A5101533992- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Extracellular vesicles in disease
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Retinoids in leukemia and cellular processes
- Plant biochemistry and biosynthesis
- Cancer Cells and Metastasis
- Nerve injury and regeneration
- Cytokine Signaling Pathways and Interactions
- Allelopathy and phytotoxic interactions
- Cell Adhesion Molecules Research
- Curcumin's Biomedical Applications
- Immune cells in cancer
- RNA Research and Splicing
Bengbu Medical College
2014-2025
Hubei University of Chinese Medicine
2020-2024
Anhui Medical University
2024
University of Turku
2023
Oregon Health & Science University
2023
Fox Chase Cancer Center
2023
Dana-Farber Cancer Institute
2023
University of Helsinki
2023
Novartis (Switzerland)
2023
Soochow University
2016
Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not carcinomas, the most common human cancers. Here, we report t(2;3)(q13;p25), a translocation identified subset of thyroid follicular results DNA binding domains transcription factor PAX8 to A F peroxisome proliferator–activated receptor (PPAR) γ1. PAX8-PPARγ1 mRNA protein were detected 5 8 carcinomas 20 adenomas, 10 papillary or multinodular hyperplasias....
Most gastrointestinal stromal tumors (GISTs) express constitutively activated mutant isoforms of KIT or kinase platelet-derived growth factor receptor alpha (PDGFRA) that are potential therapeutic targets for imatinib mesylate. The relationship between mutations in these kinases and clinical response to was examined a group patients with advanced GIST.
Curcumin (Cur) has been widely used in medicine, due to its antibacterial, anti-inflammatory, antioxidant, and antitumor effects. However, clinic application is limited by instability poor solubility. In the present wok, curcumin was loaded into solid lipid nanoparticles (SLNs), order improve therapeutic efficacy for breast cancer. The results measured using transmission electron microscopy (TEM) indicated that Cur-SLNs have a well-defined spherical shape; size about 40 nm with negative...
In this study, resveratrol-loaded solid lipid nanoparticles (Res-SLNs) were successfully designed to treat MDA-MB-231 cells. The Res-SLNs prepared using emulsification and low-temperature solidification method. spherical, with small size, negative charge, narrow size distribution. Compared free resveratrol, the displayed a superior ability in inhibiting proliferation of addition, exhibited much stronger inhibitory effects on invasion migration Western blot analysis revealed that could...
Abstract MicroRNAs (miRNAs) have been identified as major post-transcriptional regulators of the initiation and progression human cancers, including breast cancer. However, detail role miR-451 has not fully elucidated in In this study, we aimed to investigate biological molecular mechanisms drug resistance cancer cell lines xenograft model. We show that is decreased specimens paclitaxel-resistant (PR) cells. Ectopic expression could inhibit migration invasion, promoted apoptosis, induced...
// Qingling Yang 1,* , Yangyang Wang 2,* Xiaohui Lu Zunlan Zhao 2 Lihua Zhu Sulian Chen 1 Qiong Wu 3 Changjie and Zhiwei 4 Department of Biochemistry Molecular Biology, Bengbu Medical College, Anhui, China Clinical Testing Diagnose Experimental Center Oncology, First Affiliated Hospital Bengbu, Cyrus Tang Hematology Center, Jiangsu Institute Hematology, Collaborative Innovation Soochow University, Suzhou, Jiangsu, * These authors contributed equally to this work Correspondence: Chen, email:...
Summary Artemisia argyi , as famous annua is a medicinal plant with huge economic value in the genus of and has been widely used world for about 3000 years. However, lack reference genome severely hinders understanding genetic basis active ingredient synthesis A. . Here, we firstly report complex chromosome‐level assembly large size 8.03 Gb, features high heterozygosity (2.36%), repetitive sequences (73.59%) number protein‐coding genes (279 294 total). The reveals at least three rounds...
Journal Article Multitarget-ribozyme directed to cleave at up nine highly conserved HIV-1 env RNA regions inhibits replication—potential effectiveness against most presently sequenced isolates Get access Chang-Jie Chen, Chen Laboratory of Viral and Molecular Pathogenesis, National Institute Neurological Disorders Stroke, Institutes HealthBethesda, MD 20892, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Akhil C. Banerjea, Banerjea George G. Harmison,...
