A5100705240- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Graphene research and applications
- Crystallography and molecular interactions
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Catalytic C–H Functionalization Methods
- MicroRNA in disease regulation
- Organic Light-Emitting Diodes Research
- Advanced Nanomaterials in Catalysis
- Circular RNAs in diseases
- Covalent Organic Framework Applications
- Microbial Metabolic Engineering and Bioproduction
- 2D Materials and Applications
- Ecology and Vegetation Dynamics Studies
- Electrochemical sensors and biosensors
- Biosensors and Analytical Detection
- Topological Materials and Phenomena
- Metalloenzymes and iron-sulfur proteins
- Quantum and electron transport phenomena
- Electrochemical Analysis and Applications
- Glycosylation and Glycoproteins Research
Chinese Academy of Sciences
2007-2025
Tianjin Institute of Industrial Biotechnology
2024-2025
Dalian Institute of Chemical Physics
2020-2025
China Agricultural University
2024-2025
Dalian Polytechnic University
2023-2025
Johns Hopkins University
2023-2025
Lanzhou University
2015-2024
University of Science and Technology of China
1998-2024
Zhejiang A & F University
2024
Agriculture and Forestry University
2024
Relationships between biodiversity and multiple ecosystem functions (that is, multifunctionality) are context-dependent. Both plant soil microbial diversity have been reported to regulate multifunctionality, but how their relative importance varies along environmental gradients remains poorly understood. Here, we relate multifunctionality across 130 dryland sites a 4,000 km aridity gradient in northern China. Our results show strong positive association species richness less arid regions,...
Abstract Exosomes hold great potential in therapeutic development. However, native exosomes usually induce insufficient effects vivo and simply act as drug delivery vehicles. Herein, we synthesize responsive exosome nano‐bioconjugates for cancer therapy. Azide‐modified derived from M1 macrophages are conjugated with dibenzocyclooctyne‐modified antibodies of CD47 SIRPα (aCD47 aSIRPα) through pH‐sensitive linkers. After systemic administration, the can actively target tumors specific...
ABSTRACT Multiple sclerosis (MS) is a chronic disease that characterized by demyelination and axonal damage in the central nervous system. Cognitive deficits are recognized as one of features MS, these affect patients’ quality life. Increasing evidence from experimental autoimmune encephalomyelitis (EAE), animal model has suggested EAE mice exhibit hippocampal impairment cognitive deficits. However, underlying mechanisms still unclear. The NLRP3 inflammasome key contributor to...
Diabetic nephropathy is a diabetic complication caused by chronic inflammation. As the primary polyphenol in pomegranate, punicalagin believed to have significant anti-inflammatory properties. In this study, we established mice model for diabetes induced high-fat diet (HFD)/ streptozotocin (STZ) verify protective effect of vivo. The results show that blood urea nitrogen (BUN), serum creatinine (CREA), and urine albumin ratio (UACR) were significantly decreased after intervention, symptoms...
Extracellular vesicles (EVs) hold great potential in both disease treatment and drug delivery. However, accurate release from EVs, as well the spontaneous effect cooperation of EVs drugs at target tissues, is still challenging. Here, an engineered self-activatable photo-EV for synergistic trimodal anticancer therapy reported. M1 macrophage-derived (M1 EVs) are simultaneously loaded with bis[2,4,5-trichloro-6-(pentyloxycarbonyl) phenyl] oxalate (CPPO), chlorin e6 (Ce6), prodrug aldoxorubicin...
Abstract Pure organic room-temperature phosphorescent (RTP) materials have been suggested to be promising bioimaging due their good biocompatibility and long emission lifetime. Herein, we report a class of RTP materials. These are developed through the simple introduction an aromatic carbonyl tetraphenylpyrrole molecule also exhibit aggregation-induced (AIE) properties. molecules show non-emission in solution purely aggregated state, which desirable properties for biological imaging. Highly...
Strong electron correlation and spin-orbit coupling (SOC) can have a profound influence on the electronic properties of materials. We examine their combined 2-dimensional system at atomic interface between magic-angle twisted bilayer graphene tungsten diselenide crystal. within moiré flatband stabilizes correlated insulating states both quarter half filling, SOC transforms these Mott-like insulators into ferromagnets, evidenced by robust anomalous Hall effect with hysteretic switching...
Organic near-infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scales and background noise elimination. However, developing RTP for deep tissue imaging still faces challenges since the small band gap may increase non-radiative decay, resulting weak emission short lifetime. In this study, fused-ring pyrrole-based structures were employed as guest molecules construction of long wavelength emissive materials....
An aggregation-enhanced emission active luminogen named as sodium 4,4'4″-(3,4-diphenyl-1H-pyrrole-1,2,5-triyl)tribenzoate (DP-TPPNa) with propeller construction was synthesized and developed a "turn on" fluorescent probe for in situ quantitation of albumin blood serum. The DP-TPPNa fluorescence intensity linearly correlated the concentration two serum albumins, bovine (BSA) human (HSA), pure PBS buffer ranges 2.18-70 1.68-100 μg/mL, respectively. detection limits were low 2.18 μg/mL BSA 1.68...
Open AccessCCS ChemistryCOMMUNICATION5 Aug 2022Red-Emissive Organic Room-Temperature Phosphorescence Material for Time-Resolved Luminescence Bioimaging Wenbo Dai†, Yahui Zhang†, Xinghui Wu, Shuai Guo, Jieran Ma, Jianbing Shi, Bin Tong, Zhengxu Cai, Haiyan Xie and Yuping Dong Dai† Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials Green Applications, School Science Engineering, Institute Technology, 100081 †W. Dai Y. Zhang contributed equally to this work.Google...
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome considered an important regulator of immunity and inflammation, both which play critical role MS. However, underlying mechanism activation not fully understood. Here we identified that TRPV1 (transient receptor potential vanilloid type 1) channel microglia, as Ca2+ influx-regulating channel, played activation. Deletion or pharmacological blockade inhibited...
ABC-stacked trilayer graphene/hBN moir\'e superlattice (TLG/hBN) has emerged as a playground for correlated electron physics. We report spectroscopy measurements of dual-gated TLG/hBN using Fourier transformed infrared photocurrent spectroscopy. observed strong optical transition between mini-bands that narrows continuously bandgap is opened by gating, indicating reduction the single particle bandwidth. At half-filling valence flat band, broad absorption peak emerges at ~18 meV, direct...
Abstract Osmotic energy represents a promising resource because it is sustainable and environmentally benign. Subnanoscale channels are considered as competitive platform for generating this blue due to their highly selective ultrafast ion transport. However, fabricating functional subnanochannels capable of high output remains challenging. Here, heterogeneous subnanochannel membrane formed by coating functionalized self‐assembled metal−organic framework (MOF) monolayer (SAMM) film on porous...
Abstract Boroxines are significant structures in the production of covalent organic frameworks, anion receptors, self-healing materials, and others. However, their utilization aqueous media is a formidable task due to hydrolytic instability. Here we report water-stable boroxine structure discovered from 2-hydroxyphenylboronic acid. We find that, under ambient environments, acid undergoes spontaneous dehydration form dimer with dynamic bonds aggregation-induced enhanced emission activity....
Aberrant protein phosphorylation and glycosylation are closely associated with a number of diseases. In particular, an interplay between regulates the hyperphosphorylation tau, which is regarded as one pathologic features Alzheimer's disease (AD). However, simultaneous characterization these two types post-translational modifications (PTMs) in complex biological samples challenging. TiO2 immobilized ion affinity chromatography (IMAC)-based enrichment method suffers from low selectivity...