- Genomics, phytochemicals, and oxidative stress
- Boron Compounds in Chemistry
- Moringa oleifera research and applications
- Polydiacetylene-based materials and applications
- Medicinal Plants and Bioactive Compounds
Wuhan University of Technology
2020-2025
National Center for Nanoscience and Technology
2017-2022
University of Chinese Academy of Sciences
2019
Chinese Academy of Sciences
2018
Taisei (Japan)
2018
Nanomaterials Research (United States)
2017
Center for NanoScience
2017
Wuhan University
2015-2016
National Research Center for Rehabilitation Technical Aids
2015
South China University of Technology
2015
The use of nanoparticles as a potential building block for photosensitizers has recently become focus interest in the field photocatalysis and photodynamic therapy. Porphyrins their derivatives are effective due to extended π-conjugated electronic structure, high molar absorption from visible near-infrared spectrum, singlet oxygen quantum yields well chemical versatility. In this paper, we report synthesis self-assembled porphyrin nanoparticle using zinc meso-tetra(4-pyridyl)porphyrin...
Functional mesoporous silica particles have attracted growing research interest for controlled drug delivery in targeted cancer therapy. For the purpose of efficient targeting tumor cells and reducing adverse effect antitumor doxorubicin (DOX), biocompatible enzyme-responsive nanoparticles (MSNs) with specificity were desired. To construct these functional MSNs, classic rotaxane structure formed between alkoxysilane tether α-cyclodextrin (α-CD) was employed to anchor onto orifices MSNs as...
The morphology controlled molecular assemblies play vital roles in biological systems. Here we present endogenous reactive oxygen species (ROS)-triggered transformation of polymer-peptide conjugates (PPCs) for cooperative interaction with mitochondria, exhibiting high tumor therapeutic efficacy. PPCs are composed (i) a β-sheet-forming peptide KLVFF conjugated poly(ethylene glycol) through ROS-cleavable thioketal, (ii) mitochondria-targeting cytotoxic KLAK, and (iii) poly(vinyl alcohol)...
In cancer treatment, the unsatisfactory solid-tumor penetration of nanomaterials limits their therapeutic efficacy. We employed an in vivo self-assembly strategy and designed polymer–peptide conjugates (PPCs) that underwent acid-induced hydrophobicity increase with a narrow pH-response range (from 7.4 to 6.5). situ tumor microenvironment at appropriate molecular concentrations (around IC50 values PPCs) enabled drug delivery deeper into tumor. A cytotoxic peptide KLAK, decorated pH-sensitive...
Abstract Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4 (GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However, wide application GPX4 in therapy is hampered due to poor delivery efficacy and nonspecific ferroptosis. Taking advantage vivo self-assembly, we develop peptide-ferriporphyrin conjugate with microenvironment specific improve penetration, endocytosis inhibition, ultimately enhancing its anticancer activity...
The precise and highly efficient drug delivery of nanomedicines into lesions remains a critical challenge in clinical translational research. Here, an autocatalytic morphology transformation platform is presented for improving the tumor-specific accumulation drugs by kinetic control. situ reorganization prodrug from nanoparticle to β-sheet fibrous structures targeted based on nucleation-based growth kinetics. During multiple administrations, can be realized skipping slow nucleating process...
The shape of a drug delivery system impacts its in vivo behavior such as circulation time, accumulation, and penetration. Considering the advantages functional dyes bioapplications, we synthesize class nanoaggregates based on BF2-azadipyrromethene (aza-BODIPY) dyes, which can realize long blood deep tumor penetration simultaneously through morphological transformation modulated by near-infrared (NIR) laser. First, when temperature increases, wormlike nanofibers aza-BODIPY-1 aggregate,...
Platelets play a critical role in the regulation of coagulation, one essential processes life, attracting great attention. However, mimicking platelets for vivo artificial coagulation is still challenge due to complexity process. Here, we design platelet-like nanoparticles (pNPs) based on self-assembled peptides that initiate and form clots blood vessels. The pNPs first bind specifically membrane glycoprotein (i.e., CD105) overexpressed angiogenetic endothelial cells tumor site...
Abstract Intravesical administration of first‐line drugs has shown failure in the treatment bladder cancer owing to poor tumor retention time chemotherapeutics. Herein, we report an intracellular hydrolytic condensation ( IHC ) system construct long‐term retentive nano‐drug depots situ, wherein sustained drug release results highly efficient suppression cancer. Briefly, designed doxorubicin (Dox)‐silane conjugates self‐assemble into silane‐based prodrug nanoparticles, which condense silicon...
The in situ construction of the nanoassembly has been demonstrated to improve performance bioactive molecules, but control morphology nanomaterials vivo still remains a tremendous challenge. Herein, photothermal-promoted transformation (PMT) strategy is developed accelerate formation for improving biological drug molecules. Compared with spontaneous process, rate increases by ∼4 times PMT process. Owing increased assembly rate, tumor accumulation drugs ∼2-fold than that without photo...
ABSTRACT Mitochondriopathy inspired adenosine triphosphate (ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains prodigious challenge. Harnessing the advantages in vivo self-assembled nanomaterials, we designed an Intracellular Sequestration (IAS) system to specifically construct nanofibrous nanostructures on surface nuclei with exposed binding sites,...
Lysosome-targeting self-assembling prodrugs had emerged as an attractive approach to overcome the acquisition of resistance chemotherapeutics by inhibiting lysosomal sequestration. Taking advantage acidification induced intracellular hydrolytic condensation, we developed a lysosomal-targeting self-condensation prodrug-nanoplatform (LTSPN) system for overcoming lysosome-mediated drug resistance. Briefly, designed hydroxycamptothecine (HCPT)-silane conjugates self-assembled into silane-based...
Nanoparticles as drug-delivery systems have received significant attention due to their merits such prolonged circulation time and passive targeting of a tumor site.
The stimuli-responsive polymeric nanocarriers have been studied extensively, and their structural changes in cells are important for the controlled intracellular drug release. present work reported RGD-dextran/purpurin 18 conjugates with pH-responsive phenylboronate as spacer monitoring change of nanovehicles through ratiometric photoacoustic (PA) signal. Phenylboronic acid modified purpurin (NPBA-P18) could attach onto RGD-decorated dextran (RGD-Dex), resulting RGD-Dex/NPBA-P18 (RDNP)...
Abstract In cancer treatment, the unsatisfactory solid‐tumor penetration of nanomaterials limits their therapeutic efficacy. We employed an in vivo self‐assembly strategy and designed polymer–peptide conjugates (PPCs) that underwent acid‐induced hydrophobicity increase with a narrow pH‐response range (from 7.4 to 6.5). situ tumor microenvironment at appropriate molecular concentrations (around IC 50 values PPCs) enabled drug delivery deeper into tumor. A cytotoxic peptide KLAK, decorated...
Compared to free chemotherapeutic drugs, nano-sized drug delivery systems exhibit enhanced therapeutic effects and reduced in vivo toxicity. Peptide-based have garnered significant attention due the advantageous...
Abstract Local tumor recurrence after surgical resection is a critical concern in cancer therapy, and the current treatments, such as postsurgical chemotherapy, still show undesired side effects. Here nonimplant strategy (transformation induced localization, TIL) presented to situ construct long‐term retentive drug depots, wherein sustained release from fibrous depots results highly efficient suppression of local relapse. The peptide‐based prodrug nanoparticles favorable targeting instantly...