A5090046952- Ion Channels and Receptors
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Cancer Research and Treatments
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- Aldose Reductase and Taurine
- Natural product bioactivities and synthesis
- Receptor Mechanisms and Signaling
- Neonatal and fetal brain pathology
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Ethnobotanical and Medicinal Plants Studies
- Neurobiology and Insect Physiology Research
- Polysaccharides Composition and Applications
- Hippo pathway signaling and YAP/TAZ
- Immunodeficiency and Autoimmune Disorders
- Cellular transport and secretion
Wuhan University
2004-2024
Guizhou University
2023
Wuhan Donghu University
2022
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2009
Zhongnan Hospital of Wuhan University
2004
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome considered an important regulator of immunity and inflammation, both which play critical role MS. However, underlying mechanism activation not fully understood. Here we identified that TRPV1 (transient receptor potential vanilloid type 1) channel microglia, as Ca2+ influx-regulating channel, played activation. Deletion or pharmacological blockade inhibited...
Neonatal hypoxic-ischemic brain damage (HIBD), a leading cause of neonatal mortality, has intractable sequela such as epilepsy that seriously affected the life quality HIBD survivors. We have previously shown ion channel dysfunction in central nervous system played an important role process HIBD-induced epilepsy. Therefore, we continued to validate underlying mechanisms TRPV1 potential target for epilepsy.Neonatal hypoxic ischemia and oxygen-glucose deprivation (OGD) were used simulate vivo...
Epilepsy is a common brain disorder, repeated seizures of epilepsy may lead to series pathological changes such as neuronal or glial damage. However, whether circular RNAs are involved in injury during not fully understood. Here, we screened circIgf1r the status epilepticus model through circRNA sequencing, and found that it was upregulated after QPCR analysis. Astrocytes polarizing toward neurotoxic A1 phenotype neurons loss were observed epilepticus. Through injecting siRNA into lateral...
A physiological membrane-receptor agonist typically stimulates oscillations, of varying frequencies, in cytosolic Ca2+ concentration ([Ca2+]i). Whether and how [Ca2+]i oscillation frequency regulates agonist-stimulated downstream events, such as gene expression, non-excitable cells remain unknown. By precisely manipulating histamine-stimulated vascular endothelial (ECs), we demonstrate that the expression cell adhesion molecule 1 (VCAM1) critically depends on presence, well absence,...
Epilepsy is a chronic neurological disorder whose pathophysiology relates to inflammation. The potassium channel Kv1.3 in microglia has been reported as promising therapeutic target diseases which neuroinflammation involved, such multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's (PD), and middle cerebral artery occlusion/reperfusion (MCAO/R). Currently, little known about the relationship between epilepsy. In this study, we found that was upregulated KA-induced mouse epilepsy...
The astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity brain region-specific pattern. Functional alterations of reactive are commonly present human temporal lobe epilepsy (TLE) cases, meanwhile neuroinflammation mediated by may advance development hippocampal animal models. Nuclear factor I-A (NFIA) regulate astrocyte adult brain. However, whether NFIA endows with regional specificity to be involved epileptogenesis remains elusive.Here, we utilize...
Abstract Background Accumulating evidence suggests that disease-associated microglia (DAM), a recently discovered subset of microglia, plays protective role in neurological diseases. Targeting DAM phenotypic transformation may provide new therapeutic options. However, the relationship between and epilepsy remains unknown. Methods Analysis public RNA-sequencing data revealed predisposing factors (such as dipeptidyl peptidase IV; DPP4) for related to conversion. Anti-epileptic effect was...
Hypoxic-ischemic brain damage (HIBD) is a leading cause of neonatal mortality, resulting in injury and persistent seizures that can last into the late period beyond. Effective treatments interventions for infants affected by hypoxia-ischemia remain lacking. Clinical investigations have indicated an elevation nuclear factor activated T cells 5 (NFAT5) whole blood from umbilical cords severely HIBD with epilepsy. Experimental research has demonstrated NFAT5 ambivalent effects on...
To investigate the association between store-operated Ca 2+ entry (SOCE) and reactive oxygen species (ROS) during hypoxia, this study determined changes of transient receptor potential canonical 1 (TRPC1) Orai1, two candidate proteins for (SOC) channels their gate regulator, stromal interaction molecule (STIM1), in a hypoxic environment relationship with ROS pulmonary arterial smooth muscle cells (PASMCs). Exposure to hypoxia caused spike subsequent plateau SOCE be intensified PASMCs when...
Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with severe long-term sequelae such as cerebral palsy, epilepsy and cognitive disabilities. Na+-K+-2Cl- cotransporters 1 (NKCC1) dramatically upregulated after hypoxia-ischemia (HI), which aggravates brain edema damage. Clinically, an NKCC1-specific inhibitor, bumetanide, used to treat diseases related aberrant NKCC1 expression, but the underlying mechanism of expression has rarely been studied in HIE. In this study,...
The mechanisms by which mitochondria regulate the sustained phase of agonist-induced responses in cytosolic Ca(2+) concentration as an independent organelle whole is not clear. By exposing to ethidium bromide and supplying pyruvate uridine, we established mitochondrial DNA (mtDNA)-depleted rat airway smooth muscle cells (RASMCs) with maintained cellular energy. Upon exposure 2 microM histamine, [Ca(2+)](i) control RASMCs increased a peak followed plateau above baseline, whereas...
Background: Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with severe long-term sequelae such as cerebral palsy, epilepsy and cognitive disabilities. Na+-K+-2Cl− cotransporters 1 (NKCC1) dramaticly upregulated after hypoxic-ischemia (HI) which aggravates brain edema damage. Clinically, NKCC1 specific inhibitorbumetanide was used to treat diseases related aberrant expression, but the underlying mechanism of expression hardly studied in HIE.Methods: Immunofluorescence,...
Two new dihydro-β-agarofuran sesquiterpenes chiapen T (1) and U (2), along with A (3), 1β-hydroxy-2β,6α,12-triacetoxy-8β-(β-nicotinoyloxy)-9β-(benzoyloxy)-β-dihydroagarofuran (4), wilforlide B (5), 3-hydroxy-2-oxo-3-friedelen-29-oic acid (6), epikatonic (7), 22-epi-maytenfolic (8), maytenoic (9), wilforic F (10), (11), were reported for the first time from Celastrus angulatus. The structures of all compounds elucidated by HR-ESI-MS, 1 D 2 NMR spectra, as well single-crystal X-ray diffraction...