A5101408754- NF-κB Signaling Pathways
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Plant and Fungal Interactions Research
- T-cell and Retrovirus Studies
- Plant-Microbe Interactions and Immunity
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Cytokine Signaling Pathways and Interactions
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
- Winter Sports Injuries and Performance
- Lipid metabolism and disorders
- Spondyloarthritis Studies and Treatments
- Resilience and Mental Health
First Affiliated Hospital of Jinan University
2014-2024
Zhejiang University
2024
Northwest A&F University
2022-2023
Shandong University
2022
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2020
Shanghai University of Traditional Chinese Medicine
2020
North China University of Science and Technology
2017-2019
Bengbu Medical College
2017
Jinan University
2014
Huazhong Agricultural University
2013
Systemic immune-inflammation index as a useful prognostic indicator predicts survival in patients with advanced gastric cancer treated neoadjuvant chemotherapy Li Chen,1,* Ying Yan,2,* Lihua Zhu,3 Xiliang Cong,1 Sen Li,1 Shubin Song,1 Hongjiang Yingwei Xue1 1Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, University, Harbin, Heilongjiang, 2Department Internal Oncology, The First 3Department Pathogen Biology, School Basic Sciences, North China Science and...
Summary Small RNAs (sRNAs) play important roles in various biological processes by silencing their corresponding target genes most eukaryotes. However, cross‐kingdom regulation mediated fungal microRNA‐like (milRNAs) plant–pathogen interactions is still largely unknown. Using molecular, genetic, histological, and biochemical approaches, we found that the apple tree Valsa canker pathogen mali milRNA Vm ‐milR1 could suppress host immunity two receptor‐like kinase genes, MdRLKT1 MdRLKT2 . was...
There are a number of studies regarding to the susceptibility A20 SNPs in rheumatoid arthritis (RA); however, few these have shown an association between polymorphisms gene and RA risk Chinese population. The aim this study was investigate characteristics polymorphisms, clinical significance patients.PCR sequencing were used identify peripheral blood mononuclear cells (PBMCs) (50 cases), synovial fluid (11 cases) from patients PBMCs 30 healthy individuals. Quantitative Real-time PCR...
Currently, precise predictors in gastric cancer patients undergoing neoadjuvant chemotherapy are lacking. The study aims to investigate the prognostic value of monocyte lymphocyte ratio (MLR) with advanced receiving S-1 plus oxaliplatin (SOX) or and capecitabine (XELOX) regimen.The data from Harbin Medical University Cancer Hospital August 2008 September 2015 were retrospectively collected. Ninety-one treated included. blood samples collected before chemotherapy. MLR was divided into two...
Background: Inflammation plays an important role in tumor progression. Predicting survival is remarkably difficult patients with gastric cancer receiving neoadjuvant chemotherapy. The aim of the present study to investigate potential prognostic significance platelet-to-lymphocyte ratio S-1 plus oxaliplatin or and capecitabine regimen. Methods: Ninety-one treated chemotherapy were enrolled this then underwent operation. optimal cutoff value was calculated using receiver-operating...
Restricted T-cell receptor (TCR) Vα/Vβ repertoire expression and clonal expansion of αβ T cells especially for putative tumor-associated antigens were observed in patients with hematological malignancies. To further characterize the γδ immune status B-cell non-Hodgkin lymphoma (B-NHL), we investigated distribution clonality TCR Vγ/Vδ peripheral blood (PB), bone marrow (BM), lymph node (LN) from B-NHL. Four newly diagnosed B-NHL cases, including three diffuse large (DLBCL) one small...
Background: Accurate and useful predictors of gastric carcinoma treated with neoadjuvant chemotherapy are lacking at present. We aim to explore the potential prognostic significance neutrophil-to-lymphocyte ratio (NLR) in advanced cancer receiving S-1 plus oxaliplatin (SOX) or capecitabine (XELOX) regimen. Methods: enrolled 91 patients from August 2008 September 2015. The peripheral venous blood samples were collected before chemotherapy. NLR was divided into two groups: low <2.17 group high...
