A5100335697- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Immunodeficiency and Autoimmune Disorders
- NF-κB Signaling Pathways
- T-cell and Retrovirus Studies
- Retinoids in leukemia and cellular processes
- Cytokine Signaling Pathways and Interactions
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Immune cells in cancer
- RNA modifications and cancer
- Renal and related cancers
Jinan University
2015-2024
Guangxi Medical University
2020-2024
First Affiliated Hospital of Jinan University
2009-2024
First Affiliated Hospital of Bengbu Medical College
2018-2024
Beijing Institute of Technology
2024
First Affiliated Hospital of GuangXi Medical University
2020-2023
Fujian Medical University
2008-2023
Bengbu Medical College
2016-2023
Tumor Hospital of Guangxi Medical University
2023
Union Hospital
2023
Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17), which fuses PML with retinoic acid receptor alpha (RARα). Although PML-RARα crucially important for pathogenesis and responsiveness to treatment, molecular cellular mechanisms exerts its oncogenic potential have not been fully elucidated. Recent reports suggested that long non-coding RNAs (lncRNAs) contribute precise control of gene expression are involved in human diseases. Little known about role...
T cells are fundamental effector against viruses and cancers that can be divided into different subsets based on their long-term immune protection immediate response effects. The percentage absolute number of these change with ageing, which leads to a reduced in older individuals. Stem cell memory (TSCM) represent small population enhanced proliferation differentiation properties endowed high potential for maintaining homeostasis. However, whether ageing gender remains unknown. Here, we...
Acute promyelocytic leukemia (APL) is associated with chromosomal translocation t(15;17), which results in the proliferation of morphologically abnormal promyelocytes. Gain supernumerary copies 8q24 region, harbors MYC and PVT1, has been shown to be most common secondary alteration human APL. Increased can accelerate development myeloid However, role that expression long non-coding RNA (lncRNA) PVT1 plays pathogenesis APL remains largely unknown. In this study, we first analyzed lncRNA level...
Abstract Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the exhaustion T cells, and blockade PD-1 pathway an effective immunotherapeutic strategy for treating various cancers. However, response rates are limited, many patients do not achieve durable responses. Thus, it important to seek additional strategies that can improve anticancer immunity. Here, we report bromodomain extraterminal domain (BET) inhibitor JQ1 inhibits in Jurkat primary T-cell models....
To investigate the association between T cell inhibitory receptor programmed death 1 (PD-1) and exhaustion status in cells from patients with de novo acute myeloid leukemia (AML) AML complete remission (CR).Surface expression of PD-1 immunosenescence markers CD244 CD57 on CD3+, CD4+ CD8+ peripheral blood samples 20 newly diagnosed, untreated 10 cases CR was analyzed by flow cytometry. Twenty-three healthy individuals served as control.A significantly higher percentage PD-1+ were found for...
Abstract Background Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis leukemia patients which leukemic bone marrow (BM) microenvironment contribute to such immunosuppression. We found higher numbers programmed death-1 (PD-1) + exhausted cells peripheral blood (PB) from acute myeloid (AML) patients. To investigate BM influence on immunosuppression, we further compared distributions PD-1 immunoglobulin mucin-3 (Tim-3)...
Abstract Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4+ T cells. EAE classically presents with a progressive ascending paralysis and model multiple sclerosis that recapitulates some aspects disease. In this report we describe mouse strain spontaneously develops severe, nonclassical form 100% incidence. The distinct clinical phenotype marked initially slight head tilt, progressing to severe spinning, or rotatory motion....
The miR-29 family have been demonstrated acting as vital tumor suppressor in multiple cancers well regulators the adaptive immune system. Little is known about their role leukemogenesis. purpose of this study to analyze expression pattern miR-29a/29b and its target genes Mcl-1 (myeloid cell leukemia sequence 1) B-cell lymphoma 2 (Bcl-2) myeloid leukemia.Quantitative real-time PCR was used for detecting level peripheral blood mononuclear cells (PBMCs) from 10 cases with newly diagnosed,...
Despite the great success of immune-checkpoint inhibitor (ICI) treatment for multiple cancers, evidence clinical use ICIs in acute myeloid leukemia (AML) remains inadequate. Further exploration causes immune evasion bone marrow (BM) environment, primary site, and peripheral blood (PB) understanding how T cells are affected by AML induction chemotherapy or influence age may help to select patients who benefit from ICI treatment. In this study, we comprehensively compared distribution PD-1...
