A5081961039- Neuroscience and Neuropharmacology Research
- Mycorrhizal Fungi and Plant Interactions
- Plant Pathogens and Fungal Diseases
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Amino Acid Enzymes and Metabolism
- Yeasts and Rust Fungi Studies
- Lichen and fungal ecology
- Molecular Sensors and Ion Detection
- Fungal Biology and Applications
- Lipid Membrane Structure and Behavior
- Glycosylation and Glycoproteins Research
- Gastrointestinal Tumor Research and Treatment
- Botany and Plant Ecology Studies
- Mitochondrial Function and Pathology
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Advanced Chemical Physics Studies
- Pancreatic and Hepatic Oncology Research
- Vestibular and auditory disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Diabetic Foot Ulcer Assessment and Management
The University of Western Australia
2024
University of Helsinki
1977-2023
University of Turku
2002-2023
Oregon Health & Science University
2003-2023
Fox Chase Cancer Center
2003-2023
Dana-Farber Cancer Institute
2003-2023
Novartis (Switzerland)
2008-2023
University of Huddersfield
2011-2023
Rhodes University
2022-2023
Endangered Wildlife Trust
2023
Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis gastrointestinal stromal tumors. Imatinib mesylate, a selective inhibitor, has been shown preclinical models and preliminary clinical studies to have activity against such
Purpose: Most gastrointestinal stromal tumors (GISTs) express constitutively activated mutant isoforms of KIT or kinase platelet-derived growth factor receptor alpha (PDGFRA) that are potential therapeutic targets for imatinib mesylate. The relationship between mutations in these kinases and clinical response to was examined a group patients with advanced GIST. Patients Methods: GISTs from 127 enrolled onto phase II study were PDGFRA. Mutation types correlated outcome. Results: Activating...
Gastrointestinal stromal tumors are a group of mesenchymal neoplasms that arise from precursors the connective-tissue cells gastrointestinal tract.1 They occur predominantly in middle-aged and older persons, approximately 70 percent found stomach, 20 to 30 small intestine, less than 10 elsewhere Recent studies have shown express growth factor receptor with tyrosine kinase activity termed c-kit. This receptor, product proto-oncogene c-kit, can be detected by immunohistochemical staining for . . .
The outcome of patients diagnosed with advanced gastrointestinal stromal tumor (GIST) and treated long-term imatinib mesylate is unknown. A previous report a randomized phase II trial in incurable GIST detailed high response rates at both the 400 600 mg/d dose levels. We conducted analysis on trial, including followed during an extension phase, to evaluate survival, patterns failure, potential prognostic factors, mutational status.Patients were enrolled onto open-label, multicenter randomly...
Purpose Gastrointestinal stromal tumors (GISTs) commonly harbor oncogenic mutations of the KIT or platelet-derived growth factor alpha (PDGFRA) kinases, which are targets for imatinib. In clinical studies, 75% to 90% patients with advanced GISTs experience benefit from However, imatinib resistance is an increasing problem. Patients and Methods One hundred forty-seven advanced, unresectable were enrolled onto a randomized, phase II study Specimens pretreatment and/or imatinib-resistant...
Abstract— The effects of l ‐glutamate and a number structural analogues on the spontaneous release [ 3 H]dopamine from slices rat striatum were examined. Glutamate, other excitatory amino acids produced marked stimulation H]DA which was Ca 2+ ‐dependent unaffected by either procaine or tetrodotoxin. glutamate‐stimulated abolished in kainate‐lesioned striatum. action glutamate effectively antagonised glutamamate diethylester 2‐amino‐4‐phosphonobutyric acid, but only weakly ‐methionine‐ dl...
Most gastrointestinal stromal tumors (GISTs) express constitutively activated mutant isoforms of KIT or kinase platelet-derived growth factor receptor alpha (PDGFRA) that are potential therapeutic targets for imatinib mesylate. The relationship between mutations in these kinases and clinical response to was examined a group patients with advanced GIST.
• Here, the reliability of published fungal nucleic acid sequences is tested by critical re-evaluation 206 named obtained from public-access databases. Sequences ribosomal RNA (rRNA) gene cluster were examined as these are commonly used to establish phylogeny and evolution, also increasingly employed in identification fungi nonculture based studies. Fifty-one rRNA internal transcribed spacer (ITS) for species Amanita, 55 ITS Phoma 100 small subunit representative genera order Helotiales. In...
Abstract— l [ 3 H]glutamate binding was investigated in membrane preparations derived from rat cerebellum, an area of the brain where it is likely that a high density postsynaptic glutamate receptors occurs. Glutamate hound specifically and, freshly prepared membranes, optimal under physiological conditions pH and temperature associated with synaptic fraction cell. Specific occurred through single, high‐affinity process K D , 744 nM capacity 73 pmol/mg protein. Unlike findings reported for...
Serum CA 19-9 antigen concentrations were measured in 246 patients with benign and histologically confirmed malignant gastrointestinal diseases. The concentration was above the upper limit of normal range (0-37 U/ml) 76% pancreatic carcinoma, 73% cholangiocarcinoma, 42% gastric 22% hepatoma. High found mainly a metastasised cancer, whereas 71% localised carcinoma had concentrations. All diseases values. Moderately increased 15-36% pancreatic, liver, biliary tract alpha-fetoprotein better...
Abstract Strong expression of many matrix metalloproteinases (MMPs) has been related to poor survival colorectal cancer (CRC) patients. The tissue inhibitors (TIMPs) associated with both a beneficial and outcome there is thus need further clarify the significance MMPs TIMPs in CRC. prognostic 4 CRC was evaluated. Formalin‐fixed, paraffin‐embedded arrayed samples 351 patients primary colon or rectal Dukes' stages A‐D were selected for immunohistochemical staining MMP‐1, ‐2, ‐7 ‐13, TIMP‐1, ‐3...
Abstract: Destruction of the glutamatergic corticostriatal pathway potentiates neurotoxic action 1 μmol L‐glutamate injected into rat striatum, whereas toxic effects 10 nmol kainate are markedly attenuated. Injection 170 glutamate uptake inhibitor, DL‐threo‐3‐hydroxyaspartate, intact striatum also causes neuronal degeneration, which is accompanied by a reduction in markers for cholinergic and GABAergic neurones. Prior removal destroys ability DL‐threo‐3‐hydroxyaspartate to cause lesions...