A5100365366- Bladder and Urothelial Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- Orthopaedic implants and arthroplasty
- Wound Healing and Treatments
- Cancer Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Bone fractures and treatments
- Nanoplatforms for cancer theranostics
- Orthopedic Surgery and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Elbow and Forearm Trauma Treatment
- Spine and Intervertebral Disc Pathology
- Hip disorders and treatments
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Immune cells in cancer
- Surgical Sutures and Adhesives
- Urinary and Genital Oncology Studies
- Nerve Injury and Rehabilitation
- Sulfur Compounds in Biology
- Social and Behavioral Studies
- Reconstructive Facial Surgery Techniques
- Facial Trauma and Fracture Management
- Supramolecular Self-Assembly in Materials
- Transgenic Plants and Applications
Harbin Medical University
2018-2024
Shenyang Pharmaceutical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Shandong Provincial Hospital
2022-2024
Shandong First Medical University
2022-2024
University of Southern California
2023
Beijing University of Chinese Medicine
2023
Ningbo University
2023
Zhejiang University
2023
National Center for Nanoscience and Technology
2022
Abstract Intravesical administration of first‐line drugs has shown failure in the treatment bladder cancer owing to poor tumor retention time chemotherapeutics. Herein, we report an intracellular hydrolytic condensation ( IHC ) system construct long‐term retentive nano‐drug depots situ, wherein sustained drug release results highly efficient suppression cancer. Briefly, designed doxorubicin (Dox)‐silane conjugates self‐assemble into silane‐based prodrug nanoparticles, which condense silicon...
Abstract The extended use of androgen deprivation therapy (ADT) may often lead to the progression from castration‐sensitive prostate cancer (CSPC) castration‐resistant (CRPC) in cancer. To address this, it is essential inhibit nuclear translocation receptor (AR) as part an effective disease‐modifying strategy. Microtubules play a central role facilitating AR translocation, highlighting their importance therapeutic target. In this regard, designated targeted microtubules transformable...
Zhang, Hai-Ming M.D.; Yan, Yi-Ping Qi, Ke-Ming Wang, Jia-Qi Liu, Zhi-Fei M.D. Author Information
Background: Skin regeneration from an injury without a scar is still challenge. Methods: A murine model of skin wound was treated with combination extract astragalus and exosomes mesenchymal stem cells (MSCs). CD11b+ CD45 macrophages were detected levels cytokines tested. Results: The expression growth factors VEGF, FGF2 EGF elevated after treatment administered to MSCs. administration ethanolic decreased the TNF-α, IL-1β IL-6 simultaneously increased IL-10. sped up process healing....
Background/Aims: Emerging novel optical imaging techniques with cancer-specific molecular agents offer a powerful and promising platform for cancer detection resection. White-light cystoscopy random bladder biopsies remain the most appropriate but nonetheless suboptimal diagnostic technique cancer, which is associated high morbidity recurrence. However, white-light has intrinsic shortcomings. Although current technologies hold great potential improved accuracy, there are few specific...
Purpose This study aims to demonstrate the use of cartilaginous osseous acetabular angle ratio (AAR) in surgical decision-making for hip dysplasia. Methods Data were collected from patients who underwent an MRI after conservative treatment developmental dysplasia between August 2019 and 2022. The data included demographic information as well anteroposterior pelvic radiograph. index (OAI) was measured using x-ray, while (CAI) acetabulum head (CAHI) MRI. square CAI OAI, AAR, calculated....
Skin wound healing is an important fundamental problem in biological and medical fields. This study aimed to investigate promotion of protein extract from tail-amputated Eisenia foetida (E. foetida) reveal the mechanism correlated with Ras/Raf/MEK/ERK signaling pathway. Proteins extracted E. were applied on rats' full-thickness excisional wounds evaluate their regenerative efficacy. Rat skin tissues around surgical defects analyzed by immunofluorescence staining Western blot methods. The...
Renal Cell Carcinoma In article number 2203518, Ziqi Wang, Lei Hao Wanhai Xu, and co-workers report a transformable extracellular matrix (ECM) deprivation system (EDS) that targets fibronectin for depriving the ECM of renal cell carcinoma (RCC). The cage-like nanofibers formed by EDS deprive RCC cells, which efficaciously reverses anoikis resistance ameliorates RCC's cell-adhesion-mediated drug (CAM-DR).
Bladder cancer (BLCA) remains a difficult malignancy to manage because of its high recurrence, intense follow-up, and invasive diagnostic treatment techniques. Immune checkpoint inhibitors (ICIs) have forged new direction for the BLCA, but it is currently challenging predict whether an individual patient will be sensitive ICIs. We collected 43 urine/tumor samples from BLCA patients primary bladder cells (BCCs) culturing using our previously reported BCC culture platform. used flow cytometry...
Abstract The strategy of in vivo self‐assembly has been developed for improved enrichment and long‐term retention anticancer drug tumor tissues. However, most self‐assemblies with non‐covalent bonding interactions are susceptible to complex physiological environments, leading weak stability loss biological function. Here, we develop a coupling‐induced assembly (CIA) generate covalently crosslinked nanofibers, which is applied situ constructing artificial shell on mitochondria....
Familial hypercholesterolemia (FH) is an inherited disorder with markedly elevated low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease. Although many mutations have been reported in FH, only a few identified as pathogenic mutations. This study aimed to confirm the pathogenicity of LDL receptor (LDLR) c.2160delC variant FH.In this study, proband her family members were systematically investigated, pedigree map was drawn. High-throughput whole-exome...
Objective To explore the clinical significance and inter-observer agreement of a new radiographic classification three lines & one point for developmental dysplasia hip (DDH). Methods From January to June 2016, 69 DDH cases (90 hips) were hospitalized, including 17 boys 52 girls with mean age 21(5-75) months. The involved sides left (n=46) right (n=44). All preoperative pelvic radiographs collected. Three pediatric orthopedists selected classify all according Ji SJ classification,...
Objective To explore the status quo of self-disclosure in patients with stroke and analyze its influencing factors. Methods In this cross-sectional study, totally 248 admitted Neurological Wards a ClassⅢ Grade A hospital Zhengzhou between February August 2019 were selected as subjects by convenient sampling, investigated demographic questionnaire, Distress Disclosure Index (DDI) , Stigma Scale for Chronic Illness (SSCI) Self-rating Depression (SDS) Perceived Social Support (PSSS)...
Radial nerve injury is very common in supracondylar humerus fractures, but radial entrapment between the fracture ends after closed reduction rare, and we report a case of reduction.A 7-year-old boy was admitted to Department Pediatric Orthopedics 24 days with injury. Preoperative ultrasound showed ends, which confirmed by surgery. After release surgery, recovered well.How treat fractures damage remains controversial. We presented rare caused complete motor palsy main trunk above right elbow...
The anatomical features of the atlantoaxial spine increase difficulty complete and safe removal intradural extramedullary (IDEM) tumors. Studies concerning surgical interventions via a posterior approach are limited.To investigate safety efficacy IDEM tumor resection using one-stage approach.We retrospectively analyzed clinical databases for between January 2008 2018. data included position, histopathological type, pre- post-operative Japanese Orthopedic Association (JOA) scores Nurick...
Objective To evaluate the treatment outcomes of anatomic locking titanium plate fixation AO/ASIF type-C fractures distal radius via a volar incision at wrist.Methods A retrospective review was conducted 47 cases treated from June 2007 to 2011 using pre-shaped incision.All were closed and according classification,there 17 type C1 fractures,21 C2 9 C3 fractures.Results Follow-up sufficient for 31 patients with an average 1.5 years (range,1 2.3 years).The complications such as...