A5087375932- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Polysaccharides and Plant Cell Walls
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- DNA Repair Mechanisms
- RNA Research and Splicing
- Ion Channels and Receptors
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Peroxisome Proliferator-Activated Receptors
- Circular RNAs in diseases
- Parkinson's Disease Mechanisms and Treatments
- Telomeres, Telomerase, and Senescence
- Hippo pathway signaling and YAP/TAZ
- Neurobiology and Insect Physiology Research
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Proteins in Food Systems
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Acupuncture Treatment Research Studies
- Mitochondrial Function and Pathology
- Drug Transport and Resistance Mechanisms
University of Science and Technology of China
2019-2025
Anhui Medical University
2015-2025
Changzhi Medical College
2025
Anhui Provincial Hospital
2025
Commercial Aircraft Corporation of China (China)
2024
Anhui Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Hubei University of Chinese Medicine
2023-2024
Wuhan University
2019-2024
Third People's Hospital of Hefei
2024
Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17), which fuses PML with retinoic acid receptor alpha (RARα). Although PML-RARα crucially important for pathogenesis and responsiveness to treatment, molecular cellular mechanisms exerts its oncogenic potential have not been fully elucidated. Recent reports suggested that long non-coding RNAs (lncRNAs) contribute precise control of gene expression are involved in human diseases. Little known about role...
Abstract Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading synapse dysfunction in Alzheimer’s disease (AD). In the present study, we report that probability (Pr) at between Schaffer collateral (SC) and CA1 pyramidal neurons significantly reduced an stage mouse models of AD with elevated Aβ production. High nanomolar synthetic oligomeric 42 also suppresses Pr SC-CA1 wild-type mice. This Aβ-induced suppression mainly due...
Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well pathological hallmarks, including dopaminergic (DA) neuron death formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), PD susceptibility gene identified through genome-wide association studies (GWAS), ubiquitous serine/threonine involved in clathrin uncoating, though its PD-related function remains elusive. Here, we implicate the Drosophila GAK...
Foraging food in a novel environment is essential for survival. Animals coordinate the complex motivated states and decide whether to initiate feeding or escape from unfamiliar scenes. Neurons paraventricular thalamic nucleus (PVT) receive multiple inputs hypothalamus, forebrain, caudal brainstem that are known regulate behavior. The PVT neurons also project forebrain regions involved reward motivation. Notably, projecting accumbens (NAc) activated when an incentive stimulus presented....
Abstract FUN14 domain containing 1 (FUNDC1) is an important molecule in receptor‐dependent mitophagy. However, the roles of FUNDC1 human cancer biology remain unknown. The aim this study was to explore expression and cervical cancer. Immunohistochemistry Western blotting were applied detect FUNDC1, small‐hairpin RNA inhibit endogenous cells. MTT assays Flow cytometric analysis examine cell proliferation apoptosis. Immunofluorescence used formation γH2AX foci evaluate extent DNA damage....
PurposeTelomerase is reactivated in non-small cell lung cancer (NSCLC), and it increases resistance to irradiation through protecting damaged telomeres enhancing DNA damage repair. We investigated the radiosensitizing effect of BIBR1532, a highly selective telomerase inhibitor, its corresponding mechanism NSCLC.Methods MaterialsCell proliferation, activity, telomere dysfunction-induced foci were measured with CCK-8 assay, real-time fluorescent quantitative polymerase chain reaction,...
Neonatal hypoxic-ischemic brain damage (HIBD), a leading cause of neonatal mortality, has intractable sequela such as epilepsy that seriously affected the life quality HIBD survivors. We have previously shown ion channel dysfunction in central nervous system played an important role process HIBD-induced epilepsy. Therefore, we continued to validate underlying mechanisms TRPV1 potential target for epilepsy.Neonatal hypoxic ischemia and oxygen-glucose deprivation (OGD) were used simulate vivo...
Epilepsy is a common brain disorder, repeated seizures of epilepsy may lead to series pathological changes such as neuronal or glial damage. However, whether circular RNAs are involved in injury during not fully understood. Here, we screened circIgf1r the status epilepticus model through circRNA sequencing, and found that it was upregulated after QPCR analysis. Astrocytes polarizing toward neurotoxic A1 phenotype neurons loss were observed epilepticus. Through injecting siRNA into lateral...
Telomerase, by safeguarding damaged telomeres and bolstering DNA damage repair, has the capacity to heighten radioresistance of tumour cells. Thus, in turn, can compromise efficacy radiotherapy (RT) radioimmunotherapy. Our previous studies have revealed that highly selective telomerase inhibitor, BIBR1532, possesses potential enhance radiosensitivity Non-small cell lung cancer (NSCLC). In this study, we delve further into impact BIBR1532 on immune activation induced RT elucidate underlying...
Immunosuppressive phenotype compromised immunotherapy efficacy of hepatocellular carcinoma. Tumor cells intrinsic mitochondria dynamics could pass effects on the extracellular microenvironment through mtDNA stress. PGAM5 anchors at and regulates functions. We aim to explore whether regulation tumor-intrinsic affects tumor-infiltrating immune in can be a therapeutic target enhance carcinoma (HCC). analyzed correlation expression infiltration using Gene Expression Omnibus (GEO) The Cancer...
Background: Parkinson's disease (PD) represents a prevalent neurodegenerative condition that leads to significant disability and contributes growing public health challenge worldwide. However, comprehensive report on progress from 1990 2021 is still lacking, especially regarding the risk factors associated with PD by gender age. This study aims examine patterns of incidence, mortality rates, disability-adjusted life years (DALYs) across all age groups, along linked PD-related fatalities,...
Abstract Hepatocellular carcinoma (HCC) is the one of most common and deadly cancers, also highly resistant to conventional chemotherapy treatments. Mitochondrial phosphoglycerate mutase/protein phosphatase (PGAM5) regulates mitochondrial homeostasis cell death, however, little known about its roles in cancer. The aim this study was explore clinical significance potential biological functions PGAM5 hepatocellular carcinoma. For first time, our results show that significantly upregulated HCC...
Abstract The development of dietary fibers as safe and effective food additives or nutrients for preventing alleviating inflammatory bowel disease (IBD) is increasingly important. β ‐glucans, renowned prebiotics, have shown promise in IBD symptoms by modulating gut flora diversity repairing the intestinal barrier. Auricularia auricula‐judae , an edible fungus, contains a ‐glucan with triple‐helical structure polysaccharide from black fungus (BFP), which exhibits unique sol–gel properties....
Fenofibrate is widely used in clinical practice, but its influence on chronic endoplasmic reticulum (ER) stress induced by feeding a high-calorie and high-cholesterol diet (HCD) has still not been studied. We thus investigated effects the liver of nonalcoholic fatty disease (NAFLD) mouse model. Male C57BL/6 mice fed an HCD for 3 months were treated with fenofibrate (HCD + FF, 40 mg/kg, once daily) via gavage 4 weeks. Insulin sensitivity, serum lipid inflammatory cytokines measured. Liver...
Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma (ESCC). NS1-binding protein (NS1-BP), member of the BTB-kelch family, has been shown to inhibit proliferation Hela cells by suppressing c-Myc. In present study, we examined potential function role NS1-BP expression in ESCC, and particularly, sensitivity ESCC radiotherapy.NS1-BP was using immunohistochemistry two cohorts (n = 98 training cohort; n 46 independent...