A5029246969- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Cytokine Signaling Pathways and Interactions
- Acute Myeloid Leukemia Research
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Bone Tissue Engineering Materials
- Developmental Biology and Gene Regulation
- Ovarian cancer diagnosis and treatment
- Protein Degradation and Inhibitors
- Protein Kinase Regulation and GTPase Signaling
- Cancer Research and Treatment
- Axon Guidance and Neuronal Signaling
- HER2/EGFR in Cancer Research
- Viral-associated cancers and disorders
- Biomarkers in Disease Mechanisms
Third Affiliated Hospital of Zhengzhou University
2021-2023
Southern Medical University
2022
Nanfang Hospital
2022
Gansu Provincial Maternal and Child Health Hospital
2021
Jiangsu Normal University
2019-2020
East China University of Science and Technology
2012-2016
Wayne State University
1997
Society of Environmental Toxicology and Chemistry
1997
Colorectal carcinoma is a frequent cause of cancer-related death in men and women. miRNAs (microRNAs) are endogenous small non-coding RNAs that regulate gene expression negatively at the post-transcriptional level. In present study we investigated possible role microRNAs development MDR (multidrug resistance) colorectal cells. We analysed miRNA levels between cell line HCT116/L-OHP cells their parent HCT116 using microarray. miR-297 showed lower compared with its parental MRP-2...
MicroRNAs play key roles in many biological processes, and are frequently dysregulated tumor cells. However, there few studies on how microRNAs dysregulated. miR-139-5p, an important suppressor, is often underexpressed gastrointestinal cancer Here, we describe post-transcriptional regulation of this intronic microRNA human colorectal cancer. miR-139-5p expressed independently its overexpressed host gene PDE2A tissues cell lines. The target genes IGF1R, ROCK2 RAP1B exert regulatory effects...
MiR-92b was upregulated in gliomas. However, the association of miR-92b with glioma cell apoptosis and survival remains unknown.Proliferation capability cells upon tranfection mimics or inhibitors detected by mutiple analyses, including MTT assays, colony formation assay. Apoptosis abilities were flow cytometric analysis. The target determined luciferase reporter western blot. outcome examined twenty patients.MiR-92b expression significantly increased high-grade gliomas compared low-grade...
MiRNAs may promote or inhibit tumor recurrence and drug resistance. MiR-139-5p is reportedly downregulated in colorectal cancer patient samples, but it unknown whether how miR-139-5p regulates Cancer stem cells (CSCs) are postulated to be important promoters of multiple resistance (MDR). In this study, we established a MDR cell model which strongly expressed the CSC-associated biomarkers CD44 CD133. expression was reduced lines, while overexpression reversed CD44+/CD133+-associated MDR. We...
This study investigated the effect of water stress, simulated by polyethylene glycol (PEG-6000) method, on nitrogen (N) metabolism in leaves and roots hydroponically grown sweet potato seedlings, Xushu 32 (X32) Ningzishu 1 (N1). The concentrations PEG-6000 treatments were 0%, 5% 10% (m/v). results showed that drought-treated plants a decline leaf relative content, revealed severe growth inhibition, compared with 0% treatment. Under drought biomass stem was more noticeable than root for X32,...
Kinesin family member 2C (KIF2C) is known as an oncogenic gene to regulate tumor progression and metastasis. However, its pan-cancer analysis has not been reported. In this study, we comprehensively analyzed the characteristics of KIF2C in various cancers. We found that was highly expressed corresponded a poor prognosis also significant correlation between clinicopathological characteristics, particularly cervical cancer, which most common gynecological malignancy second leading cause...
Abstract The emergence of multidrug resistance (MDR) in cancer cells has made many the currently available chemotherapeutic agents ineffective. However, mechanism involved mediating this effect is not yet fully understood. Here, we found overexpression type I insulin‐like growth factor receptor (IGF‐IR) established colorectal MDR cells. Specific siRNA IGF‐IR decreases cell proliferation, exert synergistic with anticancer drugs. downstream signaling IGF‐IR, PI3K/AKT pathway, was altered upon...
MiR-222 in glioma can regulate cell cycle progression and apoptosis. However, the relationship between miR-222 Wnt/β-catenin signaling pathway remains unknown. Here, we found that Dickkopf-2 gene (DKK2) was a direct target of by prediction analysis dual luciferase reporter assay. RNA interference silencing DKK2 proved overexpression led to constitutive activation β-catenin through inhibition expression cells. Furthermore, siRNA significantly inhibited tumorigenesis vivo. Finally, Western...
The E2F1 gene well known is its pivotal role in regulating the entry from G1 to S phase, while salvage antitumoral pathway which implicates it, especially absence of p53, not fully characterized. We therefore attempted identify up- and down-stream events involved activation E2F1-dependent pro-apoptotic pathway. For this purpose, a amonafide analogue, 7-d (2-(3-(2-(Dimethylamino)ethylamino)propyl)-6-(dodecylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione) was screened, exhibited high antitumor...
Inflammatory response is an essential part of optimal tissue-implant integration and the regeneration process. Due to their highly plastic properties, macrophages display phenotypic changes during inflammatory signaling. Investigating these on implant surfaces for evaluating stability longevity. In order control macrophage polarization, IL-4 was conjugated titanium dioxide nanotubes (TNTs) through polydopamine, successful fabrication checked by scanning electron microscopy (SEM), atomic...
Erythropoietin-producing hepatoma receptor A2 (EphA2), tyrosine kinase, the most widespread member of largest kinase family, plays a critical role in physiological and pathological conditions. In recent years, EphA2 occurrence development cancer has become research hotspot is considered promising potential target. Our previous studies have shown that an indisputable cancer-promoting cervical cancer, but its related mechanism requires further research. this study, high-throughput sequencing...
Endometrial cancer, one of the common gynecological malignancies, is affected by several influencing factors. This study established a unique patient-derived orthotopic xenograft (PDOX) nude mouse model for factors in ER positive endometrial cancer. The aim this was to demonstrate that high-fat diet can affect growth cancer PDOX tumors. tumor tissues were expanded subcutaneous transplantation mice, and then orthotopically implanted into uterus establish model. After modeling, they divided...