Multidrug resistance (MDR) is a serious problem during cancer therapy. The purpose of the present study was to formulate D-α-Tocopheryl polyethylene glycol 1000 succinate-resveratrol-solid lipid nanoparticles (TPGS-Res-SLNs) improve its therapeutic efficacy against breast cancer. In this study, solvent injection method used prepare TPGS-Res-SLNs. It found that TPGS-Res-SLNs exhibited zeta potential and drug-loading −25.6 ± 1.3 mV 32.4 2.6%, respectively. Therefore, it evident can increase...
Although mitochondrial dysfunction has been observed in various types of human cancer cells, the molecular mechanism underlying mediated tumorigenesis remains largely elusive. To further explore function mitochondria and their involvement pathogenic mechanisms development, clones breast cells were generated by rotenone treatment, a specific inhibitor electron transport complex I. These verified respiratory defect measurement. Moreover, those exhibited increased reactive oxygen species (ROS),...
// Qiong Wu 1,* , Rui Wang Qingling Yang 2 Xin Hou 1 Sulian Chen Yueyue Changjie Yan Lucio Miele 4 Fazlul H Sarkar 5 Yuqing 3 Zhiwei 6,7 Department of Medical Oncology, First Affiliated Hospital Bengbu College, Bengbu, Anhui, China. Biochemistry and Molecular Biology, Respiration, University Mississippi Cancer Institute, Jackson, MS, USA Pathology Karmanos Wayne State University, Detroit, MI 6 Pathology, Beth Israel Deaconess Center, Harvard School, MA, 7 The Cyrus Tang Hematology Jiangsu...
// Rui Wang 1 , Yumei Li Yueyue Hou Qingling Yang 2 Sulian Chen Xi 3 Zishu Yan Changjie Zhiwei 4 Qiong Wu Department of Medical Oncology, First Affiliated Hospital Bengbu College, Bengbu, Anhui, China Biochemistry and Molecular Biology, The 117th PLA, Hangzhou, Cyrus Tang Hematology Center Collaborative Innovation Hematology, Jiangsu Institute the Hospital, Soochow University, Suzhou, Correspondence to: Wu, e-mail: qiongwu68@outlook.com Wang, zwang6@bidmc.harvard.edu Keywords: Hepatocellular...
Allelopathy is expressed through the release of plant chemicals and considered a natural alternative for sustainable weed management. Artemisia argyi (A. argyi) widely distributed throughout Asia, often dominates fields due to its strong allelopathy. However, mechanism A. allelopathy largely unknown need be elucidated at physiological molecular levels.In this study, we used electron microscopy, ionomics analysis, phytohormone profiling, transcriptome analysis investigate mechanisms using...
Autophagy is a cellular protective mechanism. As tumor cells are stimulated by drugs, autophagy activated to increase their resistance drugs. In gene regulation, microRNA (miRNA) plays vital role. The diagnostic and prognostic potential of various miRNAs in cancer has been recognized, for several years, miRNA-based therapeutic approaches have garnered significant interest the oncology field. RAB10, member RAB guanosine triphosphatase family, reported that it contributes chemotherapy....
Breast cancer is one of the most common cancers among women. Tumor cell proliferation highly dependent on aerobic glycolysis, so regulating glycolysis in breast cells a promising therapeutic strategy. Resveratrol (Res), as potential new anti-breast drug, has been shown to regulate and inhibit metastasis recurrence cancer. The nano drug delivery system can metabolism by targeting signaling factors reaction products tumor process enhance anti-tumor effect. A albumin-modified layered double...
Abstract Background Hepatocellular carcinoma (HCC) still is a big burden for China. In recent years, the third-generation platinum compounds have been proposed as potential active agents HCC. However, more experimental and clinical data are warranted to support proposal. present study, effect of lobaplatin was assessed in five HCC cell lines underlying molecular mechanisms terms cycle kinetics were explored. Methods Cytotoxicity human examined using MTT proliferation assay. Cell distribution...