A5006067740- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Ginseng Biological Effects and Applications
- Tryptophan and brain disorders
- Cancer survivorship and care
- Medicinal Plant Pharmacodynamics Research
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
Shanghai University of Traditional Chinese Medicine
2016-2025
Ministry of Agriculture and Rural Affairs
2022-2025
China Agricultural University
2019-2025
Shanghai Traditional Chinese Medicine Hospital
2025
Shanghai University
2012-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2014-2023
Los Alamos National Laboratory
2013
Tumor-associated macrophages (TAMs) play a critical role in modulating the tumor microenvironment and promote metastases. Our studies have demonstrated that ginsenoside Rh2 (G-Rh2), monomeric compound extracted from ginseng, is promising anti-tumor agent lung cancer cells. However, it remains unclear whetherG-Rh2 can modulate differentiation of TAMs its interaction with microenvironment. In this study, we investigated how G-Rh2 regulates phenotype affects migration non-small cell (NSCLC)...
Combining chemotherapy and immunotherapy is a promising strategy for the treatment of non-small cell lung cancer (NSCLC) metastasis. However, platinum-based chemotherapeutics immune checkpoint blockade-based have toxic side effects limitations. Ursolic acid (UA) astragaloside IV (AS-IV) are natural compounds with anticancer activity sourced from Traditional Chinese medicine (TCM). their poor water solubilities targeted deletions limit medicinal value. In this study, we fabricated hyaluronic...
Circulating tumor cells (CTCs) have been described as a population of that may seed metastasis, which is reliable target for the prevention metastases in lung cancer patients at early stage. The culturing CTCs vitro can be used to study mechanism metastasis and screen antimetastasis drugs. This aims establish CTC cell line explore potential its metastasis. A mixture EpCAM- EGFR-coated immunomagnetic microbeads microfluidic Herringbone-Chip was capture CTCs. CTCs, 95-D A549 evaluated by...
Ethnopharmacological relevance: Sanguinarine (SAG), a natural benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis Linn. (Bloodroot), possesses potential anticancer activity. Lung carcinoma is chief cause malignancy-related mortality in China. Non-small cell lung (NSCLC) main subtype and accounts for about eighty-five percent this disease. Current treatment controlling curing NSCLC remains deficient.The role underlying mechanism SAG repressing growth metastasis were...
The high glucose uptake and activation of oncogenic signaling pathways in cancer cells has long made these features, together with the mutational spectrum, prime diagnostic targets circulating tumor (CTCs). Further, an ability to characterize properties at a single cell resolution is widely believed be essential, as known extensive heterogeneity CTCs can obscure important correlations data obtained from population-based methods. However, date, it not been possible quantitatively measure...
Ferroptosis, a type of iron-dependent oxidative cell death caused by excessive lipid peroxidation, is emerging as promising cancer therapeutic strategy. Solasonine has been reported potential compound in tumor suppression, which closely linked to ferroptosis. However, ferroptosis solasonine insufficiently identified and elaborated lung adenocarcinoma, fatal disease with high morbidity mortality rates. First, the biochemical morphological changes Calu-1 A549 cells exposed are observed using...
Circulating tumor cells (CTCs) are that detach from the primary and enter bloodstream, playing a crucial role in metastasis of lung cancer. Unfortunately, there is currently lack drugs specifically designed to target CTCs prevent metastasis. In this study, we present evidence polyphyllin VII, potent anticancer compound, effectively inhibits cancer by inducing process called anoikis CTCs. We observed VII had significant cytotoxicity inhibited colony formation, migration, invasion both our...
Abstract Background Drug resistance in metastatic lung cancer significantly contributes to patient mortality. This study explores the role of circulating tumor cells (CTCs), precursors metastasis, driving this resistance. We aim delineate unique biological traits CTC clusters and elucidate mechanisms underlying their chemotherapy. Methods used an ultralow adsorption plate establish a suspension culture system. Comparisons between adherent cultures CTC-TJH-01 were made via Cell Counting Kit-8...
