A5100776813- Reproductive Biology and Fertility
- Ovarian function and disorders
- Dialysis and Renal Disease Management
- RNA modifications and cancer
- Cancer Research and Treatments
- Bone Metabolism and Diseases
- Telomeres, Telomerase, and Senescence
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Sperm and Testicular Function
- Mesenchymal stem cell research
- Mine drainage and remediation techniques
- Aquatic Ecosystems and Phytoplankton Dynamics
- Multiple Sclerosis Research Studies
- Connective tissue disorders research
- Chronic Kidney Disease and Diabetes
- Arsenic contamination and mitigation
- Neurogenesis and neuroplasticity mechanisms
- Protein Degradation and Inhibitors
- Ferroptosis and cancer prognosis
- Gout, Hyperuricemia, Uric Acid
- Soil and Water Nutrient Dynamics
- Photoacoustic and Ultrasonic Imaging
- Heart Failure Treatment and Management
- Peptidase Inhibition and Analysis
Shanghai East Hospital
2024-2025
China Pharmaceutical University
2022-2024
State Key Laboratory of Natural Medicine
2022-2024
Qilu University of Technology
2024
Shandong Academy of Sciences
2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Ministry of Ecology and Environment
2017-2024
Jilin University
2008-2024
Shanghai Jiao Tong University
2020-2023
Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron-dependent lipid peroxidation. Though multiple genes (including SLC7A11 GPX4) have been demonstrated to play key roles in ferroptosis, little known about the epigenetic regulation this process. Here, we report that KDM3B, histone H3 lysine 9 demethylase, can protect against ferroptosis induced Erastin, an inhibitor SLC7A11. KDM3B overexpression HT-1080 cells results decreased methylation. Furthermore,...
Although significant progress in identifying molecular mediators of fibrosis is made, there still controversy regarding the role and mechanism autophagy kidney fibrosis. Here, this study finds that related 5 (ATG5) obviously increased uric acid (UA), aristolochic (AA) transforming growth factor-β1 (TGF-β1)-induced HK-2 cells, as well kidneys from patients with chronic disease (CKD) mice hyperuricemic nephropathy (HN), (AAN) unilateral renal ischemia-reperfusion injury (uIRI). Conditional...
Mammalian focal adhesion proteins Pinch1 and Pinch2 regulate integrin activation cell–extracellular matrix migration. Here, we show that deleting in osteocytes mature osteoblasts using the 10-kb mouse Dmp1-Cre globally (double KO; dKO) results severe osteopenia throughout life, while ablating either gene does not cause bone loss, suggesting a functional redundancy of both factors bone. Pinch deletion generates signals inhibit osteoblast formation. Pinch-deficient conditioned media from dKO...
Abstract Osteocytes act as mechanosensors in bone; however, the underlying mechanism remains poorly understood. Here we report that deleting Kindlin-2 osteocytes causes severe osteopenia and mechanical property defects weight-bearing long bones, but not non-weight-bearing calvariae. loss impairs skeletal responses to stimulation bones. Control cKO mice display similar bone induced by unloading. However, unlike control mice, fail restore lost after reloading. Osteocyte deletion focal adhesion...
The Notch signalling pathway in the mammalian ovary regulates granulosa cell proliferation. However, effects of on steroidogenesis are unclear. In this study we cultured mouse ovarian cells from preantral follicles invitro and observed effect through overexpression, knockdown inhibition signalling. Activation decreased progesterone oestrogen secretion. contrast, increased production oestrogen. Expression genes for steroidogenic-related enzymes, including 3β-hydroxysteroid dehydrogenase, p450...
Abstract The disruptor of telomeric silencing 1-like (DOT1L), a specific histone methyltransferase that catalyzed methylation H3 on lysine 79, was associated with the pathogenesis many diseases, but its role in peritoneal fibrosis remained unexplored. Here, we examined DOT1L expression and activation protein tyrosine kinases development fibrosis. We found significant rise fibrotic peritoneum tissues from long-term PD patients mice. Inhibition significantly attenuated profibrotic phenotypic...
Abstract Tyrosine kinase inhibitors have been the standard treatment for patients with Philadelphia chromosome-positive (Ph + ) leukemia. However, a series of issues, including drug resistance, relapse and intolerance, are still an unmet medical need. Here, we report targeted siRNA-based lipid nanoparticles in Ph leukemic cell lines gene therapy leukemia, which specifically targets recently identified NEDD8 E3 ligase RAPSYN cells to disrupt neddylation oncogenic BCR-ABL. To achieve...
Quantitative studies on sediment release fluxes and their impact water quality are important for pollution control, ecological restoration, safety, human health. In this study, we conducted high-frequency, synchronous field observations of meteorology, hydrology, to determine the relationship between rate wind speed in central region Lake Taihu. We combined these results with our previous findings from other regions establish temporal–spatial variation patterns lake. then calculated annual...
Background Neuromyelitis Optica spectrum disorder (NMOSD) is severe relapsing and disabling autoimmune disease of the central nervous system. Its optimal first-line treatment to reduce relapse rate ameliorate neurological disability remains unclear. We will conduct a prospective, multicenter, randomized, placebo-controlled clinical trial study safety effectiveness human umbilical cord mesenchymal stem cells (hUC–MSCs) in treating NMOSD. Methods The planned recruit 430 AQP4-IgG seropositive...
Dendritic cells (DCs) that can prime antitumor responses show great potential in tumor immunotherapy, whereas the unsatisfactory effect which be ascribed part to high expression of inhibitory cytokines, such as suppressor cytokine signaling 1 (SOCS1), restricts their application. Thus, silencing these genes DCs is essential for DC-based therapy. However, safe and effective delivery siRNA still faces challenges. Herein, we designed single-component lipid nanoparticles comprising a solely...
Abstract Methods: Relevant potential targets for EC were obtained based on Traditional Chinese Medicine System Pharmacology Database (TCMSP), a bioinformatics analysis tool molecular mechanism of (BATMAN-TCM) and STITCH databases. The Online Mendelian Inheritance in Man (OMIM) GeneCards databases utilized to screen the known POI-related targets, while Cytoscape software was used network construction visualization. Then, Gene Ontology (GO) pathway enrichment carried out by Annotation,...
Abstract The L -isoleucine-4-dioxygenase can convert isoleucine into (2 S ,3 R ,4 )-4-hydroxyisoleucine (4-HIL), a naturally occurring hydroxy amino acid which is promising compound for drug and functional food development because of its management diabetes mellitus reducing total cholesterol levels in the body. Here, novel ( Ra IDO) from Rahnella aquatilis was cloned, expressed characterized, as one only few reported L-isoleucine-4-dioxygenase. Compared to functionally structurally...
Whether angiotensin receptor-neprilysin inhibitor (ARNI) can reduce the incidence of cardiovascular events and improve peritoneal function in dialysis (PD) patients remains unclear. Thus, this study aims to clarify role ARNI PD patients. This was a multicenter retrospective study. A total 102 were enrolled for analysis. Patients who continuously used 12 months assigned group (n = 55), while those never control 47). Clinical indicators risk factors analyzed, along with vitro experiments on...
Hepatic insulin clearance is essential for maintaining glucose homeostasis and closely linked to metabolic disorders such as obesity, resistance, diabetes. Accurate measurement of vital understanding the underlying mechanisms these conditions. This protocol presents a straightforward user-friendly hepatic perfusion procedure in mice, specifically designed directly evaluate rate. The method involves precise cannulation portal vein suprahepatic inferior vena cava create an situ system that...