A5100460617- Effects and risks of endocrine disrupting chemicals
- Reproductive Biology and Fertility
- Salivary Gland Disorders and Functions
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Forest ecology and management
- Lipid metabolism and disorders
- Forest Management and Policy
- Atmospheric chemistry and aerosols
- Climate variability and models
- Water Quality Monitoring and Analysis
- Ear and Head Tumors
- Land Use and Ecosystem Services
- Reproductive System and Pregnancy
- Wound Healing and Treatments
- Microplastics and Plastic Pollution
- Silk-based biomaterials and applications
- Air Quality and Health Impacts
- Ecology and Vegetation Dynamics Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Plant Molecular Biology Research
- Recycling and Waste Management Techniques
- Ovarian function and disorders
Sichuan Agricultural University
2022-2025
Karolinska Institutet
2020-2024
Karolinska University Hospital
2020-2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
First Affiliated Hospital of Zhengzhou University
2016-2024
Second Affiliated Hospital of Jilin University
2024
Zhongnan University of Economics and Law
2024
Shanghai Children's Medical Center
2023
Shanghai Jiao Tong University
2023
Exposure to persistent organic pollutants (POPs), such as dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCBs), has historically been linked population collapses in wildlife. Despite international regulations, these legacy chemicals are still currently detected women of reproductive age, their levels correlate with reduced ovarian reserve, longer time-to-pregnancy, higher risk infertility. However, the specific modes action underlying associations remain unclear. Here,...
H<sub>2</sub>O<sub>2</sub> was slowly released from CaO<sub>2</sub> particle dissolution and then decomposed into radicals to degrade 2,4-dichlorophenol at a moderate rate.
Leaf angle (LA) is a critical agronomic trait in maize, with more upright leaves allowing higher planting density, leading to efficient light capture and yields. A few genes responsible for variation LA have been identified by map-based cloning. In this study, we cloned maize ZmIBH1-1, which encodes bHLH transcription factor both basic binding region helix-loop-helix domain, the results of qRT-PCR showed that it negative regulator LA. Histological analysis indicated changes were mainly...
Phthalates are found in everyday items like plastics and personal care products. There is an increasing concern that continuous exposure can adversely affect female fertility. However, experimental data lacking to establish causal links between disease humans. To address this gap, we tested the effects of a common phthalate metabolite, mono-(2-ethylhexyl) (MEHP), on adult human ovaries vitro using epidemiologically determined human-relevant concentration range (2.05 nM – 20.51 mM)....
What is the effect of chemical
Organoids are three-dimensional tissue cultures generated using human pluripotent stem cells. It shows great potential in modeling disorders, organogenesis, and developmental disorders. However, they have limitations replicating the complexity of brain lack a complete vasculature to support long-term cultivation endogenous microenvironment simulation. Researchers exploring strategies promote vascularization organoids, including vitro co-culture methods xenotransplantation into highly...
Berberine and carvacrol have demonstrated anti-inflammatory effects; however, their therapeutic potential in endometritis remains unclear. (Aims) This study aimed to examine the properties of berberine a murine model endometritis, with focus on underlying molecular mechanisms. (Main methods) The was established via vaginal instillation 0.1 mL mixture containing Escherichia coli, Staphylococcus aureus, Group B Streptococcus, followed by treatment (4 mg/mL) (0.125 six days post-infection. All...
Endocrine disrupting chemicals (EDCs) are raising concerns about adverse effects on fertility in women. However, there is a lack of information regarding mechanisms and humans. Our study aims to identify endocrine disruption using two EDCs, diethylstilbestrol (DES) ketoconazole (KTZ)1. Human ovarian cortical tissue obtained from Caesarean section patients was exposed 10−9 M - 10−5 KTZ 10−10 10−6 DES vitro for 6 days. Follicle survival growth were studied via histology analysis...
Chemical health risk assessment is based on single chemicals, but humans and wildlife are exposed to extensive mixtures of industrial substances pharmaceuticals. Such exposures life-long correlate with multiple morbidities, including infertility. How combinatorial effects chemicals should be handled in hazard characterization open questions. Further, test systems missing for several relevant outcomes reproductive fertility women. Here, our aim was screen ovarian cell models phthalate induced...
Glucose tolerance progressively declines with age, and there is a high prevalence of type 2 diabetes in the elderly people. Previous studies have reported sex differences risk for diabetes, especially people, whereas reasons these remain poorly understood. This study aims to evaluate effect on glucose-stimulated insulin secretion mitochondrial function pancreatic beta cells Wistar rats.3-month-old 18-month-old rats both sexes were used. Insulin islets was analyzed by islet perifusion assays;...
A crude oil spill in 2014 resulted extensive soil contamination of the hyper arid Evrona Nature Reserve Israel’s Negev Desert. The contaminated soils became highly hydrophobic, threatening existence plants habitat. We hypothesized that bioaugmenting with indigenous biosurfactant-producing, hydrocarbon-degrading bacteria (HDB) would accelerate reduction soil’s hydrophobicity. aimed to isolate and characterize biosurfactant-producing HDBs from desert-contaminated test if they can be used for...
Abstract Background Reproduction in women is at risk due to exposure chemicals that can disrupt the endocrine system during different windows of sensitivity throughout life. Steroid hormone levels are fundamental for normal development and function human reproductive system, including ovary. This study aims elucidate steroidogenesis life-stages ovaries. Methods We have developed a sensitive specific LC-MS/MS method 21 important steroid hormones measured them life stages: media from cultures...
Salivary adenoid cystic carcinoma (SACC) has a unique tendency for perineural invasion (PNI), which results in tumor recurrence and poor prognosis. Recent studies have shown that the chemokine CCL5 its receptor CCR5 play important roles metastasis. However, role of CCL5/CCR5 axis PNI SACC not been studied to date. In present study, we evaluated expression cases nerve tissues, performed series vitro assays with cell line, SACC-83, indicate SACC. We found (35.9%; 23/64) (70.3%; 45/64) were...
The Kathmandu Valley in Nepal experiences poor air quality, especially the dry winter season. In this study, we investigated concentration, chemical composition, and sources of fine coarse particulate matter (PM