A5024859470- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Natural product bioactivities and synthesis
- Click Chemistry and Applications
- Plant biochemistry and biosynthesis
- Supramolecular Self-Assembly in Materials
- Biological Activity of Diterpenoids and Biflavonoids
- Glycosylation and Glycoproteins Research
- Sulfur Compounds in Biology
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- Histone Deacetylase Inhibitors Research
- Phytochemistry and Biological Activities
- Ubiquitin and proteasome pathways
- Liver Disease Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Metabolism, Diabetes, and Cancer
- Photochromic and Fluorescence Chemistry
- Nanoparticle-Based Drug Delivery
- Epigenetics and DNA Methylation
- Carbohydrate Chemistry and Synthesis
Shanghai Institute of Materia Medica
2016-2025
Shanghai Institute of Nutrition and Health
2019-2025
University of Chinese Academy of Sciences
2017-2024
National Center for Drug Screening
2015-2024
Chinese Academy of Sciences
2015-2024
Nanjing University of Chinese Medicine
2022-2024
Center for Excellence in Molecular Cell Science
2020-2023
Shanghai Jiao Tong University
2023
Qingdao National Laboratory for Marine Science and Technology
2022
State Key Laboratory of Drug Research
2014-2021
Here, we report a β-galactosidase (β-Gal)-responsive photochromic fluorescent probe, NpG, that was designed to prebind human serum albumin (HSA) form the probe/protein hybrid, NpG@HSA. The formation of NpG@HSA led an increase in fluorescence emission (520 nm) corresponding binding naphthalimide unit with HSA. In addition, this enabled visualization spiropyran aqueous media. Our hybrid approach afforded unique imaging platform enhanced cell permeability and solubility capable visualizing...
Changes in adenosine triphosphate (ATP) and peroxynitrite (ONOO–) concentrations have been correlated a number of diseases including ischemia-reperfusion injury drug-induced liver injury. Herein, we report the development fluorescent probe ATP-LW, which enables simultaneous detection ONOO– ATP. selectively oxidizes boronate pinacol ester ATP-LW to afford 4-hydroxy-1,8-naphthalimide product NA-OH (λex = 450 nm, λem 562 nm or λex 488 568 nm). In contrast, binding ATP induces spirolactam ring...
Abstract Development of powerful fluorescence imaging probes and techniques sets the basis for spatiotemporal tracking cells at different physiological pathological stages. While current approaches rely on passive probe–analyte interactions, here we develop photochromic fluorescent glycoprobes capable remote light-controlled intracellular target recognition. Conjugation between a fluorophore spiropyran produces probe, which is subsequently equipped with glycoligand “antenna” to actively...
A galatosyl azidonaphthalimide probe is developed for the selective, fluorogenic imaging of hepatocellular H<sub>2</sub>S.
Economical nanocomposites based on π-stacking of N-acetyl glycosyl rhodamine B to graphene oxide (GO) are simply prepared. These "sweet" GO-materials proven be admirable for the fluorogenic recognition specific intercellular sugar-based ligand-glycoprotein receptor interactions interest.
A 2D "glycosheet" based on supramolecular self-assembly between MoS2 and fluorescent glycoligands is developed. The composite material proven suitable for targeted intracellular production of reactive oxygen species (singlet oxygen) by the sequential control a receptor endocytosis light irradiation.
Abstract Reactive oxygen species (ROS) consist of a diverse range oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in damage tissues cells. Therefore, ROS have been implicated an array diseases including cancer, inflammation, neurodegenerative such as Parkinson's disease Alzheimer's disease. Owing simplicity, sensitivity, selectivity fluorescence‐based strategies,...
Abstract Chronic inflammation and an immunosuppressive microenvironment promote prostate cancer (PCa) progression diminish the response to immune checkpoint blockade (ICB) therapies. However, it remains unclear how what extent these two events are coordinated. Here, we show that ARID1A, a subunit of SWI/SNF chromatin remodeling complex, functions downstream inflammation-induced IKKβ activation shape tumor (TME). Prostate-specific deletion Arid1a cooperates with Pten loss accelerate...
Abstract Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer metastasis, accompanied with vast epigenetic changes. AMP-activated protein kinase (AMPK), cellular energy sensor, regulatory roles multiple biological processes. Although few studies have shed light on AMPK regulating the inside mechanisms remain unknown. Herein we show that activation by metformin relieves repressive H3K9me2-mediated silencing of epithelial genes (e.g., CDH1) during EMT processes and...
This study depicts the 'click' construction of a water-soluble galactosyl rhodamine that can selectively probe mercury ions internalized by hepatoma cells over other cancer cells.