The CRISPR/Cas system is a sizable family that currently popular and efficient gene editing tool. Cas12i3, as member of the Type V-I family, has characteristics recognizing T-rich PAM sequences being guided by shorter crRNA higher efficiency than Cas9 in rice. However, potential tool accelerating breeding process, application Cas12i3 mammalian embryos not yet been reported. Our study systematically evaluated feasibility applying CRISPR/Cas12i3 to mouse embryos, with core pluripotency...
ABSTRACT TME is a core player in the development of cancerous lesion, immune evasive potential and its response to therapy. Sphingolipid metabolism, which governs number cellular processes, has been recognised as involved control heterogeneity within TME. metabolism‐related genes prevalent LUAD LUSC were identified using transcriptomic analysis clinical samples from TCGA GTEx databases. Lasso regression survival SVM Etra Application employed machine learning algorithms determine patient...
We describe a one-step microfludics-based immunomagnetic isolation method to isolate CTCs directly from the whole blood of lung adenocarcinoma patients. This avoids harsh sample preparation and enrichment steps, therefore preserves viability during in vitro isolation. Importantly, isolated, magnetic bead-bearing are concentrated small volume culture medium with high CTC density. High cell culturing density promote ex vivo expansion limited numbers CTCs. Expanded characterized at genetic,...
Background: Lung cancer is one of the most common causes cancer-related deaths worldwide, metabolic disorders are also a problem that puzzles mankind. SREBP overexpressed in non-small-cell lung (NSCLC) and key regulator lipid synthesis. However, mechanisms by which regulates proliferation, migration invasion NSCLC remain unclear. Materials Methods: CCK-8, colony formation assay, soft agar scratch wound healing assay transwell assays were performed to detect cells, respectively. In addition,...
Knocking down the oncogene ROC1 with siRNA inhibits proliferation of cancer cells by suppressing Neddylation pathway. However, methods for delivering in vivo to induce this high anticancer activity low potential side effects are urgently needed. Herein, a folic acid (FA)-modified polydopamine (PDA) nanomedicine used photothermal therapy was designed delivery. The nanovector can undergo conversion good biocompatibility. Importantly, genetic selectively delivered liver FA through...
Tumor-associated macrophage (TAM)-mediated angiogenesis in the tumor microenvironment is a prerequisite for lung cancer growth and metastasis. Therefore, targeting TAMs, which block angiogenesis, expected to be breakthrough controlling metastasis of cancer. In this study, we found that Sanguinarine (Sang) inhibits subcutaneously transplanted tumors Lewis mice. Furthermore, inhibited proliferation, migration, lumen formation HUVECs expression CD31 VEGF by regulating polarization M2...
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propensity for metastasis. Patients diagnosed with localized primary have higher survival rates than those Thus, it is imperative discover biomarkers the early detection NSCLC and timely prediction tumor metastasis improve patient outcomes.
Abstract Background Traditional Chinese medicine (TCM) is a widely applied complementary therapy for cancer patients. It can reduce the chemical drugs induced toxic effects to improve quality of life (QOL). This study applies highest clinical trial methodology examine role TCM in improving QOL postoperative non-small-cell lung Methods and design multi-center, randomized, placebo-controlled, double-blind trial. Four hundred eighty patients will be recruited into seven different research...
Non‑small cell lung cancer (NSCLC) is the leading cause of cancer‑associated mortality. Recent studies revealed that long non‑coding (lnc)RNAs have crucial roles in human cancers. The present study was first, to best our knowledge, indicate lncRNA transducer ERBB2, 1‑antisense 1 (TOB1‑AS1) acts as a tumor suppressor NSCLC. Knockdown TOB1‑AS1 significantly induced NSCLC migration, invasion and proliferation. It also demonstrated higher expression samples associated with longer overall...
To explore the effect of long-term traditional Chinese medicine (TCM) treatment on survival time colorectal cancer (hereinafter referred to as CRC).Our clinical study included patients who were diagnosed with CRC clinically or pathologically. Patients divided into TCM group and control according whether modified Anti-cancer Decoction II Formula was applied for more than six months. Propensity score matching PSM) used further balance covariates between groups. One-year six-year...