A5072961920- Cancer Cells and Metastasis
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Hair Growth and Disorders
- Digestive system and related health
- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related gene regulation
- Skin and Cellular Biology Research
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Mesenchymal stem cell research
- Hippo pathway signaling and YAP/TAZ
- Muscle Physiology and Disorders
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Renal and related cancers
- Circular RNAs in diseases
First Affiliated Hospital of Zhengzhou University
2023-2025
China Agricultural University
2015-2024
University of California, Irvine
2006-2024
Fudan University
2024
Soochow University
2008-2024
First Affiliated Hospital of Soochow University
2011-2024
Zhengzhou University
2023-2024
Agrobiotechnology Institute
2020
Beijing Advanced Sciences and Innovation Center
2019
University of Minnesota
2015
Object. By pursuing a policy of very early aneurysm treatment in neurosurgical centers, in-hospital rebleeds can be virtually eliminated. Nonetheless, as many 15% patients with rupture suffer ultraearly rebleeding high mortality rates, and these individuals are beyond the reach even most ambitious protocol for diagnosis referral. Only drugs given immediately after subarachnoid hemorrhage (SAH) has been established at local hospital level can, theory, contribute to minimization such...
Objective Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced studies in animals. The aim the study is to characterise relationships between intestinal microbiome composition, toxins and human end-stage disease (ESRD). Design Characterisation microbiome, serum faecal metabolome phenotypes a cohort 223 patients ESRD 69 healthy controls. Multidimensional data integration reveal links these datasets use chronic kidney (CKD)...
Intestinal diseases caused by sleep deprivation (SD) are severe public health threats worldwide. This study focuses on the effect of melatonin intestinal mucosal injury and microbiota dysbiosis in sleep-deprived mice. Mice subjected to SD had significantly elevated norepinephrine levels decreased content plasma. Consistent with decrease levels, we observed a antioxidant ability, down-regulation anti-inflammatory cytokines up-regulation pro-inflammatory mice, which resulted colonic injury,...
Mucus is a viscoelastic biological hydrogel that protects the epithelial surface from penetration by most nanoparticles, which limits efficiency of oral drug delivery. Pursuing highly efficient, biocompatible, and biodegradable vehicles central importance to development promising nanomedicine. Here, we prepared five peptosomes (PSs) with various sizes, shapes, rigidities based on self-assembly amphiphilic α-lactalbumin (α-lac) peptides partial enzymolysis cross-linking. The mucus permeation...
MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal and tumorigenesis. However, the vivo functions of specific microRNAs controlling mammary (MaSC) activity breast cancer formation remain poorly understood. Here we show that miR-31 is highly expressed MaSC-enriched basal population tumors, regulated by NF-κB signaling. We demonstrate promotes epithelial proliferation MaSC expansion at expense differentiation vivo. Loss compromises tumor growth, reduces...
The MSI2 RNA-binding protein is a potent oncogene playing key roles in haematopoietic stem cell homeostasis and malignant haematopoiesis. Here we demonstrate that expressed the intestinal compartment, its expression elevated colorectal adenocarcinomas, loss-of-function abrogates cancer growth. gain-of-function epithelium drug-inducible mouse model sufficient to phenocopy many of morphological molecular consequences acute loss APC tumour suppressor Wnt-independent manner. Transcriptome-wide...
Abstract Satellite cells are crucial for skeletal muscle regeneration, but the molecular mechanisms regulating satellite not entirely understood. Here, we show that immunoglobulin superfamily containing leucine-rich repeat (Islr), a newly identified marker mesenchymal stem cells, stabilizes canonical Wnt signaling and promote regeneration. Loss of Islr delays regeneration in adult mice. In absence Islr, myoblasts fail to develop into mature myotubes due defective differentiation. interacts...
Members of the Msi family RNA-binding proteins have recently emerged as potent oncoproteins in a range malignancies. MSI2 is highly expressed hematopoietic cancers, where it required for disease maintenance. In contrast to system, colorectal cancers can express both members, MSI1 and MSI2. Here, we demonstrate that, intestinal epithelium, Msi1 Msi2 analogous oncogenic effects. Further, comparison Msi1/2-induced gene expression programs transcriptome-wide analyses Msi1/2-RNA-binding targets...
Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi human often display excessive hair growth, suggesting cell hyperactivity. Here, using genetic mouse models of nevi2,3, we show that dermal clusters senescent melanocytes drive epithelial exit and change their transcriptome composition, potently enhancing renewal. Nevus distinct...
Ferroptosis plays important roles both in normal physiology and multiple human diseases. It is well known that selenoprotein named glutathione peroxidase 4 (GPX4) a crucial regulator for ferroptosis. However, it remains unknown whether other selenoproteins responsible the regulation of ferroptosis, particularly gut In this study, observed Selenoprotein I (Selenoi) prevents ferroptosis by maintaining ether lipids homeostasis. Specific deletion Selenoi intestinal epithelial cells induced...
Aberrant release of mitochondrial reactive oxygen species (mtROS) in response to cellular stress is well known for promoting cancer progression. However, precise molecular mechanism by which mtROS contribute epithelial progression remains only partially understood. Here, using colorectal (CRC) models, we show that upon sensing excessive mtROS, phosphatase PGAM5, normally localizes the mitochondria, undergoes aberrant cleavage presenilin-associated rhomboid-like protein (PARL), becoming...
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated consistent with a role cell state regulation. We found that Msi genes rarely mutated frequently overexpressed human cancers associated an epithelial-luminal state. Using ribosome profiling RNA-seq analysis, we regulate translation implicated epithelial biology epithelial-to-mesenchymal transition (EMT), promote splicing pattern. Overexpression...
Regeneration of the intestinal epithelium is driven by multiple stem cell (ISC) types, including an active, radiosensitive Wnt
Intestinal regeneration and tumorigenesis are believed to be driven by intestinal stem cells (ISCs). Elucidating mechanisms underlying ISC activation during can help uncover the principles of homeostasis disease including colorectal cancer. Here we show that miR-31 drives proliferation, protects ISCs against apoptosis, both in response ionizing radiation injury. Furthermore, has oncogenic properties, promoting tumorigenesis. Mechanistically, acts balance input from Wnt, BMP, TGFβ signals...
Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation cis-regulatory elements (CREs) much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case de has been reported to date, in fish without involvement phenotype alteration. Yet, this event likely occurs other animals helps drive genetic/phenotypic variation. Using a porcine model spontaneous hearing loss...
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth HFs is sufficient to drive periodicity excitability regeneration. Model simulations experimental data reveal mouse skin behaves as a heterogeneous regenerative field, composed anatomical domains where have distinct cycling dynamics. Interactions between fast-cycling chin ventral slow-cycling dorsal...
Background: Accumulating evidences indicate that nanomedicines greatly decrease the side effects and enhance efficacy of colorectal cancer (CRC) treatment. In particular, use rectal delivery nanomedicines, with advantages such as fast therapeutic a diminishing hepatic first-pass effect, is currently emerging. Method: We established CRC targeted system, in which α-lactalbumin peptosomes (PSs) co-loaded microRNA (miR)-31 inhibitor (miR-31i) curcumin (Cur) were encapsuslated thiolated TEMPO...
A certain number of epithelial cells in intestinal crypts are DNA damage resistant and contribute to regeneration. However, the cellular mechanism underlying regeneration remains unclear. Using lineage tracing, we show that marked by an Msi1 reporter (Msi1+) right above Lgr5high exhibit resistance. Single-cell RNA sequencing reveals Msi1+ heterogeneous with majority being stem (ISCs). The damage-resistant subpopulation is characterized low-to-negative Lgr5 expression more rapidly cycling...
Oxidative stress, which can be activated by a variety of environmental risk factors, has been implicated as an important pathogenic factor for inflammatory bowel disease (IBD). However, how oxidative stress drives IBD onset remains elusive. Here, we found that was strongly in inflamed tissues from both ulcerative colitis patients and Crohn’s patients, it caused nuclear-to-cytosolic TDP-43 transport reduction the protein level. To investigate function IBD, inducibly deleted exons 2 to 3...