Abstract Insufficient drug loading and leakage of payload remain major challenges in designing liposome-based delivery systems. These phenomena can limit duration effect cause toxicity. Targeting the rate-limiting step release from liposomes, we modify (aromatized) them to have aromatic groups within their lipid bilayers. Aromatized liposomes are designed with synthetic phospholipids covalently conjugated onto acyl chains. The optimized aromatized liposome increases significantly decreases...

Abstract The prevalence of ear disorders has spurred efforts to develop drug delivery systems treat these conditions. Here, recent advances in that access the through tympanic membrane (TM) are reviewed. Such methods either non‐invasive (placed on surface TM), or invasive middle ear, ideally round window [RW]). major hurdles otic identified and highlighted representative examples used for across TM (crossing RW also) inner ear.

Abstract Delivery of hydrophilic small molecule therapeutics by traditional drug delivery systems is challenging. Herein, we have used the specific interaction between DNA aptamers and drugs to create simple effective depot systems. The binding a phosphorothioate-modified aptamer formed non-covalent aptamer/drug complexes, which created sustained release system. We demonstrated effectiveness this system with molecules, site 1 sodium channel blockers tetrodotoxin saxitoxin. aptamer-based...

<b><i>Background:</i></b> Parkinson’s disease (PD) is a common neurodegenerative disease. With the aging of Chinese population, it important to understand prevalence PD in elderly. <b><i>Objective:</i></b> Little data are available on current China. The aim this study was determine individuals aged 65 years and older analyze associated risk factors. <b><i>Methods:</i></b> We performed population-based cross-sectional...

The practical utilization of solar-driven water splitting is restricted by the difficulty this type in producing hydrogen and oxygen products with same photocatalyst.

// Liwei Liu 1, * , Chao Zhang Xiyu Li 1 Wenjia Sun Shenghui Qin Lingzhi and Xi Wang Institute of Pathology, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan 430030, China These authors have contributed equally to this work Correspondence to: Wang, email: xwang@mails.tjmu.edu.cn Keywords: colon cancer, miR-223, p120, RhoA, β-catenin Received: December 21, 2016 Accepted: June 19, 2017 Published: July 25, ABSTRACT microRNA (miRNA) dysregulation is frequently...

Mild cognitive impairment (MCI) in multiple-system atrophy (MSA) patients is common but remains poorly characterized, and the related factors are unclear. This retrospective study included 200 consecutive with a clinical diagnosis of possible or probable MSA, 102 MSA MCI (MSA-MCI), 98 normal cognition (MSA-NC). Cognitive profiles were compared between MSA-MCI MSA-NC using MoCA. In addition, demographic as well major motor nonmotor symptom differences patients. The median MMSE score was 26...

Misuse of opioids can lead to a potential lethal overdose. Timely administration naloxone is critical for survival. Here, we designed polymer–naloxone conjugate that provide on-demand phototriggered opioid reversal. Naloxone was attached the polymer poly(lactic-co-glycolic acid) via photocleavable coumarin linkage and formulated as injectable nanoparticles. In absence irradiation, formulation did not release naloxone. Upon irradiation with blue (400 nm) light, nanoparticles released free...

Solar-driven water splitting is an appealing strategy to produce hydrogen energy. However, the non-negligible chance of reverse reactions due a mixture molecules (H2) with oxygen species poses challenges for safe H2 collection and delivery, which hinders its applications. Using first-principles simulations, we propose hybrid structure design where metal clusters TM4 (TM = Au/Pt) are encapsulated in boron–carbon–nitride nanotube (BCNNT) decorated CuN3 group. It can readily absorb...

Background and Introduction: Acute otitis media is the most common reason for a visit to pediatrician, often requiring systemic administration of oral antibiotics. Local drug therapy applied middle ear could avoid side effects associated with antibiotic administration, however in majority patients this would require drugs diffuse across an intact tympanic membrane. Experimental methods testing trans-tympanic flux human tissues situ be highly valuable guide development local delivery ear....