Abstract Parkinson's disease (PD) is a progressive neurodegenerative whose etiology attributed to development of Lewy bodies and degeneration dopaminergic neurons in the substantia nigra (SN). Currently, there are no definitive diagnostic indicators for PD. In this study, we aimed identify potential biomarkers PD analyzed impact immune cell infiltrations on pathogenesis. The expression profile data human SN tissue, GSE7621, GSE20141, GSE20159, GSE20163 GSE20164 were downloaded from Gene...
The diverse structural and functional heterogeneity of γδ T cells is related to their distinct role in cancer immunity. different phenotypes patients with acute myeloid leukemia (AML) far from clear. In particular, the expression pattern co-inhibitory co-stimulatory receptors on remains unknown. this study, we analyzed distribution cell subsets by immune checkpoint co-inhibitor TIGIT (T immunoglobulin immunoreceptor tyrosine-based inhibitory motif domain) its competing receptor CD226 AML...
To investigate the correlation between cluster of differentiation-44 (CD44) expression and immunotherapy response identify its possible predictive value in pan-cancer. Datasets 33 cancer types from The Cancer Genome Atlas (TCGA) database were applied to relationship CD44 with prognosis, tumor mutational burden (TMB), microsatellite instability (MSI), determine potential prognostic Patients split into high-risk low-risk groups based on survival outcomes various types. Additionally, underlying...
Lpar3 is upregulated in the preimplantation uterus, and deletion of leads to delayed uterine receptivity mice. Microarray analysis revealed that there was higher expression Col3a1 Col6a3 Preimplantation Day 3.5 Lpar3−/− uterus compared wild-type (WT) uterus. Since extracellular matrix (ECM) remodeling indispensable during embryo implantation, dynamic spatiotemporal alteration specific collagen types part this process, study aimed characterize four main types: fibril-forming (COL) I COL III,...
There are a number of studies regarding to the susceptibility A20 SNPs in rheumatoid arthritis (RA); however, few these have shown an association between polymorphisms gene and RA risk Chinese population. The aim this study was investigate characteristics polymorphisms, clinical significance patients.PCR sequencing were used identify peripheral blood mononuclear cells (PBMCs) (50 cases), synovial fluid (11 cases) from patients PBMCs 30 healthy individuals. Quantitative Real-time PCR...
Kruppel-like factor 4 (KLF4) induces tumorigenesis or suppresses tumor growth in a tissue-dependent manner. However, the roles of KLF4 hematological malignancies and mechanisms action are not fully understood. Inducible KLF4-overexpression Jurkat cell line combined with mouse models bearing cell-derived xenografts primary T-cell acute lymphoblastic leukemia (T-ALL) cells from four patients were used to assess functional role T-ALL vitro vivo. A genome-wide RNA-seq analysis was conducted...
Abstract Aim The immunosuppressive microenvironment plays a crucial role in T‐cell immunodeficiency multiple myeloma (MM). Overexpression of receptors, including programmed death‐1 (PD‐1) and immunoglobulin mucin‐domain‐containing‐3 (Tim‐3), may be related to tumor immunosuppression poor prognosis, the malignant bone marrow (BM) contribute such immunosuppression. purpose this study was analyze distribution PD‐1 + and/or Tim‐3 T cells different subset patients with MM. Methods expression...
Foxp3+ γδ regulatory T ( Treg) cells promote tumor growth by various mechanisms and induce immuno-senescence. The novel immune checkpoint coinhibitory receptor cell Ig ITIM domain (TIGIT) shares similar ligands as the costimulatory DNAX accessory molecule 1 (DNAM-1) suppresses responses in patients. This study is aimed at characterizing whether TIGIT/DNAM-1 axis involved distribution expression of Treg subsets acute myeloid leukemia (AML) patients different clinical statuses: de novo AML (27...
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subtype of with poor prognosis, and biomarkers novel therapeutic targets are urgently needed for this disease. Our previous studies have found that inhibition the B-cell leukemia/lymphoma 11B ( BCL11B ) gene could significantly promote apoptosis growth retardation T-ALL cells, but molecular mechanism underlying effect remains unclear. This study intends to investigate genes downstream further explore its function in cells....