Recently mouse models have shown that expression of costimulatory molecules such as B7–1 on tumor cells can induce tumor-specific immunity, suggesting modified to express be a potential vaccine. To investigate the importance co-stimulation in induction autologous immunity humans, we established renal carcinoma cell line, RCC-1, from resection and studied patient's antitumor immune responses vitro. The RCC-1 line con-stitutively expressed major histocompatibility complex (MHC) class I,...
A20 is a repressor of NF-κB and was recently shown to be frequently inactivated by deletions or mutations in several types lymphomas including T-cell lymphoma. Little known about the characteristics acute lymphoblastic leukemia (T-ALL). In this study, we analyzed polymorphisms characterized their features 11 cases with T-ALL, 30 samples from healthy Chinese individuals, 3 cells lines CCRF-CEM, Molt-4, Toledo cells. Two frequent were found: CCT deletion at position 12384 nucleotide exchange...
Effectors play important roles in facilitating the infection of plant pathogenic fungi. However, gene expression regulatory mechanism effector genes, particular at post-transcriptional level, is largely unknown. In this study, we uncovered regulation an VmSP1 by a miRNA-like RNA (Vm-milR16) apple tree Valsa canker pathogen mali. Genetic and molecular biological assays indicated that could be suppressed Vm-milR16-mediated mRNA cleavage sequence-specific manner. During V. mali infection,...
Background: There have been several studies regarding the susceptibility of A20 gene SNPs (rs2230926 and rs5029937) in rheumatoid arthritis (RA).However, little is known about association between polymorphisms promoter RA.The aim this study was to investigate characteristics these clinical significance Chinese RA patients.Methods: PCR sequencing were used identify peripheral blood mononuclear cells (PBMCs) from 123 cases 31 healthy individuals.Results: Only one SNP (rs5029924) identified...
Emerging evidence demonstrates that the stromal derived factor-1 (SDF-1α)/CXCR4 axis is associated with tumor aggressiveness and metastasis, including glioma, most common brain cancer. In present study, we demonstrated a novel designed peptide NT21MP of viral macrophage inflammatory protein II, targeting CXCR4 inhibits SDF-1α-induced activation in glioma. The effects on expression, cell survival migration were assessed human glioma line U251 SHG-44 exposed to SDF-1α, by western blotting, MTT...
Abstract Background It is imperative to explore potential biomarkers for predicting clinical outcome and developing targeted therapies T‐cell acute lymphoblastic leukemia (T‐ALL). This study aimed investigate the mutation patterns of tumor necrosis factor‐alpha‐inducing protein 3 ( TNFAIP3 , also known as A20 ) its role in prognosis T‐ALL patients. Methods Polymerase chain reaction (PCR) Sanger sequencing data from n = 49, JNU) 54, NFH) our center a publicly available dataset 121,...
Abstract Aim An increased risk for malignancy rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients may be related to factors that play a critical role in the regulation of T‐cell activation. A20 is an important negative immunoregulatory factor was found associated with lymphoma development numerous solid tumors. Previous studies have implicated locus RA susceptibility. In this study, we investigated polymorphisms 3′ UTR explored whether there association between these...
Abstract Background T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it worth exploring biomarkers that may predict clinical outcomes investigate their potential role in developing targeted therapies. In this study, we characterized the mutation pattern of tumor necrosis factor-alpha-inducing protein 3 ( TNFAIP3 ) its prognosis TCL patients. Methods Coding sequence (CDS) mutations patients was explored using exome-sequencing data from 79 our center (Guangdong...
Abstract Background The comprehensive genetic alterations underlying the pathogenesis of Sézary syndrome (SS) remains largely unknown. Previous studies showed that tumor necrosis factor‐α‐induced protein 3 gene ( TNFAIP3 ; A20 ) are frequent in SS. In this study, we characterized mutation and polymorphisms a case with SS compared feature T‐cell acute lymphoblastic leukemia (T‐ALL). Methods Using novel approach based on combination fine‐tiling array comparative genomic hybridization...
Until now, there are still few comparisons between neoadjuvant immunochemotherapy and chemotherapy as first-line treatment for patients with stage IB-IIIB lung squamous cell carcinoma (LUSC). In addition, the ability of pathologic response to predict long-term survival has not been established. this retrospective, controlled clinical trial, we ultimately enrolled 231 IB IIIB LUSC who received 2-4 cycles perioperative or alone, followed by resection. The primary endpoint study was...
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