A5103436215- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Protease and Inhibitor Mechanisms
- Silicon and Solar Cell Technologies
- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- Semiconductor materials and interfaces
- Alzheimer's disease research and treatments
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Dermatologic Treatments and Research
- Invertebrate Immune Response Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Mitochondrial Function and Pathology
- Tannin, Tannase and Anticancer Activities
- Hemoglobin structure and function
- interferon and immune responses
- Thin-Film Transistor Technologies
- Drug-Induced Adverse Reactions
- Heme Oxygenase-1 and Carbon Monoxide
- Phytoestrogen effects and research
- Peptidase Inhibition and Analysis
- Pregnancy and Medication Impact
- Trace Elements in Health
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2021-2024
Palo Alto University
2022
Stanford University
2016-2022
First Affiliated Hospital of Chengdu Medical College
2021
Wenzhou Central Hospital
2021
China Medical University
2010-2018
First Hospital of China Medical University
2018
Peking University
2018
Qilu Hospital of Shandong University
2014
East China University of Science and Technology
2012
Background: Resistance to radiation therapy is still a challenge for treatment of pancreatic cancer (PC). Long non-coding RNAs (lncRNA) HOTAIR has been found play oncogenic role in several cancers. However, the correlation between and radiotherapy PC unclear. Methods: TCGA data was collected analyze expression its relationship with progression. A series functional experiments were conducted explore radiosensitivity underlying molecular mechanisms. Results: By analysis data, we tissues...
Although the expression pattern and biological functions of ataxia–telangiectasia group D complementing gene (ATDC) had been implicated in several types cancer, roles potential mechanisms ATDC lung cancer cell invasion are still ambiguous. In this study, we used gain- loss-of-function analyses to explore invasion. siRNA knockdown impaired A549 H1299 lines, its overexpression promoted HBE line. may contribute invasive ability cells by promoting invasion-related matrix metalloproteinase 9...
This work presents titanium oxide (TiOx) and nickel (NiOx) as promising carrier-selective interlayer materials for metal-interlayer–semiconductor contacts silicon solar cells. The electron-conducting, hole-blocking behavior of TiOx the opposite NiOx are investigated using transmission-line-method. Fermi level depinning effect tunneling resistance demonstrated to be dependent on thickness annealing temperature. is furthermore experimentally capable improving effective minority carrier...
The purpose of this study is to develop betulinic acid loaded nanoliposomes improve the chemotherapy effect colorectal cancer. cellular uptake and anti-tumor effects in vitro were characterized evaluated, their on glycolysis, glutamine decomposition key anti-cancer targets analyzed. Moreover, anticancer efficacy was assessed vivo . Compared with free , activity acid-loaded significantly enhanced; these suppressed proliferation glucose cancer cells. Mechanistically, anti-colorectal confirmed...
Abstract Background There is limited research assessing the utility of Xpert Mycobacterium tuberculosis /rifampin (MTB/RIF) assay for analysis bronchoalveolar lavage fluid (BALF) in Chinese patients with suspected pulmonary (PTB). Thus, our objective was to determine diagnostic accuracy MTB/RIF and evaluate its determination rifampicin resistance. Methods We retrospectively analyzed BALF from 214 PTB between January 2018 March 2019. Using mycobacterial culture or final clinical diagnosis as...
<i>Background/Aims:</i> Glutamine showed potential cytoprotective activity probably due to induction of heme oxygenase-1 (HO-1). We thus investigated the effect glutamine in vitro on anoxia/reoxygenation (A/R) injury renal tubular epithelial cells. <i>Methods:</i> Human proximal cells (HK-2) were subjected A/R with or without glutamine, after which viability and apoptosis determined by MTT assay annexin V flow cytometry, respectively. Meanwhile, expression HO-1,...
Thin film crystalline silicon (c-Si) solar cells have been a hot topic of photovoltaic research recently because its lower material consumption could potentially lead to capital expenditure. However, contact recombination is more prominent in thin-film c-Si compared with it traditional due higher carrier concentration. To address such challenge, this work presents design metal-insulator-semiconductor (MIS) contact, based on thin TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Methods: Relevant potential targets for EC were obtained based on Traditional Chinese Medicine System Pharmacology Database (TCMSP), a bioinformatics analysis tool molecular mechanism of (BATMAN-TCM) and STITCH databases. The Online Mendelian Inheritance in Man (OMIM) GeneCards databases utilized to screen the known POI-related targets, while Cytoscape software was used network construction visualization. Then, Gene Ontology (GO) pathway enrichment carried out by Annotation,...
Interleukin-1 and Cancer Xiang WU, Ke XU Core Facility Center, Tianjin Medical University General Hospital; Key Laboratory of Lung Metastasis Tumor Microenviroment, Institute, Hospital, 300052, China Corresponding author: XU, E-mail: ke_xu@hotmail.com This study was supported by grants from National Natural Science Foundation (to XU)(No.30873035), Project Municipal Education Commission XU)(No.ZD200714), Technology XU)(No.10JCZDJC20800), the Start Up Fund Ministry XU).
A 34-year-old female patient took by herself ibuprofen sustained-release capsules 300 mg orally due to systemic muscle trauma. One day later, diffused erythema papules occurred on her neck, gradually involving eyes, mouth, nose, trunk and limbs, accompanied fever. The drug was stopped at the same day, but symptoms were aggravated progressively. She diagnosed with Stevens-Johnson syndrome. Glucocorticoids, human gamma globulin symptomatic supportive treatments given. Fourteen days improved 30...
Abstract Tauopathies are neurodegenerative diseases caused by pathologic misfolded tau protein aggregation in the nervous system. Population studies implicate EIF2AK3 ( eukaryotic translation initiation factor 2 alpha kinase 3 ), better known as PERK R-like endoplasmic reticulum a genetic risk several tauopathies. is key regulator of intracellular proteostatic mechanisms – Unfolded Protein Response (UPR) and Integrated Stress (ISR). Previous found that tauopathy-associated variants encoded...
Abstract Objective: SOX2 is related to drug resistance in many types of cancer, including lung but the underlying mechanism still not fully understood. Herein, we investigated role and its regulatory signaling cisplatin-treated non-small-cell cancer (NSCLC). Methods: Cisplatin-resistant NSCLC A549/CDDP cells, parental A549 cells NCI-H460 were selected for experiments. The effects on cell viability, proliferation, apoptosis evaluated vitro. Western blotting, real-time quantitative PCR (qPCR),...
Background and Aim: Non-small cell lung cancer (NSCLC) is one of the most common clinical malignant tumors.According to World Health Organization (WHO), NSCLC has become tumor with highest morbidity mortality.This paper aims investigate mechanism LncRNAG058036 in NSCLC.Methods: was screened out by bioinformatics analysis, expression G058036 tissues adjacent non-cancer compared quantitative real-time polymerase chain reaction.Survival analysis Patients NSCLC.G058036shRNA used transfection...