Localized and non-invasive delivery of therapeutics across barriers in the body is challenging. Examples include flux drugs tympanic membrane (TM) for treatment middle ear infections, round window to treat inner disease. With emergence macromolecular therapies, question arises as whether such can be achieved with macromolecules. Here, we have used polyethylene glycols (PEGs) solutions investigate permeation TM chinchilla ex vivo. As molecular weight PEG increased, decreased, an exponential...

Drug delivery directly across the tympanic membrane (TM) could eliminate systemic exposure to antibiotics prescribed for otitis media, most common reason pediatricians prescribe antibiotics. Here, we hypothesized that inducing inflammation of TM enhance drug flux TM. We demonstrated ciprofloxacin was greatly increased by treatment with proinflammatory agent histamine. That enhancement blocked concurrent blockers histamine receptor 1. Treatment able sufficiently eradicate media in vivo...

Thermoresponsive polymers that undergo sol-gel transitions in the physiological temperature range have been widely used biomedical applications. However, some commercially and clinically available thermoresponsive materials, particularly poloxamer 407 (P407), significant drawback of insufficient gel strength, which limit their performance. Furthermore, co-delivery with small molecules, including chemical permeation enhancers (CPEs) can further impair physical properties P407. Here, we...

We previously identified a highly active homodimeric FMN-dependent NADH-preferred azoreductase (AzoA) from

Abstract Objective To analyze differentially expressed genes (DEGs) related to mitophagy between Alzheimer's disease (AD) patients and normal controls using bioinformatics machine learning methods screen for key provide theoretical support the study of AD pathogenesis therapeutic targets. Methods Data microarrays were obtained from GEO database, DEGs by differential expression analysis gene data R. The intersected with mitophagy-related obtain interest, then group was enriched Gene Ontology...

By conducting a meta-analysis, this study seeks to examine the efficacy of statins on type 2 diabetes mellitus patients with cardiovascular disease. The key words atuofatating, ruishufatating, tangniaobing and xinxueguanjibing were used search Zhongguozhiwang Wanfang databases, comprehensive was conducted in Cochrane library Embase, Web Science, PubMed using keywords atorvastatin, rosuvastatin, diabetes, Two evaluators scores evaluate quality articles. Collect relevant data from included...

This study investigated the effects of Cong Rong Shu Jing (CRSJ) compound on endoplasmic reticulum stress in a rat model Parkinson′s disease (PD). A total 40 rats were subcutaneously injected with rotenone‐sunflower oil emulsion into back neck to establish PD. These PD randomly divided low‐, medium‐, and high‐dose groups (intragastric administration 0.5, 1, 2 g/kg CRSJ, respectively) group solvent; 10 per group). Furthermore, each attributed control vehicle (both received intragastric CRSJ...

This study aimed to better understand whether and how the reactive 1,2-dicarbonyl precursors of advanced glycation end products (AGEs), glyoxal (GO) methylglyoxal (MGO), cross intestinal barrier by studying their transport in vitro Caco-2 transwell system. The results reveal that GO, MGO Nε-(carboxymethyl)lysine (CML), latter studied for comparison, are transported across cell layer via both active passive paracellular accumulate cells, albeit all a limited extent. Besides, dicarbonyl...

Advanced robot's navigation system based on GPS/INS is established in order to meet its working surroundings and task's demand. Centralized open-loop Kalman filter applied the system. devices' output difference filter's input. The position-velocity integrated measurement equation deduced locomotion performance Simulation experiments are conducted under MATLAB software environment. experiment results show that system's noise retained precision improved effectively.

Objective To investigate the prevalence of autonomic dysfunction and its influencing factors in elderly Jizhou community Tianjin. Methods By using a cross-sectional study, questionnaire survey was conducted order to factors. Results A total 1 292 patients were enrolled.Of them, 196 cases had dysfunction(15.2%, 196/1 292). The main symptoms frequent urination, urination urgency, incontinence(19.7%, 255/1 292)and constipation(15.9%, 205/1 Multivariate Logistic regression analysis...