A5101438534- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Distributed Control Multi-Agent Systems
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Lipid metabolism and biosynthesis
- Hippo pathway signaling and YAP/TAZ
- Network Security and Intrusion Detection
- Reinforcement Learning in Robotics
- Adaptive Dynamic Programming Control
- Ferroptosis and cancer prognosis
- Technology and Security Systems
- Genomics and Phylogenetic Studies
University of Science and Technology of China
2014-2025
Anhui Provincial Hospital
2025
This article presents an off-policy model-free algorithm based on reinforcement learning (RL) to optimize the fully cooperative (FC) consensus problem of nonlinear continuous-time multiagent systems (MASs). First, optimal FC is transformed into solving coupled Hamilton-Jacobian-Bellman (HJB) equation. Then, we propose a policy iteration (PI)-based algorithm, which further proved be effective solve HJB To implement this scheme in way, Bellman equation derived find value function and control...
Immunosuppressive phenotype compromised immunotherapy efficacy of hepatocellular carcinoma. Tumor cells intrinsic mitochondria dynamics could pass effects on the extracellular microenvironment through mtDNA stress. PGAM5 anchors at and regulates functions. We aim to explore whether regulation tumor-intrinsic affects tumor-infiltrating immune in can be a therapeutic target enhance carcinoma (HCC). analyzed correlation expression infiltration using Gene Expression Omnibus (GEO) The Cancer...
Abnormal alternative splicing (AS) contributes to aggressive intrahepatic invasion and metastatic spread, leading the high lethality of hepatocellular carcinoma (HCC). This study aims investigate functional implications UPF3B-S (a truncated oncogenic splice variant) in HCC metastasis. Basescope assay was performed analyze expression mRNA tissues cells. RNA immunoprecipitation, vitro vivo models were used explore role underlying mechanisms. We show that factor HnRNPR binds pre-mRNA UPF3B via...
Abstract Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH, EC: 1.2.1.12) is an essential enzyme in the glycolytic pathway. However, recent evidence demonstrates that GAPDH displays a range of new functions unrelated to its function. has long been known as 3′ AU‐rich element‐binding protein; however, RNA recognition mechanism still not well understood. Here, we present first crystal structure GAPDH3 from Saccharomyces cerevisiae and identify RNA‐binding specificity propose model based on...